ANTIBODIES BINDING TO VISTA AT ACIDIC PH
The present application relates to antibodies specifically binding to the V-domain immunoglobulin-containing suppressor of T-cell activation (VISTA) at acidic pH and their use in cancer treatment. In some embodiments, the antibodies bind specifically to human VISTA at acidic pH, but do not significa...
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| creator | CRITTON, DAVID A DENG, XIAODI RAKESTRAW, GINGER SU, LIN HUI DEYANOVA, EKATERINA G RANKIN, ANDREW RAJPAL, ARVIND PINCKNEY, JASON R KORMAN, ALAN J BORGES, LUIS HUANG, RICHARD Y JOHNSTON, ROBERT J CHEN, GUODONG SHEPPARD, PAUL O BAHJAT, KEITH SADOON |
| description | The present application relates to antibodies specifically binding to the V-domain immunoglobulin-containing suppressor of T-cell activation (VISTA) at acidic pH and their use in cancer treatment. In some embodiments, the antibodies bind specifically to human VISTA at acidic pH, but do not significantly bind to human VISTA at neutral or physiological pH.
L'invention concerne des anticorps qui se lient de manière spécifique au suppresseur de type immunoglobuline à domaine V de l'activation des lymphocytes T (VISTA) à un pH acide, et leur utilisation dans le traitement du cancer. Dans certains modes de réalisation, les anticorps se lient de manière spécifique au VISTA humain à un pH acide, mais ne se lient pas de façon significative au VISTA humain à un pH neutre ou physiologique. |
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L'invention concerne des anticorps qui se lient de manière spécifique au suppresseur de type immunoglobuline à domaine V de l'activation des lymphocytes T (VISTA) à un pH acide, et leur utilisation dans le traitement du cancer. Dans certains modes de réalisation, les anticorps se lient de manière spécifique au VISTA humain à un pH acide, mais ne se lient pas de façon significative au VISTA humain à un pH neutre ou physiologique.</description><language>eng ; fre</language><subject>CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2019</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190926&DB=EPODOC&CC=CA&NR=3092589A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190926&DB=EPODOC&CC=CA&NR=3092589A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>CRITTON, DAVID A</creatorcontrib><creatorcontrib>DENG, XIAODI</creatorcontrib><creatorcontrib>RAKESTRAW, GINGER</creatorcontrib><creatorcontrib>SU, LIN HUI</creatorcontrib><creatorcontrib>DEYANOVA, EKATERINA G</creatorcontrib><creatorcontrib>RANKIN, ANDREW</creatorcontrib><creatorcontrib>RAJPAL, ARVIND</creatorcontrib><creatorcontrib>PINCKNEY, JASON R</creatorcontrib><creatorcontrib>KORMAN, ALAN J</creatorcontrib><creatorcontrib>BORGES, LUIS</creatorcontrib><creatorcontrib>HUANG, RICHARD Y</creatorcontrib><creatorcontrib>JOHNSTON, ROBERT J</creatorcontrib><creatorcontrib>CHEN, GUODONG</creatorcontrib><creatorcontrib>SHEPPARD, PAUL O</creatorcontrib><creatorcontrib>BAHJAT, KEITH SADOON</creatorcontrib><title>ANTIBODIES BINDING TO VISTA AT ACIDIC PH</title><description>The present application relates to antibodies specifically binding to the V-domain immunoglobulin-containing suppressor of T-cell activation (VISTA) at acidic pH and their use in cancer treatment. In some embodiments, the antibodies bind specifically to human VISTA at acidic pH, but do not significantly bind to human VISTA at neutral or physiological pH.
