BENZOXAZINONE DERIVATIVES AND ANALOGUES THEREOF AS MODULATORS OF TNF ACTIVITY

A series of substituted 3,4-dihydro-2H-.1,4-benzoxazin-3-one derivatives, and analogues thereof, being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and...

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Hauptverfasser:	CHOVATIA, PRAFULKUMAR TULSHIBHAI, MANDAL, AJAY, JONES, SEVERINE DANIELLE, LECOMTE, FABIEN CLAUDE, PORTER, JOHN ROBERT, JOHNSON, JAMES ANDREW, FOULKES, GREGORY, SMYTH, DONALD, LOWE, MARTIN ALEXANDER, ZHU, ZHAONING, PALMER, CHRISTOPHER FRANCIS, PEREZ-FUERTES, YOLANDA, TRANI, GIANCARLO, NORMAN, TIMOTHY JOHN, KROEPLIEN, BORIS, LOKE, PUI LENG, BRACE, GARETH NEIL, UDDIN, MUHAMMED
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:	A series of substituted 3,4-dihydro-2H-.1,4-benzoxazin-3-one derivatives, and analogues thereof, being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neuradegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders. La présente invention concerne une série de dérivés de 3,4-dihydro-2H-1,4-benzoxazin-3-one substitués, et leurs analogues, qui sont de puissants modulateurs de l'activité du TNF-alpha humain, et donc utiles dans le traitement et/ou la prévention de diverses maladies humaines, notamment les troubles auto-immuns et inflammatoires, les troubles neurologiques et neurodégénératifs, les troubles nociceptifs et la douleur, les troubles cardiovasculaires, les troubles métaboliques, les troubles oculaires et les troubles oncologiques.