FLUOROGEN-BINDING RNA APTAMERS
RNA aptamers are disclosed with distinct fluorescent properties, fluorophore binding affinities, and salt dependence. Also disclosed are corresponding fluorophores, with selected fluorophores evidencing high cellular permeability. The aptamer's high fluorophore affinities, the high brightness o...
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| creator | JENG, SUNNY CHIU YUK ABDOLAHZADEH, AMIR AUTOUR, ALEXIS PANCHAPAKESAN, SHANKER SHYAM SUNDHAR COJOCARU, RAZVAN FERRE D'AMARE, ADRIAN UNRAU, PETER DOLGOSHEINA, ELENA TRACHMAN, ROBERT RYCKELYNCK, MICHAEL |
| description | RNA aptamers are disclosed with distinct fluorescent properties, fluorophore binding affinities, and salt dependence. Also disclosed are corresponding fluorophores, with selected fluorophores evidencing high cellular permeability. The aptamer's high fluorophore affinities, the high brightness of the bound complexes, and their thermal and salt stability, provide distinct aspects of the disclosed aptamers.
L'invention concerne des aptamères d'ARN ayant des propriétés fluorescentes distinctes, des affinités de liaison à un fluorophore et une dépendance au sel. L'invention concerne également des fluorophores correspondants, des fluorophores sélectionnés mettant en évidence une perméabilité cellulaire élevée. Les affinités élevées de l'aptamère à un fluorophore, la luminosité élevée des complexes liés et leur stabilité thermique et saline fournissent des aspects distincts des aptamères de l'invention. |
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L'invention concerne des aptamères d'ARN ayant des propriétés fluorescentes distinctes, des affinités de liaison à un fluorophore et une dépendance au sel. L'invention concerne également des fluorophores correspondants, des fluorophores sélectionnés mettant en évidence une perméabilité cellulaire élevée. Les affinités élevées de l'aptamère à un fluorophore, la luminosité élevée des complexes liés et leur stabilité thermique et saline fournissent des aspects distincts des aptamères de l'invention.</description><language>eng ; fre</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS OR TEST PAPERS THEREFOR ; COMPOSITIONS THEREOF ; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ; CULTURE MEDIA ; ENZYMOLOGY ; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; PROCESSES OF PREPARING SUCH COMPOSITIONS ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2018</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20181101&DB=EPODOC&CC=CA&NR=3060379A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20181101&DB=EPODOC&CC=CA&NR=3060379A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>JENG, SUNNY CHIU YUK</creatorcontrib><creatorcontrib>ABDOLAHZADEH, AMIR</creatorcontrib><creatorcontrib>AUTOUR, ALEXIS</creatorcontrib><creatorcontrib>PANCHAPAKESAN, SHANKER SHYAM SUNDHAR</creatorcontrib><creatorcontrib>COJOCARU, RAZVAN</creatorcontrib><creatorcontrib>FERRE D'AMARE, ADRIAN</creatorcontrib><creatorcontrib>UNRAU, PETER</creatorcontrib><creatorcontrib>DOLGOSHEINA, ELENA</creatorcontrib><creatorcontrib>TRACHMAN, ROBERT</creatorcontrib><creatorcontrib>RYCKELYNCK, MICHAEL</creatorcontrib><title>FLUOROGEN-BINDING RNA APTAMERS</title><description>RNA aptamers are disclosed with distinct fluorescent properties, fluorophore binding affinities, and salt dependence. Also disclosed are corresponding fluorophores, with selected fluorophores evidencing high cellular permeability. The aptamer's high fluorophore affinities, the high brightness of the bound complexes, and their thermal and salt stability, provide distinct aspects of the disclosed aptamers.
