5-(PYRIMIDIN-4-YL)-2-(PYRROLIDIN-1-YL)NICOTINONITRILE COMPOUNDS AS IKKE, TBK1 AND/OR SIK2 KINASES INHIBITORS
The invention provides compounds of formula (I) wherein R is -CH3 or -CH2CH3 and pharmaceutically acceptable salts thereof. The compounds of formula (I) are useful in the treatment of diseases or disorders mediated by IKKE, TBK1 and/or SIK2 mechanisms in a subject, for example cancer and inflammator...
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| creator | STEWART, MARK RICHARD NEWTON, GARY KARL |
| description | The invention provides compounds of formula (I) wherein R is -CH3 or -CH2CH3 and pharmaceutically acceptable salts thereof. The compounds of formula (I) are useful in the treatment of diseases or disorders mediated by IKKE, TBK1 and/or SIK2 mechanisms in a subject, for example cancer and inflammatory and tissue repair disorders. The invention also provides uses of the compounds of formula (I) and compositions containing them. (Formula (I))
L'invention concerne des composés de formule (I) tels que définis dans la description, et des sels pharmaceutiquement acceptables de ceux-ci. Dans la formule, R représente -CH3 ou -CH2CH3. Les composés de formule (I) sont utiles dans le traitement de maladies ou de troubles induits par les mécanismes IKKE, TBK1 et/ou SIK2 chez un sujet, par exemple le cancer et les troubles inflammatoires et de réparation tissulaire. L'invention concerne également des utilisations des composés de formule (I) et des compositions les contenant. (Formule (I)) |
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L'invention concerne des composés de formule (I) tels que définis dans la description, et des sels pharmaceutiquement acceptables de ceux-ci. Dans la formule, R représente -CH3 ou -CH2CH3. Les composés de formule (I) sont utiles dans le traitement de maladies ou de troubles induits par les mécanismes IKKE, TBK1 et/ou SIK2 chez un sujet, par exemple le cancer et les troubles inflammatoires et de réparation tissulaire. L'invention concerne également des utilisations des composés de formule (I) et des compositions les contenant. (Formule (I))</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2018</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20180830&DB=EPODOC&CC=CA&NR=3054343A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,309,782,887,25573,76557</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20180830&DB=EPODOC&CC=CA&NR=3054343A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>STEWART, MARK RICHARD</creatorcontrib><creatorcontrib>NEWTON, GARY KARL</creatorcontrib><title>5-(PYRIMIDIN-4-YL)-2-(PYRROLIDIN-1-YL)NICOTINONITRILE COMPOUNDS AS IKKE, TBK1 AND/OR SIK2 KINASES INHIBITORS</title><description>The invention provides compounds of formula (I) wherein R is -CH3 or -CH2CH3 and pharmaceutically acceptable salts thereof. The compounds of formula (I) are useful in the treatment of diseases or disorders mediated by IKKE, TBK1 and/or SIK2 mechanisms in a subject, for example cancer and inflammatory and tissue repair disorders. The invention also provides uses of the compounds of formula (I) and compositions containing them. (Formula (I))
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L'invention concerne des composés de formule (I) tels que définis dans la description, et des sels pharmaceutiquement acceptables de ceux-ci. Dans la formule, R représente -CH3 ou -CH2CH3. Les composés de formule (I) sont utiles dans le traitement de maladies ou de troubles induits par les mécanismes IKKE, TBK1 et/ou SIK2 chez un sujet, par exemple le cancer et les troubles inflammatoires et de réparation tissulaire. L'invention concerne également des utilisations des composés de formule (I) et des compositions les contenant. (Formule (I))</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | 5-(PYRIMIDIN-4-YL)-2-(PYRROLIDIN-1-YL)NICOTINONITRILE COMPOUNDS AS IKKE, TBK1 AND/OR SIK2 KINASES INHIBITORS |
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