CRYSTALLINE FORM OF LORLATINIB FREE BASE HYDRATE

This invention relates to a crystalline form of (10R)-7-amino-12-fluoro-2,10,16-trimethyl- 15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclo- tetradecine-3-carbonitrile (lorlatinib) free base hydrate (Form 24). This invention also relates to pharmaceutical compos...

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Hauptverfasser:	BOWLES, PAUL, ROSE, PETER ROBERT
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	This invention relates to a crystalline form of (10R)-7-amino-12-fluoro-2,10,16-trimethyl- 15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclo- tetradecine-3-carbonitrile (lorlatinib) free base hydrate (Form 24). This invention also relates to pharmaceutical compositions comprising Form 24, and to methods of using Form 24 and such compositions in the treatment of abnormal cell growth, such as cancer, in a mammal. La présente invention concerne une forme cristalline d'hydrate de base libre de (10R)-7-amino-12-fluoro-2,10,16-triméthyl- 15-oxo-10,15,16,17-tétrahydro-2H-8,4-(métheno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclo- tétradécine-3-carbonitrile (lorlatinib) (forme 24). L'invention concerne également des compositions pharmaceutiques comprenant la forme 24 et des procédés d'utilisation de celle-ci et de telles compositions dans le traitement de la croissance cellulaire anormale, notamment le cancer, chez un mammifère.