L'invention concerne des aptamères d'ARN ayant des propriétés fluorescentes distinctes, des affinités de liaison à un fluorophore et une dépendance au sel. L'invention concerne également des fluorophores correspondants, des fluorophores sélectionnés mettant en évidence une perméabilité cellulaire élevée. Les affinités élevées de l'aptamère à un fluorophore, la luminosité élevée des complexes liés et leur stabilité thermique et saline fournissent des aspects distincts des aptamères de l'invention.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS OR TEST PAPERS THEREFOR</subject><subject>COMPOSITIONS THEREOF</subject><subject>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PROCESSES OF PREPARING SUCH COMPOSITIONS</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2018</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZJBz8wn1D_J3d_XTdfL0c_H0c1cI8nNUcAwIcfR1DQrmYWBNS8wpTuWF0twMCm6uIc4euqkF-fGpxQWJyal5qSXxzo7GBmYGxuaWjobGRCgBAHOkINo</recordid><startdate>20181101</startdate><enddate>20181101</enddate><creator>JENG, SUNNY CHIU YUK</creator><creator>ABDOLAHZADEH, AMIR</creator><creator>AUTOUR, ALEXIS</creator><creator>PANCHAPAKESAN, SHANKER SHYAM SUNDHAR</creator><creator>COJOCARU, RAZVAN</creator><creator>FERRE D'AMARE, ADRIAN</creator><creator>UNRAU, PETER</creator><creator>DOLGOSHEINA, ELENA</creator><creator>TRACHMAN, ROBERT</creator><creator>RYCKELYNCK, MICHAEL</creator><scope>EVB</scope></search><sort><creationdate>20181101</creationdate><title>FLUOROGEN-BINDING RNA APTAMERS</title><author>JENG, SUNNY CHIU YUK ; ABDOLAHZADEH, AMIR ; AUTOUR, ALEXIS ; PANCHAPAKESAN, SHANKER SHYAM SUNDHAR ; COJOCARU, RAZVAN ; FERRE D'AMARE, ADRIAN ; UNRAU, PETER ; DOLGOSHEINA, ELENA ; TRACHMAN, ROBERT ; RYCKELYNCK, MICHAEL</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CA3060379A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2018</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS OR TEST PAPERS THEREFOR</topic><topic>COMPOSITIONS THEREOF</topic><topic>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PROCESSES OF PREPARING SUCH COMPOSITIONS</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>JENG, SUNNY CHIU YUK</creatorcontrib><creatorcontrib>ABDOLAHZADEH, AMIR</creatorcontrib><creatorcontrib>AUTOUR, ALEXIS</creatorcontrib><creatorcontrib>PANCHAPAKESAN, SHANKER SHYAM SUNDHAR</creatorcontrib><creatorcontrib>COJOCARU, RAZVAN</creatorcontrib><creatorcontrib>FERRE D'AMARE, ADRIAN</creatorcontrib><creatorcontrib>UNRAU, PETER</creatorcontrib><creatorcontrib>DOLGOSHEINA, ELENA</creatorcontrib><creatorcontrib>TRACHMAN, ROBERT</creatorcontrib><creatorcontrib>RYCKELYNCK, MICHAEL</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>JENG, SUNNY CHIU YUK</au><au>ABDOLAHZADEH, AMIR</au><au>AUTOUR, ALEXIS</au><au>PANCHAPAKESAN, SHANKER SHYAM SUNDHAR</au><au>COJOCARU, RAZVAN</au><au>FERRE D'AMARE, ADRIAN</au><au>UNRAU, PETER</au><au>DOLGOSHEINA, ELENA</au><au>TRACHMAN, ROBERT</au><au>RYCKELYNCK, MICHAEL</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>FLUOROGEN-BINDING RNA APTAMERS</title><date>2018-11-01</date><risdate>2018</risdate><abstract>RNA aptamers are disclosed with distinct fluorescent properties, fluorophore binding affinities, and salt dependence. Also disclosed are corresponding fluorophores, with selected fluorophores evidencing high cellular permeability. The aptamer's high fluorophore affinities, the high brightness of the bound complexes, and their thermal and salt stability, provide distinct aspects of the disclosed aptamers.
L'invention concerne des aptamères d'ARN ayant des propriétés fluorescentes distinctes, des affinités de liaison à un fluorophore et une dépendance au sel. L'invention concerne également des fluorophores correspondants, des fluorophores sélectionnés mettant en évidence une perméabilité cellulaire élevée. Les affinités élevées de l'aptamère à un fluorophore, la luminosité élevée des complexes liés et leur stabilité thermique et saline fournissent des aspects distincts des aptamères de l'invention.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE |
| title | FLUOROGEN-BINDING RNA APTAMERS |
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