COMPOSITIONS, ARTICLES OF MANUFACTURE AND METHODS RELATED TO DOSING IN CELL THERAPY
Provided herein are methods, compositions and articles of manufacture for use in connection with cell therapy involving the administration of one or more doses of a therapeutic T cell composition. The cells of the T cell composition express recombinant receptors such as chimeric receptors, e.g. chim...
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| creator | GILBERT, MARK WHITMORE, JAMES BOYD CHARTRAND, NATHANIEL BEAUCHESNE, PASCAL YEE, NATHAN TREDE, NIKOLAUS SEBASTIAN COVINGTON, MICHAEL GERARD RAMSBORG, CHRISTOPHER GLEN LAMBERT, NATHANIEL DAVIS-PICKETT, MEL LI, HE SMITH, JEFF GETTO, RICHARD JAMES WEBER, CLINTON POLLOCK, KATHRYN LINDSAY BECKETT, TRAVIS CHRISTIN, BRIAN LARSON, RYAN P ODEGARD, VALERIE SUTHERLAND, CLAIRE WALKER, ANDREW W DAVE, KEDAR HIMANSHU BLACKMAN, SAMUEL CHARLES MALLANEY, MARY KOWSKI, TOM |
| description | Provided herein are methods, compositions and articles of manufacture for use in connection with cell therapy involving the administration of one or more doses of a therapeutic T cell composition. The cells of the T cell composition express recombinant receptors such as chimeric receptors, e.g. chimeric antigen receptors (CARs) or other transgenic receptors such as T cell receptors (TCRs). Features of the provided embodiments, including the numbers of cells or units of cells administered and/or the potency of administered cells, provide various advantages, such as lower risk of toxicity in subjects administered the T cell compositions.
L'invention concerne des méthodes, des compositions et des articles manufacturés destinés à être utilisés dans le cadre d'une thérapie cellulaire impliquant l'administration d'une ou de plusieurs doses d'une composition de lymphocytes T thérapeutique. Les cellules de la composition de lymphocytes T expriment des récepteurs recombinés tels que des récepteurs chimériques, p. ex. des récepteurs antigéniques chimériques (CAR) ou autres récepteurs transgéniques, tels que des récepteurs de lymphocytes T (TCR). Les caractéristiques des modes de réalisation décrits, dont les nombres de cellules ou d'unités de cellules administrés et/ou la puissance des cellules administrées, procurent divers avantages, tels qu'un risque moins élevé de toxicité chez les sujets recevant lesdites compositions de lymphocytes T. |
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L'invention concerne des méthodes, des compositions et des articles manufacturés destinés à être utilisés dans le cadre d'une thérapie cellulaire impliquant l'administration d'une ou de plusieurs doses d'une composition de lymphocytes T thérapeutique. Les cellules de la composition de lymphocytes T expriment des récepteurs recombinés tels que des récepteurs chimériques, p. ex. des récepteurs antigéniques chimériques (CAR) ou autres récepteurs transgéniques, tels que des récepteurs de lymphocytes T (TCR). Les caractéristiques des modes de réalisation décrits, dont les nombres de cellules ou d'unités de cellules administrés et/ou la puissance des cellules administrées, procurent divers avantages, tels qu'un risque moins élevé de toxicité chez les sujets recevant lesdites compositions de lymphocytes T.</description><language>eng ; fre</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2018</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20180830&DB=EPODOC&CC=CA&NR=3053539A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20180830&DB=EPODOC&CC=CA&NR=3053539A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>GILBERT, MARK</creatorcontrib><creatorcontrib>WHITMORE, JAMES BOYD</creatorcontrib><creatorcontrib>CHARTRAND, NATHANIEL</creatorcontrib><creatorcontrib>BEAUCHESNE, PASCAL</creatorcontrib><creatorcontrib>YEE, NATHAN</creatorcontrib><creatorcontrib>TREDE, NIKOLAUS SEBASTIAN</creatorcontrib><creatorcontrib>COVINGTON, MICHAEL GERARD</creatorcontrib><creatorcontrib>RAMSBORG, CHRISTOPHER GLEN</creatorcontrib><creatorcontrib>LAMBERT, NATHANIEL</creatorcontrib><creatorcontrib>DAVIS-PICKETT, MEL</creatorcontrib><creatorcontrib>LI, HE</creatorcontrib><creatorcontrib>SMITH, JEFF</creatorcontrib><creatorcontrib>GETTO, RICHARD JAMES</creatorcontrib><creatorcontrib>WEBER, CLINTON</creatorcontrib><creatorcontrib>POLLOCK, KATHRYN LINDSAY</creatorcontrib><creatorcontrib>BECKETT, TRAVIS</creatorcontrib><creatorcontrib>CHRISTIN, BRIAN</creatorcontrib><creatorcontrib>LARSON, RYAN P</creatorcontrib><creatorcontrib>ODEGARD, VALERIE</creatorcontrib><creatorcontrib>SUTHERLAND, CLAIRE</creatorcontrib><creatorcontrib>WALKER, ANDREW W</creatorcontrib><creatorcontrib>DAVE, KEDAR HIMANSHU</creatorcontrib><creatorcontrib>BLACKMAN, SAMUEL CHARLES</creatorcontrib><creatorcontrib>MALLANEY, MARY</creatorcontrib><creatorcontrib>KOWSKI, TOM</creatorcontrib><title>COMPOSITIONS, ARTICLES OF MANUFACTURE AND METHODS RELATED TO DOSING IN CELL THERAPY</title><description>Provided herein are methods, compositions and articles of manufacture for use in connection with cell therapy involving the administration of one or more doses of a therapeutic T cell composition. The cells of the T cell composition express recombinant receptors such as chimeric receptors, e.g. chimeric antigen receptors (CARs) or other transgenic receptors such as T cell receptors (TCRs). Features of the provided embodiments, including the numbers of cells or units of cells administered and/or the potency of administered cells, provide various advantages, such as lower risk of toxicity in subjects administered the T cell compositions.
