CYCLOPROPANE CARBOXYLIC ACID DERIVATIVES AND PHARMACEUTICAL USES THEREOF

There is provided compounds of formula (I), wherein E1, E2, E3, E4, L1, Y1, Y2, Y3, Ra and z have meanings provided in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of leukotriene C4 synthase is desired and...

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Bibliographische Detailangaben
Hauptverfasser:	JOHANNESSON, PETRA, RONN, ROBERT, RINGBERG, ERIK, NILSSON, PETER, LINDH, CARL JONAS, SCHAAL, WESLEY RALPH, NIKITIDIS, ANTONIOS, ANDERSSON, HANNA BIRGITTA ELLINOR, MUNCK AF ROSENSCHOLD, MAGNUS, NIKITIDIS, GRIGORIOS, TYRCHAN, CHRISTIAN
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	There is provided compounds of formula (I), wherein E1, E2, E3, E4, L1, Y1, Y2, Y3, Ra and z have meanings provided in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of leukotriene C4 synthase is desired and/or required, and particularly in the treatment of respiratory diseases and inflammation.