ADENOVIRUS ARMED WITH BISPECIFIC T CELL ACTIVATOR
A modified adenovirus, in particular Enadenotucirev (EnAd), armed with a bispecific T cell engager (BiTE) comprising at least two binding domains, wherein at least one of the domains is specific for a surface antigen on a T-cell of interest. Also provided are a composition, such as a pharmaceutical...
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| creator | FISHER, KERRY DAVID FREEDMAN, JOSHUA DAVID CHAMPION, BRIAN ROBERT BROMLEY, ALICE CLAIRE NOEL SEYMOUR, LEONARD WILLIAM |
| description | A modified adenovirus, in particular Enadenotucirev (EnAd), armed with a bispecific T cell engager (BiTE) comprising at least two binding domains, wherein at least one of the domains is specific for a surface antigen on a T-cell of interest. Also provided are a composition, such as a pharmaceutical formulation comprising the virus, use of the virus and virus formulations for treatment, such as in the treatment of cancer. The disclosure also extends to processes for preparing the virus.
L'invention concerne un adénovirus modifié, en particulier l'énadénotucirev (EnAd), équipé d'un activateur de lymphocytes T bispécifique (BiTE) comprenant au moins deux domaines de liaison, au moins l'un des domaines étant spécifique pour un antigène de surface présent sur un lymphocyte T d'intérêt. L'invention concerne également une composition, telle qu'une formulation pharmaceutique comprenant le virus, l'utilisation du virus et des formulations de virus à but thérapeutique, par exemple pour le traitement du cancer. L'invention concerne également des procédés de préparation du virus. |
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L'invention concerne un adénovirus modifié, en particulier l'énadénotucirev (EnAd), équipé d'un activateur de lymphocytes T bispécifique (BiTE) comprenant au moins deux domaines de liaison, au moins l'un des domaines étant spécifique pour un antigène de surface présent sur un lymphocyte T d'intérêt. L'invention concerne également une composition, telle qu'une formulation pharmaceutique comprenant le virus, l'utilisation du virus et des formulations de virus à but thérapeutique, par exemple pour le traitement du cancer. L'invention concerne également des procédés de préparation du virus.</description><language>eng ; fre</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2018</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20180308&DB=EPODOC&CC=CA&NR=3034517A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20180308&DB=EPODOC&CC=CA&NR=3034517A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>FISHER, KERRY DAVID</creatorcontrib><creatorcontrib>FREEDMAN, JOSHUA DAVID</creatorcontrib><creatorcontrib>CHAMPION, BRIAN ROBERT</creatorcontrib><creatorcontrib>BROMLEY, ALICE CLAIRE NOEL</creatorcontrib><creatorcontrib>SEYMOUR, LEONARD WILLIAM</creatorcontrib><title>ADENOVIRUS ARMED WITH BISPECIFIC T CELL ACTIVATOR</title><description>A modified adenovirus, in particular Enadenotucirev (EnAd), armed with a bispecific T cell engager (BiTE) comprising at least two binding domains, wherein at least one of the domains is specific for a surface antigen on a T-cell of interest. Also provided are a composition, such as a pharmaceutical formulation comprising the virus, use of the virus and virus formulations for treatment, such as in the treatment of cancer. The disclosure also extends to processes for preparing the virus.
L'invention concerne un adénovirus modifié, en particulier l'énadénotucirev (EnAd), équipé d'un activateur de lymphocytes T bispécifique (BiTE) comprenant au moins deux domaines de liaison, au moins l'un des domaines étant spécifique pour un antigène de surface présent sur un lymphocyte T d'intérêt. L'invention concerne également une composition, telle qu'une formulation pharmaceutique comprenant le virus, l'utilisation du virus et des formulations de virus à but thérapeutique, par exemple pour le traitement du cancer. L'invention concerne également des procédés de préparation du virus.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2018</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDB0dHH18w_zDAoNVnAM8nV1UQj3DPFQcPIMDnB19nTzdFYIUXB29fFRcHQO8QxzDPEP4mFgTUvMKU7lhdLcDApuriHOHrqpBfnxqcUFicmpeakl8c6OxgbGJqaG5o6GxkQoAQD6mCXj</recordid><startdate>20180308</startdate><enddate>20180308</enddate><creator>FISHER, KERRY DAVID</creator><creator>FREEDMAN, JOSHUA DAVID</creator><creator>CHAMPION, BRIAN ROBERT</creator><creator>BROMLEY, ALICE CLAIRE NOEL</creator><creator>SEYMOUR, LEONARD WILLIAM</creator><scope>EVB</scope></search><sort><creationdate>20180308</creationdate><title>ADENOVIRUS ARMED WITH BISPECIFIC T CELL ACTIVATOR</title><author>FISHER, KERRY DAVID ; FREEDMAN, JOSHUA DAVID ; CHAMPION, BRIAN ROBERT ; BROMLEY, ALICE CLAIRE NOEL ; SEYMOUR, LEONARD WILLIAM</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CA3034517A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2018</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>FISHER, KERRY DAVID</creatorcontrib><creatorcontrib>FREEDMAN, JOSHUA DAVID</creatorcontrib><creatorcontrib>CHAMPION, BRIAN ROBERT</creatorcontrib><creatorcontrib>BROMLEY, ALICE CLAIRE NOEL</creatorcontrib><creatorcontrib>SEYMOUR, LEONARD WILLIAM</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>FISHER, KERRY DAVID</au><au>FREEDMAN, JOSHUA DAVID</au><au>CHAMPION, BRIAN ROBERT</au><au>BROMLEY, ALICE CLAIRE NOEL</au><au>SEYMOUR, LEONARD WILLIAM</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>ADENOVIRUS ARMED WITH BISPECIFIC T CELL ACTIVATOR</title><date>2018-03-08</date><risdate>2018</risdate><abstract>A modified adenovirus, in particular Enadenotucirev (EnAd), armed with a bispecific T cell engager (BiTE) comprising at least two binding domains, wherein at least one of the domains is specific for a surface antigen on a T-cell of interest. Also provided are a composition, such as a pharmaceutical formulation comprising the virus, use of the virus and virus formulations for treatment, such as in the treatment of cancer. The disclosure also extends to processes for preparing the virus.
L'invention concerne un adénovirus modifié, en particulier l'énadénotucirev (EnAd), équipé d'un activateur de lymphocytes T bispécifique (BiTE) comprenant au moins deux domaines de liaison, au moins l'un des domaines étant spécifique pour un antigène de surface présent sur un lymphocyte T d'intérêt. L'invention concerne également une composition, telle qu'une formulation pharmaceutique comprenant le virus, l'utilisation du virus et des formulations de virus à but thérapeutique, par exemple pour le traitement du cancer. L'invention concerne également des procédés de préparation du virus.</abstract><oa>free_for_read</oa></addata></record> |
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| language | eng ; fre |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE |
| title | ADENOVIRUS ARMED WITH BISPECIFIC T CELL ACTIVATOR |
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