N2,N4-DIPHENYLPYRIMIDINE-2,4-DIAMINE DERIVATIVE, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT FOR PREVENTION OR TREATMENT OF CANCER
The present application relates to N2, N4-diphenylpyrimidin-2,4-diamine compounds of Formula 1. The application also includes methods for preparing compounds of Formula 1, pharmaceutical compositions comprising the compounds and to uses thereof, for example, for the prevention or treatment of cancer...
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| creator | KIM, HWAN JEON, BYEONG UK SHIN, INJI PARK, CHAE WON CHAE, CHONG HAK DUGGIRALA, KRISHNA BABU JUNG, MYOUNG EUN CHOI, GILDON CHO, BYOUNG CHUL LEE, KWANGHO CHOE, HYEON JEONG |
| description | The present application relates to N2, N4-diphenylpyrimidin-2,4-diamine compounds of Formula 1. The application also includes methods for preparing compounds of Formula 1, pharmaceutical compositions comprising the compounds and to uses thereof, for example, for the prevention or treatment of cancer such as cancer with EGFR mutations or cancer with FLT3 or a mutation thereof. a (1)
La présente invention concerne un dérivé de N2,N4-diphénylpyrimidine-2,4-diamine, son procédé de préparation, et une composition pharmaceutique le contenant comme principe actif pour la prévention ou le traitement du cancer. Le dérivé présente un effet inhibiteur de l'activité d'EGFR relativement faible sur l'EGFR de type sauvage, une capacité inhibitrice élevée sur la mutation de l'EGFR, et une capacité inhibitrice élevée même sur FLT3 ou sur la mutation FLT3, et peut ainsi être utilisé favorablement dans le traitement du cancer à mutation de l'EGFR ou du cancer à FLT3 ou à mutation FLT3, et le dérivé présente un effet de synergie au moment de son administration combinée, et peut ainsi être favorablement utilisé dans le traitement par administration combinée. |
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La présente invention concerne un dérivé de N2,N4-diphénylpyrimidine-2,4-diamine, son procédé de préparation, et une composition pharmaceutique le contenant comme principe actif pour la prévention ou le traitement du cancer. Le dérivé présente un effet inhibiteur de l'activité d'EGFR relativement faible sur l'EGFR de type sauvage, une capacité inhibitrice élevée sur la mutation de l'EGFR, et une capacité inhibitrice élevée même sur FLT3 ou sur la mutation FLT3, et peut ainsi être utilisé favorablement dans le traitement du cancer à mutation de l'EGFR ou du cancer à FLT3 ou à mutation FLT3, et le dérivé présente un effet de synergie au moment de son administration combinée, et peut ainsi être favorablement utilisé dans le traitement par administration combinée.</description><language>eng ; fre</language><subject>CHEMISTRY ; FOODS OR FOODSTUFFS ; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL ; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT ; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES</subject><creationdate>2021</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20211130&DB=EPODOC&CC=CA&NR=3066083C$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20211130&DB=EPODOC&CC=CA&NR=3066083C$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>KIM, HWAN</creatorcontrib><creatorcontrib>JEON, BYEONG UK</creatorcontrib><creatorcontrib>SHIN, INJI</creatorcontrib><creatorcontrib>PARK, CHAE WON</creatorcontrib><creatorcontrib>CHAE, CHONG HAK</creatorcontrib><creatorcontrib>DUGGIRALA, KRISHNA BABU</creatorcontrib><creatorcontrib>JUNG, MYOUNG EUN</creatorcontrib><creatorcontrib>CHOI, GILDON</creatorcontrib><creatorcontrib>CHO, BYOUNG CHUL</creatorcontrib><creatorcontrib>LEE, KWANGHO</creatorcontrib><creatorcontrib>CHOE, HYEON JEONG</creatorcontrib><title>N2,N4-DIPHENYLPYRIMIDINE-2,4-DIAMINE DERIVATIVE, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT FOR PREVENTION OR TREATMENT OF CANCER</title><description>The present application relates to N2, N4-diphenylpyrimidin-2,4-diamine compounds of Formula 1. The application also includes methods for preparing compounds of Formula 1, pharmaceutical compositions comprising the compounds and to uses thereof, for example, for the prevention or treatment of cancer such as cancer with EGFR mutations or cancer with FLT3 or a mutation thereof. a (1)
