OXA SPIRO DERIVATIVE, PREPARATION METHOD THEREFOR, AND APPLICATIONS THEREOF IN MEDICINES
The present invention relates to an oxa spiro derivative, a preparation method therefor, and applications thereof in medicines. Particularly, the present invention relates to an oxa spiro derivative represented by formula (I), a preparation method therefor, and a pharmaceutical composition comprisin...
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| creator | HE, MINGXUN CHEN, YANG LI, XIN HE, FENG SUN, PIAOYANG FENG, BINQIANG LIU, TAO TAO, WEIKANG |
| description | The present invention relates to an oxa spiro derivative, a preparation method therefor, and applications thereof in medicines. Particularly, the present invention relates to an oxa spiro derivative represented by formula (I), a preparation method therefor, and a pharmaceutical composition comprising the derivative, applications thereof as an MOR receptor agonist, and applications in the preparation of drugs for treating and/or preventing pains and pains-related diseases. Substituent groups in the formula (I) are same as definitions in the specifications.
La présente invention concerne un dérivé oxa spiro, son procédé de préparation et ses applications dans des médicaments. La présente invention concerne en particulier un dérivé oxa spiro de formule (I), son procédé de préparation, et une composition pharmaceutique comprenant le dérivé, ses applications en tant qu'agoniste du récepteur MOR, et ses applications dans la préparation de médicaments pour traiter et/ou prévenir les douleurs et les maladies liées aux douleurs. Les groupes substituants dans la formule (I) sont tels que définis dans la description. |
| format | Patent |
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La présente invention concerne un dérivé oxa spiro, son procédé de préparation et ses applications dans des médicaments. La présente invention concerne en particulier un dérivé oxa spiro de formule (I), son procédé de préparation, et une composition pharmaceutique comprenant le dérivé, ses applications en tant qu'agoniste du récepteur MOR, et ses applications dans la préparation de médicaments pour traiter et/ou prévenir les douleurs et les maladies liées aux douleurs. Les groupes substituants dans la formule (I) sont tels que définis dans la description.</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240213&DB=EPODOC&CC=CA&NR=3000761C$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76516</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240213&DB=EPODOC&CC=CA&NR=3000761C$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>HE, MINGXUN</creatorcontrib><creatorcontrib>CHEN, YANG</creatorcontrib><creatorcontrib>LI, XIN</creatorcontrib><creatorcontrib>HE, FENG</creatorcontrib><creatorcontrib>SUN, PIAOYANG</creatorcontrib><creatorcontrib>FENG, BINQIANG</creatorcontrib><creatorcontrib>LIU, TAO</creatorcontrib><creatorcontrib>TAO, WEIKANG</creatorcontrib><title>OXA SPIRO DERIVATIVE, PREPARATION METHOD THEREFOR, AND APPLICATIONS THEREOF IN MEDICINES</title><description>The present invention relates to an oxa spiro derivative, a preparation method therefor, and applications thereof in medicines. Particularly, the present invention relates to an oxa spiro derivative represented by formula (I), a preparation method therefor, and a pharmaceutical composition comprising the derivative, applications thereof as an MOR receptor agonist, and applications in the preparation of drugs for treating and/or preventing pains and pains-related diseases. Substituent groups in the formula (I) are same as definitions in the specifications.
La présente invention concerne un dérivé oxa spiro, son procédé de préparation et ses applications dans des médicaments. La présente invention concerne en particulier un dérivé oxa spiro de formule (I), son procédé de préparation, et une composition pharmaceutique comprenant le dérivé, ses applications en tant qu'agoniste du récepteur MOR, et ses applications dans la préparation de médicaments pour traiter et/ou prévenir les douleurs et les maladies liées aux douleurs. Les groupes substituants dans la formule (I) sont tels que définis dans la description.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZIjwj3BUCA7wDPJXcHEN8gxzDPEMc9VRCAhyDXAMAnL8_RR8XUM8_F0UQjxcg1zd_IN0FBz9XBQcAwJ8PJ3BCoIhUv5uCp4gxS6ezp5-rsE8DKxpiTnFqbxQmptB3s01xNlDN7UgPz61uCAxOTUvtSTe2dHYwMDA3MzQ2ZiwCgAwlzA7</recordid><startdate>20240213</startdate><enddate>20240213</enddate><creator>HE, MINGXUN</creator><creator>CHEN, YANG</creator><creator>LI, XIN</creator><creator>HE, FENG</creator><creator>SUN, PIAOYANG</creator><creator>FENG, BINQIANG</creator><creator>LIU, TAO</creator><creator>TAO, WEIKANG</creator><scope>EVB</scope></search><sort><creationdate>20240213</creationdate><title>OXA SPIRO DERIVATIVE, PREPARATION METHOD THEREFOR, AND APPLICATIONS THEREOF IN MEDICINES</title><author>HE, MINGXUN ; CHEN, YANG ; LI, XIN ; HE, FENG ; SUN, PIAOYANG ; FENG, BINQIANG ; LIU, TAO ; TAO, WEIKANG</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CA3000761C3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2024</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>HE, MINGXUN</creatorcontrib><creatorcontrib>CHEN, YANG</creatorcontrib><creatorcontrib>LI, XIN</creatorcontrib><creatorcontrib>HE, FENG</creatorcontrib><creatorcontrib>SUN, PIAOYANG</creatorcontrib><creatorcontrib>FENG, BINQIANG</creatorcontrib><creatorcontrib>LIU, TAO</creatorcontrib><creatorcontrib>TAO, WEIKANG</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>HE, MINGXUN</au><au>CHEN, YANG</au><au>LI, XIN</au><au>HE, FENG</au><au>SUN, PIAOYANG</au><au>FENG, BINQIANG</au><au>LIU, TAO</au><au>TAO, WEIKANG</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>OXA SPIRO DERIVATIVE, PREPARATION METHOD THEREFOR, AND APPLICATIONS THEREOF IN MEDICINES</title><date>2024-02-13</date><risdate>2024</risdate><abstract>The present invention relates to an oxa spiro derivative, a preparation method therefor, and applications thereof in medicines. Particularly, the present invention relates to an oxa spiro derivative represented by formula (I), a preparation method therefor, and a pharmaceutical composition comprising the derivative, applications thereof as an MOR receptor agonist, and applications in the preparation of drugs for treating and/or preventing pains and pains-related diseases. Substituent groups in the formula (I) are same as definitions in the specifications.
La présente invention concerne un dérivé oxa spiro, son procédé de préparation et ses applications dans des médicaments. La présente invention concerne en particulier un dérivé oxa spiro de formule (I), son procédé de préparation, et une composition pharmaceutique comprenant le dérivé, ses applications en tant qu'agoniste du récepteur MOR, et ses applications dans la préparation de médicaments pour traiter et/ou prévenir les douleurs et les maladies liées aux douleurs. Les groupes substituants dans la formule (I) sont tels que définis dans la description.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | OXA SPIRO DERIVATIVE, PREPARATION METHOD THEREFOR, AND APPLICATIONS THEREOF IN MEDICINES |
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