6,7-DIHYDRO-5H-PYRAZOLO[5,1-B][1,3]OXAZINE-2-CARBOXAMIDE COMPOUNDS

The present invention is directed to PDE4B inhibitors of Formula I: (I) or a pharmaceutically acceptable salt thereof, wherein the substituents R1, R2, R 3, and R 4are as defined herein. The invention is also directed to pharmaceutical compositions comprising the compounds, methods of treatment usin...

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Bibliographische Detailangaben
Hauptverfasser:	VERHOEST, PATRICK ROBERT, HELAL, CHRISTOPHER JOHN, WAGER, TRAVIS T, SCIABOLA, SIMONE, HAYWARD, MATTHEW MERRILL, LACHAPELLE, ERIK ALPHIE, PATEL, NANDINI CHATURBHAI, CHAPPIE, THOMAS ALLEN
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY ELECTRICITY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention is directed to PDE4B inhibitors of Formula I: (I) or a pharmaceutically acceptable salt thereof, wherein the substituents R1, R2, R 3, and R 4are as defined herein. The invention is also directed to pharmaceutical compositions comprising the compounds, methods of treatment using the compounds, and methods of preparing the compounds. La présente invention concerne des inhibiteurs PDE4B de formule I:(I) ou un sel pharmaceutiquement acceptable de ceux-ci, les substituants R1 , R2, R3, R4 étant tels que définis dans la description. L'invention concerne également des compositions pharmaceutiques comprenant lesdits composés, des méthodes de traitement utilisant ces composés et des procédés de préparation de ces composés.