PREPARATION FOR MAGNETIC RESONANCE DIAGNOSTICS FOR ONCOLOGICAL DISEASES, COMPRISING DEUTERATED 2-AMINO-2-METHYLPROPIONIC ACID AND/OR 2-(N-METHYLAMINO)-2-METHYLPROPIONIC ACID, AND DIAGNOSTIC METHOD USING SAID PREPARATION
The invention relates to medicine, particularly to agents for magnetic resonance diagnostics for oncological diseases. Developed for this purpose are a diagnostic preparation and a diagnostic method based on using said diagnostic preparation, in which a deuterated derivative of 2-amino-2-methylpropi...
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| creator | IVASHKIN, PAVEL EVGENIEVICH POLSHAKOV, VLADIMIR IVANOVICH KISELEVSKY, MIKHAIL VALENTINOVICH LESIV, ALEKSEI VALERIEVICH GULYAEV, MIKHAIL VLADIMIROVICH KOSENKOV, ALEKSEI VIKTOROVICH DOROFEEVA, EVGENIYA OLEGOVNA |
| description | The invention relates to medicine, particularly to agents for magnetic resonance diagnostics for oncological diseases. Developed for this purpose are a diagnostic preparation and a diagnostic method based on using said diagnostic preparation, in which a deuterated derivative of 2-amino-2-methylpropionic acid or 2-(N-methylamino)-2-methylpropionic acid and/or a pharmaceutically acceptable salt thereof, or a mixture of at least two deuterated derivatives of 2-amino-2-methylpropionic acid and/or 2-(N-methylamino)-2-methylpropionic acid and/or the pharmaceutically acceptable salt thereof is used as said preparation. The method according to the invention includes conducting magnetic resonance imaging and/or magnetic resonance spectroscopy on deuterium nuclei at a time after administration of the diagnostic preparation sufficient for the diagnostic preparation to accumulate in the tumor tissue of a subject in order to produce a magnetic resonance image and/or a magnetic resonance spectrum accordingly. The proposed method enables a highly informed diagnosis of oncological diseases.
L'invention concerne la médecine et notamment des produits de diagnostic par résonance magnétique de maladies oncologiques. A cet effet, on a mis au point un produit de diagnostic et une méthode diagnostique utilisant ce produit en qualité duquel on utilise un dérivé deutéré d'acide 2-amino-2-méthylpropionique deutéré ou d'acide 2-(N-méthylamino)-2-méthylpropionique et/ou son sel pharmaceutiquement acceptable, ou un mélange d'au moins deux dérivés d'acide 2-amino-2-méthylpropionique deutéré ou d'acide 2-(N-méthylamino)-2-méthylpropionique et/ou de son sel pharmaceutiquement acceptable. La méthode de l'invention comprend la réalisation d'une imagerie par résonance magnétique et/ou d'une spectroscopie par résonance magnétique sur les noyaux de deutérium après l'injection de la préparation diagnostique suivant un temps suffisant pour l'accumulation de la préparation diagnostique dans le tissu tumoral du sujet pour obtenir une image et/ou un spectre RM, respectivement. La méthode de l'invention permet d'effectuer le diagnostic de maladies oncologiques avec un degré élevé de fourniture d'informations. |
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L'invention concerne la médecine et notamment des produits de diagnostic par résonance magnétique de maladies oncologiques. A cet effet, on a mis au point un produit de diagnostic et une méthode diagnostique utilisant ce produit en qualité duquel on utilise un dérivé deutéré d'acide 2-amino-2-méthylpropionique deutéré ou d'acide 2-(N-méthylamino)-2-méthylpropionique et/ou son sel pharmaceutiquement acceptable, ou un mélange d'au moins deux dérivés d'acide 2-amino-2-méthylpropionique deutéré ou d'acide 2-(N-méthylamino)-2-méthylpropionique et/ou de son sel pharmaceutiquement acceptable. La méthode de l'invention comprend la réalisation d'une imagerie par résonance magnétique et/ou d'une spectroscopie par résonance magnétique sur les noyaux de deutérium après l'injection de la préparation diagnostique suivant un temps suffisant pour l'accumulation de la préparation diagnostique dans le tissu tumoral du sujet pour obtenir une image et/ou un spectre RM, respectivement. La méthode de l'invention permet d'effectuer le diagnostic de maladies oncologiques avec un degré élevé de fourniture d'informations.