L'invention concerne des méthodes, des compositions et des articles manufacturés destinés à être utilisés dans le cadre d'une thérapie cellulaire impliquant l'administration d'une ou de plusieurs doses d'une composition de lymphocytes T thérapeutique. Les cellules de la composition de lymphocytes T expriment des récepteurs recombinés tels que des récepteurs chimériques, p. ex. des récepteurs antigéniques chimériques (CAR) ou autres récepteurs transgéniques, tels que des récepteurs de lymphocytes T (TCR). Les caractéristiques des modes de réalisation décrits, dont les nombres de cellules ou d'unités de cellules administrés et/ou la puissance des cellules administrées, procurent divers avantages, tels qu'un risque moins élevé de toxicité chez les sujets recevant lesdites compositions de lymphocytes T.</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2018</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNyz0KAjEQQOE0FqLeYQ6goIQtLIfJxATysySzhdWySKxEF9b7o4UHsHrN99aqUo59rl58TnUPWMRT4ArZQsQ0WCQZCgMmA5HFZVOhcEBhA5LBfM90AZ-AOAQQxwX761at7tNjabtfNwosC7lDm19jW-bp1p7tPRLqY6c7fcaT_oN8AJiALzU</recordid><startdate>20180830</startdate><enddate>20180830</enddate><creator>GILBERT, MARK</creator><creator>WHITMORE, JAMES BOYD</creator><creator>CHARTRAND, NATHANIEL</creator><creator>BEAUCHESNE, PASCAL</creator><creator>YEE, NATHAN</creator><creator>TREDE, NIKOLAUS SEBASTIAN</creator><creator>COVINGTON, MICHAEL GERARD</creator><creator>RAMSBORG, CHRISTOPHER GLEN</creator><creator>LAMBERT, NATHANIEL</creator><creator>DAVIS-PICKETT, MEL</creator><creator>LI, HE</creator><creator>SMITH, JEFF</creator><creator>GETTO, RICHARD JAMES</creator><creator>WEBER, CLINTON</creator><creator>POLLOCK, KATHRYN LINDSAY</creator><creator>BECKETT, TRAVIS</creator><creator>CHRISTIN, BRIAN</creator><creator>LARSON, RYAN P</creator><creator>ODEGARD, VALERIE</creator><creator>SUTHERLAND, CLAIRE</creator><creator>WALKER, ANDREW W</creator><creator>DAVE, KEDAR HIMANSHU</creator><creator>BLACKMAN, SAMUEL CHARLES</creator><creator>MALLANEY, MARY</creator><creator>KOWSKI, TOM</creator><scope>EVB</scope></search><sort><creationdate>20180830</creationdate><title>COMPOSITIONS, ARTICLES OF MANUFACTURE AND METHODS RELATED TO DOSING IN CELL THERAPY</title><author>GILBERT, MARK ; WHITMORE, JAMES BOYD ; CHARTRAND, NATHANIEL ; BEAUCHESNE, PASCAL ; YEE, NATHAN ; TREDE, NIKOLAUS SEBASTIAN ; COVINGTON, MICHAEL GERARD ; RAMSBORG, CHRISTOPHER GLEN ; LAMBERT, NATHANIEL ; DAVIS-PICKETT, MEL ; LI, HE ; SMITH, JEFF ; GETTO, RICHARD JAMES ; WEBER, CLINTON ; POLLOCK, KATHRYN LINDSAY ; BECKETT, TRAVIS ; CHRISTIN, BRIAN ; LARSON, RYAN P ; ODEGARD, VALERIE ; SUTHERLAND, CLAIRE ; WALKER, ANDREW W ; DAVE, KEDAR HIMANSHU ; BLACKMAN, SAMUEL CHARLES ; MALLANEY, MARY ; KOWSKI, TOM</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CA3053539A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2018</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>GILBERT, MARK</creatorcontrib><creatorcontrib>WHITMORE, JAMES BOYD</creatorcontrib><creatorcontrib>CHARTRAND, NATHANIEL</creatorcontrib><creatorcontrib>BEAUCHESNE, PASCAL</creatorcontrib><creatorcontrib>YEE, NATHAN</creatorcontrib><creatorcontrib>TREDE, NIKOLAUS SEBASTIAN</creatorcontrib><creatorcontrib>COVINGTON, MICHAEL GERARD</creatorcontrib><creatorcontrib>RAMSBORG, CHRISTOPHER