PHARMACEUTICAL FORMULATIONS FOR SUSTAINED RELEASE OF SEBACOYL DINALBUPHINE ESTER
The present invention relates to injectable, extended-release, pharmaceutical formulations comprising a nalbuphine ester prodrug homogenously dissolved in a solution comprising a pharmaceutically acceptable oil and an oil-miscible retaining solvent, as well as manufacturing processes and medical use...
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| creator | KUO, SHU-WEN HUANG, JIN-DING CHOU, DAVID CHIH-KUANG TIEN, YU-EN LI, CHAN-JUNG TSAI, SHIN |
| description | The present invention relates to injectable, extended-release, pharmaceutical formulations comprising a nalbuphine ester prodrug homogenously dissolved in a solution comprising a pharmaceutically acceptable oil and an oil-miscible retaining solvent, as well as manufacturing processes and medical uses of the formulations. The invention further provides methods for adjusting the duration of action of the formulations by varying the ratio of the pharmaceutically acceptable oil and the oil-miscible retaining solvent.
La présente invention concerne des formulations pharmaceutiques injectables à libération prolongée, comprenant un promédicament d'ester de nalbuphine dissous de manière homogène dans une solution comportant une huile pharmaceutiquement acceptable et un solvant de retenue miscible dans l'huile, ainsi que des procédés de fabrication et des utilisations médicales de ces formulations. L'invention concerne en outre des procédés pour l'ajustement de la durée d'action de ces formulations en faisant varier le rapport de l'huile pharmaceutiquement acceptable et du solvant de retenue miscible dans l'huile. |
| format | Patent |
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La présente invention concerne des formulations pharmaceutiques injectables à libération prolongée, comprenant un promédicament d'ester de nalbuphine dissous de manière homogène dans une solution comportant une huile pharmaceutiquement acceptable et un solvant de retenue miscible dans l'huile, ainsi que des procédés de fabrication et des utilisations médicales de ces formulations. L'invention concerne en outre des procédés pour l'ajustement de la durée d'action de ces formulations en faisant varier le rapport de l'huile pharmaceutiquement acceptable et du solvant de retenue miscible dans l'huile.</description><language>eng ; fre</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2023</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230801&DB=EPODOC&CC=CA&NR=2987378C$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25546,76297</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230801&DB=EPODOC&CC=CA&NR=2987378C$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>KUO, SHU-WEN</creatorcontrib><creatorcontrib>HUANG, JIN-DING</creatorcontrib><creatorcontrib>CHOU, DAVID CHIH-KUANG</creatorcontrib><creatorcontrib>TIEN, YU-EN</creatorcontrib><creatorcontrib>LI, CHAN-JUNG</creatorcontrib><creatorcontrib>TSAI, SHIN</creatorcontrib><title>PHARMACEUTICAL FORMULATIONS FOR SUSTAINED RELEASE OF SEBACOYL DINALBUPHINE ESTER</title><description>The present invention relates to injectable, extended-release, pharmaceutical formulations comprising a nalbuphine ester prodrug homogenously dissolved in a solution comprising a pharmaceutically acceptable oil and an oil-miscible retaining solvent, as well as manufacturing processes and medical uses of the formulations. The invention further provides methods for adjusting the duration of action of the formulations by varying the ratio of the pharmaceutically acceptable oil and the oil-miscible retaining solvent.
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La présente invention concerne des formulations pharmaceutiques injectables à libération prolongée, comprenant un promédicament d'ester de nalbuphine dissous de manière homogène dans une solution comportant une huile pharmaceutiquement acceptable et un solvant de retenue miscible dans l'huile, ainsi que des procédés de fabrication et des utilisations médicales de ces formulations. L'invention concerne en outre des procédés pour l'ajustement de la durée d'action de ces formulations en faisant varier le rapport de l'huile pharmaceutiquement acceptable et du solvant de retenue miscible dans l'huile.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | PHARMACEUTICAL FORMULATIONS FOR SUSTAINED RELEASE OF SEBACOYL DINALBUPHINE ESTER |
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