La présente invention concerne un dérivé de N2,N4-diphénylpyrimidine-2,4-diamine, son procédé de préparation, et une composition pharmaceutique le contenant comme principe actif pour la prévention ou le traitement du cancer. Le dérivé présente un effet inhibiteur de l'activité d'EGFR relativement faible sur l'EGFR de type sauvage, une capacité inhibitrice élevée sur la mutation de l'EGFR, et une capacité inhibitrice élevée même sur FLT3 ou sur la mutation FLT3, et peut ainsi être utilisé favorablement dans le traitement du cancer à mutation de l'EGFR ou du cancer à FLT3 ou à mutation FLT3, et le dérivé présente un effet de synergie au moment de son administration combinée, et peut ainsi être favorablement utilisé dans le traitement par administration combinée.</description><subject>CHEMISTRY</subject><subject>FOODS OR FOODSTUFFS</subject><subject>FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL</subject><subject>THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT</subject><subject>THEIR TREATMENT, NOT COVERED BY OTHER CLASSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2021</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqFjEtqw0AMhr3pojQ9Q3UAG0JcQrdCI9eCjGaQVUNWIZTpqiSB9Gq5X8fQrLvSp__12Nx00-prFySPrPtd3ptECaLcbdpFxlgZApvM6DJzC5F9TAGGZJCNM5roO0wYq4UaII9oEYk_XAh3QCnmNIlL0srqKHrPA06AtIxClYyDsPp9d668dOrnxuhx8dIAhEpsq-bh6_h9Lc9_96l5Gdhp7MrlfCjXy_GznMrPgbBfb7frt576_xO_3tVJZg</recordid><startdate>20211130</startdate><enddate>20211130</enddate><creator>KIM, HWAN</creator><creator>JEON, BYEONG UK</creator><creator>SHIN, INJI</creator><creator>PARK, CHAE WON</creator><creator>CHAE, CHONG HAK</creator><creator>DUGGIRALA, KRISHNA BABU</creator><creator>JUNG, MYOUNG EUN</creator><creator>CHOI, GILDON</creator><creator>CHO, BYOUNG CHUL</creator><creator>LEE, KWANGHO</creator><creator>CHOE, HYEON JEONG</creator><scope>EVB</scope></search><sort><creationdate>20211130</creationdate><title>N2,N4-DIPHENYLPYRIMIDINE-2,4-DIAMINE DERIVATIVE, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT FOR PREVENTION OR TREATMENT OF CANCER</title><author>KIM, HWAN ; JEON, BYEONG UK ; SHIN, INJI ; PARK, CHAE WON ; CHAE, CHONG HAK ; DUGGIRALA, KRISHNA BABU ; JUNG, MYOUNG EUN ; CHOI, GILDON ; CHO, BYOUNG CHUL ; LEE, KWANGHO ; CHOE, HYEON JEONG</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CA3066083C3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2021</creationdate><topic>CHEMISTRY</topic><topic>FOODS OR FOODSTUFFS</topic><topic>FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL</topic><topic>THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT</topic><topic>THEIR TREATMENT, NOT COVERED BY OTHER CLASSES</topic><toplevel>online_resources</toplevel><creatorcontrib>KIM, HWAN</creatorcontrib><creatorcontrib>JEON, BYEONG UK</creatorcontrib><creatorcontrib>SHIN, INJI</creatorcontrib><creatorcontrib>PARK, CHAE WON</creatorcontrib><creatorcontrib>CHAE, CHONG HAK</creatorcontrib><creatorcontrib>DUGGIRALA, KRISHNA BABU</creatorcontrib><creatorcontrib>JUNG, MYOUNG EUN</creatorcontrib><creatorcontrib>CHOI, GILDON</creatorcontrib><creatorcontrib>CHO, BYOUNG CHUL</creatorcontrib><creatorcontrib>LEE, KWANGHO</creatorcontrib><creatorcontrib>CHOE, HYEON JEONG</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>KIM, HWAN</au><au>JEON, BYEONG UK</au><au>SHIN, INJI</au><au>PARK, CHAE WON</au><au>CHAE, CHONG HAK</au><au>DUGGIRALA, KRISHNA BABU</au><au>JUNG, MYOUNG EUN</au><au>CHOI, GILDON</au><au>CHO, BYOUNG CHUL</au><au>LEE, KWANGHO</au><au>CHOE, HYEON JEONG</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>N2,N4-DIPHENYLPYRIMIDINE-2,4-DIAMINE DERIVATIVE, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT FOR PREVENTION OR TREATMENT OF CANCER</title><date>2021-11-30</date><risdate>2021</risdate><abstract>The present application relates to N2, N4-diphenylpyrimidin-2,4-diamine compounds of Formula 1. The application also includes methods for preparing compounds of Formula 1, pharmaceutical compositions comprising the compounds and to uses thereof, for example, for the prevention or treatment of cancer such as cancer with EGFR mutations or cancer with FLT3 or a mutation thereof. a (1)
La présente invention concerne un dérivé de N2,N4-diphénylpyrimidine-2,4-diamine, son procédé de préparation, et une composition pharmaceutique le contenant comme principe actif pour la prévention ou le traitement du cancer. Le dérivé présente un effet inhibiteur de l'activité d'EGFR relativement faible sur l'EGFR de type sauvage, une capacité inhibitrice élevée sur la mutation de l'EGFR, et une capacité inhibitrice élevée même sur FLT3 ou sur la mutation FLT3, et peut ainsi être utilisé favorablement dans le traitement du cancer à mutation de l'EGFR ou du cancer à FLT3 ou à mutation FLT3, et le dérivé présente un effet de synergie au moment de son administration combinée, et peut ainsi être favorablement utilisé dans le traitement par administration combinée.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY FOODS OR FOODSTUFFS FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT THEIR TREATMENT, NOT COVERED BY OTHER CLASSES |
| title | N2,N4-DIPHENYLPYRIMIDINE-2,4-DIAMINE DERIVATIVE, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT FOR PREVENTION OR TREATMENT OF CANCER |
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