GLEN</creatorcontrib><creatorcontrib>LAMBERT, NATHANIEL</creatorcontrib><creatorcontrib>DAVIS-PICKETT, MEL</creatorcontrib><creatorcontrib>LI, HE</creatorcontrib><creatorcontrib>SMITH, JEFF</creatorcontrib><creatorcontrib>GETTO, RICHARD JAMES</creatorcontrib><creatorcontrib>WEBER, CLINTON</creatorcontrib><creatorcontrib>POLLOCK, KATHRYN LINDSAY</creatorcontrib><creatorcontrib>BECKETT, TRAVIS</creatorcontrib><creatorcontrib>CHRISTIN, BRIAN</creatorcontrib><creatorcontrib>LARSON, RYAN P</creatorcontrib><creatorcontrib>ODEGARD, VALERIE</creatorcontrib><creatorcontrib>SUTHERLAND, CLAIRE</creatorcontrib><creatorcontrib>WALKER, ANDREW W</creatorcontrib><creatorcontrib>DAVE, KEDAR HIMANSHU</creatorcontrib><creatorcontrib>BLACKMAN, SAMUEL CHARLES</creatorcontrib><creatorcontrib>MALLANEY, MARY</creatorcontrib><creatorcontrib>KOWSKI, TOM</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>GILBERT, MARK</au><au>WHITMORE, JAMES BOYD</au><au>CHARTRAND, NATHANIEL</au><au>BEAUCHESNE, PASCAL</au><au>YEE, NATHAN</au><au>TREDE, NIKOLAUS SEBASTIAN</au><au>COVINGTON, MICHAEL GERARD</au><au>RAMSBORG, CHRISTOPHER GLEN</au><au>LAMBERT, NATHANIEL</au><au>DAVIS-PICKETT, MEL</au><au>LI, HE</au><au>SMITH, JEFF</au><au>GETTO, RICHARD JAMES</au><au>WEBER, CLINTON</au><au>POLLOCK, KATHRYN LINDSAY</au><au>BECKETT, TRAVIS</au><au>CHRISTIN, BRIAN</au><au>LARSON, RYAN P</au><au>ODEGARD, VALERIE</au><au>SUTHERLAND, CLAIRE</au><au>WALKER, ANDREW W</au><au>DAVE, KEDAR HIMANSHU</au><au>BLACKMAN, SAMUEL CHARLES</au><au>MALLANEY, MARY</au><au>KOWSKI, TOM</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>COMPOSITIONS, ARTICLES OF MANUFACTURE AND METHODS RELATED TO DOSING IN CELL THERAPY</title><date>2018-08-30</date><risdate>2018</risdate><abstract>Provided herein are methods, compositions and articles of manufacture for use in connection with cell therapy involving the administration of one or more doses of a therapeutic T cell composition. The cells of the T cell composition express recombinant receptors such as chimeric receptors, e.g. chimeric antigen receptors (CARs) or other transgenic receptors such as T cell receptors (TCRs). Features of the provided embodiments, including the numbers of cells or units of cells administered and/or the potency of administered cells, provide various advantages, such as lower risk of toxicity in subjects administered the T cell compositions.
L'invention concerne des méthodes, des compositions et des articles manufacturés destinés à être utilisés dans le cadre d'une thérapie cellulaire impliquant l'administration d'une ou de plusieurs doses d'une composition de lymphocytes T thérapeutique. Les cellules de la composition de lymphocytes T expriment des récepteurs recombinés tels que des récepteurs chimériques, p. ex. des récepteurs antigéniques chimériques (CAR) ou autres récepteurs transgéniques, tels que des récepteurs de lymphocytes T (TCR). Les caractéristiques des modes de réalisation décrits, dont les nombres de cellules ou d'unités de cellules administrés et/ou la puissance des cellules administrées, procurent divers avantages, tels qu'un risque moins élevé de toxicité chez les sujets recevant lesdites compositions de lymphocytes T.</abstract><oa>free_for_read</oa></addata></record> |
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| title | COMPOSITIONS, ARTICLES OF MANUFACTURE AND METHODS RELATED TO DOSING IN CELL THERAPY |
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