</description><language>eng ; fre</language><subject>DIAGNOSIS ; HUMAN NECESSITIES ; HYGIENE ; IDENTIFICATION ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SURGERY</subject><creationdate>2019</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190531&DB=EPODOC&CC=CA&NR=3083111A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,778,883,25547,76298</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190531&DB=EPODOC&CC=CA&NR=3083111A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>IVASHKIN, PAVEL EVGENIEVICH</creatorcontrib><creatorcontrib>POLSHAKOV, VLADIMIR IVANOVICH</creatorcontrib><creatorcontrib>KISELEVSKY, MIKHAIL VALENTINOVICH</creatorcontrib><creatorcontrib>LESIV, ALEKSEI VALERIEVICH</creatorcontrib><creatorcontrib>GULYAEV, MIKHAIL VLADIMIROVICH</creatorcontrib><creatorcontrib>KOSENKOV, ALEKSEI VIKTOROVICH</creatorcontrib><creatorcontrib>DOROFEEVA, EVGENIYA OLEGOVNA</creatorcontrib><title>PREPARATION FOR MAGNETIC RESONANCE DIAGNOSTICS FOR ONCOLOGICAL DISEASES, COMPRISING DEUTERATED 2-AMINO-2-METHYLPROPIONIC ACID AND/OR 2-(N-METHYLAMINO)-2-METHYLPROPIONIC ACID, AND DIAGNOSTIC METHOD USING SAID PREPARATION</title><description>The invention relates to medicine, particularly to agents for magnetic resonance diagnostics for oncological diseases. Developed for this purpose are a diagnostic preparation and a diagnostic method based on using said diagnostic preparation, in which a deuterated derivative of 2-amino-2-methylpropionic acid or 2-(N-methylamino)-2-methylpropionic acid and/or a pharmaceutically acceptable salt thereof, or a mixture of at least two deuterated derivatives of 2-amino-2-methylpropionic acid and/or 2-(N-methylamino)-2-methylpropionic acid and/or the pharmaceutically acceptable salt thereof is used as said preparation. The method according to the invention includes conducting magnetic resonance imaging and/or magnetic resonance spectroscopy on deuterium nuclei at a time after administration of the diagnostic preparation sufficient for the diagnostic preparation to accumulate in the tumor tissue of a subject in order to produce a magnetic resonance image and/or a magnetic resonance spectrum accordingly. The proposed method enables a highly informed diagnosis of oncological diseases.
L'invention concerne la médecine et notamment des produits de diagnostic par résonance magnétique de maladies oncologiques. A cet effet, on a mis au point un produit de diagnostic et une méthode diagnostique utilisant ce produit en qualité duquel on utilise un dérivé deutéré d'acide 2-amino-2-méthylpropionique deutéré ou d'acide 2-(N-méthylamino)-2-méthylpropionique et/ou son sel pharmaceutiquement acceptable, ou un mélange d'au moins deux dérivés d'acide 2-amino-2-méthylpropionique deutéré ou d'acide 2-(N-méthylamino)-2-méthylpropionique et/ou de son sel pharmaceutiquement acceptable. La méthode de l'invention comprend la réalisation d'une imagerie par résonance magnétique et/ou d'une spectroscopie par résonance magnétique sur les noyaux de deutérium après l'injection de la préparation diagnostique suivant un temps suffisant pour l'accumulation de la préparation diagnostique dans le tissu tumoral du sujet pour obtenir une image et/ou un spectre RM, respectivement. La méthode de l'invention permet d'effectuer le diagnostic de maladies oncologiques avec un degré élevé de fourniture d'informations.</description><subject>DIAGNOSIS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>IDENTIFICATION</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SURGERY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2019</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNj7EKAjEMhm9xEPUdMipY9O4W19DGs3CXlLYOTiJSJ1FB39aXsR4OLoJT4M-XL8mweDpPDj1GKwxr8dBhwxStBk9BGFkTGJszCTkMPSKspZXGamxzLxAGCnPQ0jlvg-UGDG0jZScZqBR2lkVVqqO42bXOi8ursh-1NYBsFtlYqSl_gB6f_eDn74Gve-ANiYFtvzZgNn79My4Gp8P5niafOipgTVFvVLpd9-l-OxzTJT32Guvlqi7LEsv6D-QFaOlUIw</recordid><startdate>20190531</startdate><enddate>20190531</enddate><creator>IVASHKIN, PAVEL EVGENIEVICH</creator><creator>POLSHAKOV, VLADIMIR IVANOVICH</creator><creator>KISELEVSKY, MIKHAIL VALENTINOVICH</creator><creator>LESIV, ALEKSEI VALERIEVICH</creator><creator>GULYAEV, MIKHAIL VLADIMIROVICH</creator><creator>KOSENKOV, ALEKSEI VIKTOROVICH</creator><creator>DOROFEEVA, EVGENIYA OLEGOVNA</creator><scope>EVB</scope></search><sort><creationdate>20190531</creationdate><title>PREPARATION FOR MAGNETIC RESONANCE DIAGNOSTICS FOR ONCOLOGICAL DISEASES, COMPRISING DEUTERATED 