L'invention concerne des anticorps qui se lient de manière spécifique au suppresseur de type immunoglobuline à domaine V de l'activation des lymphocytes T (VISTA) à un pH acide, et leur utilisation dans le traitement du cancer. Dans certains modes de réalisation, les anticorps se lient de manière spécifique au VISTA humain à un pH acide, mais ne se lient pas de façon significative au VISTA humain à un pH neutre ou physiologique.</description><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2019</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNBw9AvxdPJ38XQNVnDy9HPx9HNXCPFXCPMMDnFUcAxRcHT2dPF0Vgjw4GFgTUvMKU7lhdLcDApuriHOHrqpBfnxqcUFicmpeakl8c6OxgaWRqYWlo6GxkQoAQCWaSMu</recordid><startdate>20190926</startdate><enddate>20190926</enddate><creator>CRITTON, DAVID A</creator><creator>DENG, XIAODI</creator><creator>RAKESTRAW, GINGER</creator><creator>SU, LIN HUI</creator><creator>DEYANOVA, EKATERINA G</creator><creator>RANKIN, ANDREW</creator><creator>RAJPAL, ARVIND</creator><creator>PINCKNEY, JASON R</creator><creator>KORMAN, ALAN J</creator><creator>BORGES, LUIS</creator><creator>HUANG, RICHARD Y</creator><creator>JOHNSTON, ROBERT J</creator><creator>CHEN, GUODONG</creator><creator>SHEPPARD, PAUL O</creator><creator>BAHJAT, KEITH SADOON</creator><scope>EVB</scope></search><sort><creationdate>20190926</creationdate><title>ANTIBODIES BINDING TO VISTA AT ACIDIC PH</title><author>CRITTON, DAVID A ; DENG, XIAODI ; RAKESTRAW, GINGER ; SU, LIN HUI ; DEYANOVA, EKATERINA G ; RANKIN, ANDREW ; RAJPAL, ARVIND ; PINCKNEY, JASON R ; KORMAN, ALAN J ; BORGES, LUIS ; HUANG, RICHARD Y ; JOHNSTON, ROBERT J ; CHEN, GUODONG ; SHEPPARD, PAUL O ; BAHJAT, KEITH SADOON</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CA3092589A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2019</creationdate><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>CRITTON, DAVID A</creatorcontrib><creatorcontrib>DENG, XIAODI</creatorcontrib><creatorcontrib>RAKESTRAW, GINGER</creatorcontrib><creatorcontrib>SU, LIN HUI</creatorcontrib><creatorcontrib>DEYANOVA, EKATERINA G</creatorcontrib><creatorcontrib>RANKIN, ANDREW</creatorcontrib><creatorcontrib>RAJPAL, ARVIND</creatorcontrib><creatorcontrib>PINCKNEY, JASON R</creatorcontrib><creatorcontrib>KORMAN, ALAN J</creatorcontrib><creatorcontrib>BORGES, LUIS</creatorcontrib><creatorcontrib>HUANG, RICHARD Y</creatorcontrib><creatorcontrib>JOHNSTON, ROBERT J</creatorcontrib><creatorcontrib>CHEN, GUODONG</creatorcontrib><creatorcontrib>SHEPPARD, PAUL O</creatorcontrib><creatorcontrib>BAHJAT, KEITH SADOON</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>CRITTON, DAVID A</au><au>DENG, XIAODI</au><au>RAKESTRAW, GINGER</au><au>SU, LIN HUI</au><au>DEYANOVA, EKATERINA G</au><au>RANKIN, ANDREW</au><au>RAJPAL, ARVIND</au><au>PINCKNEY, JASON R</au><au>KORMAN, ALAN J</au><au>BORGES, LUIS</au><au>HUANG, RICHARD Y</au><au>JOHNSTON, ROBERT J</au><au>CHEN, GUODONG</au><au>SHEPPARD, PAUL O</au><au>BAHJAT, KEITH SADOON</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>ANTIBODIES BINDING TO VISTA AT ACIDIC PH</title><date>2019-09-26</date><risdate>2019</risdate><abstract>The present application relates to antibodies specifically binding to the V-domain immunoglobulin-containing suppressor of T-cell activation (VISTA) at acidic pH and their use in cancer treatment. In some embodiments, the antibodies bind specifically to human VISTA at acidic pH, but do not significantly bind to human VISTA at neutral or physiological pH.
L'invention concerne des anticorps qui se lient de manière spécifique au suppresseur de type immunoglobuline à domaine V de l'activation des lymphocytes T (VISTA) à un pH acide, et leur utilisation dans le traitement du cancer. Dans certains modes de réalisation, les anticorps se lient de manière spécifique au VISTA humain à un pH acide, mais ne se lient pas de façon significative au VISTA humain à un pH neutre ou physiologique.</abstract><oa>free_for_read</oa></addata></record> |
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| title | ANTIBODIES BINDING TO VISTA AT ACIDIC PH |
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