2-AMINO-2-METHYLPROPIONIC ACID AND/OR 2-(N-METHYLAMINO)-2-METHYLPROPIONIC ACID, AND DIAGNOSTIC METHOD USING SAID PREPARATION</title><author>IVASHKIN, PAVEL EVGENIEVICH ; POLSHAKOV, VLADIMIR IVANOVICH ; KISELEVSKY, MIKHAIL VALENTINOVICH ; LESIV, ALEKSEI VALERIEVICH ; GULYAEV, MIKHAIL VLADIMIROVICH ; KOSENKOV, ALEKSEI VIKTOROVICH ; DOROFEEVA, EVGENIYA OLEGOVNA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CA3083111A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2019</creationdate><topic>DIAGNOSIS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>IDENTIFICATION</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SURGERY</topic><toplevel>online_resources</toplevel><creatorcontrib>IVASHKIN, PAVEL EVGENIEVICH</creatorcontrib><creatorcontrib>POLSHAKOV, VLADIMIR IVANOVICH</creatorcontrib><creatorcontrib>KISELEVSKY, MIKHAIL VALENTINOVICH</creatorcontrib><creatorcontrib>LESIV, ALEKSEI VALERIEVICH</creatorcontrib><creatorcontrib>GULYAEV, MIKHAIL VLADIMIROVICH</creatorcontrib><creatorcontrib>KOSENKOV, ALEKSEI VIKTOROVICH</creatorcontrib><creatorcontrib>DOROFEEVA, EVGENIYA OLEGOVNA</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>IVASHKIN, PAVEL EVGENIEVICH</au><au>POLSHAKOV, VLADIMIR IVANOVICH</au><au>KISELEVSKY, MIKHAIL VALENTINOVICH</au><au>LESIV, ALEKSEI VALERIEVICH</au><au>GULYAEV, MIKHAIL VLADIMIROVICH</au><au>KOSENKOV, ALEKSEI VIKTOROVICH</au><au>DOROFEEVA, EVGENIYA OLEGOVNA</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PREPARATION FOR MAGNETIC RESONANCE DIAGNOSTICS FOR ONCOLOGICAL DISEASES, COMPRISING DEUTERATED 2-AMINO-2-METHYLPROPIONIC ACID AND/OR 2-(N-METHYLAMINO)-2-METHYLPROPIONIC ACID, AND DIAGNOSTIC METHOD USING SAID PREPARATION</title><date>2019-05-31</date><risdate>2019</risdate><abstract>The invention relates to medicine, particularly to agents for magnetic resonance diagnostics for oncological diseases. Developed for this purpose are a diagnostic preparation and a diagnostic method based on using said diagnostic preparation, in which a deuterated derivative of 2-amino-2-methylpropionic acid or 2-(N-methylamino)-2-methylpropionic acid and/or a pharmaceutically acceptable salt thereof, or a mixture of at least two deuterated derivatives of 2-amino-2-methylpropionic acid and/or 2-(N-methylamino)-2-methylpropionic acid and/or the pharmaceutically acceptable salt thereof is used as said preparation. The method according to the invention includes conducting magnetic resonance imaging and/or magnetic resonance spectroscopy on deuterium nuclei at a time after administration of the diagnostic preparation sufficient for the diagnostic preparation to accumulate in the tumor tissue of a subject in order to produce a magnetic resonance image and/or a magnetic resonance spectrum accordingly. The proposed method enables a highly informed diagnosis of oncological diseases.
L'invention concerne la médecine et notamment des produits de diagnostic par résonance magnétique de maladies oncologiques. A cet effet, on a mis au point un produit de diagnostic et une méthode diagnostique utilisant ce produit en qualité duquel on utilise un dérivé deutéré d'acide 2-amino-2-méthylpropionique deutéré ou d'acide 2-(N-méthylamino)-2-méthylpropionique et/ou son sel pharmaceutiquement acceptable, ou un mélange d'au moins deux dérivés d'acide 2-amino-2-méthylpropionique deutéré ou d'acide 2-(N-méthylamino)-2-méthylpropionique et/ou de son sel pharmaceutiquement acceptable. La méthode de l'invention comprend la réalisation d'une imagerie par résonance magnétique et/ou d'une spectroscopie par résonance magnétique sur les noyaux de deutérium après l'injection de la préparation diagnostique suivant un temps suffisant pour l'accumulation de la préparation diagnostique dans le tissu tumoral du sujet pour obtenir une image et/ou un spectre RM, respectivement. La méthode de l'invention permet d'effectuer le diagnostic de maladies oncologiques avec un degré élevé de fourniture d'informations.</abstract><oa>free_for_read</oa></addata></record> |
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| title | PREPARATION FOR MAGNETIC RESONANCE DIAGNOSTICS FOR ONCOLOGICAL DISEASES, COMPRISING DEUTERATED 2-AMINO-2-METHYLPROPIONIC ACID AND/OR 2-(N-METHYLAMINO)-2-METHYLPROPIONIC ACID, AND DIAGNOSTIC METHOD USING SAID PREPARATION |
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