NICOTINIC ACID RIBOSIDE OR NICOTINAMIDE RIBOSIDE COMPOSITIONS, REDUCED DERIVATIVES THEREOF, AND THE USE THEREOF
Derivatives of nicotinic acid riboside (NAR), nicotinamide riboside (NR), and reduced NAR and NR, including 1-(2', 3', 5'-triacetyl-beta-D-ribofuranosyl)-1,4-dihydronicotinic acid (4a), and compositions containing the same and/or reduced derivative forms of nicotinamide riboside inclu...
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| creator | DELLINGER, RYAN REDPATH, PHILIP RHONEMUS, TROY MIGAUD, MARIE CUNNINGHAM, RICHARD |
| description | Derivatives of nicotinic acid riboside (NAR), nicotinamide riboside (NR), and reduced NAR and NR, including 1-(2', 3', 5'-triacetyl-beta-D-ribofuranosyl)-1,4-dihydronicotinic acid (4a), and compositions containing the same and/or reduced derivative forms of nicotinamide riboside including 1-(2',3',5'-triacetyl-beta-D-ribofuranosyl)-1,4-nicotinamide (2), are provided for use in the care of treatment of skin and skin conditions. In some embodiments, the invention relates to pharmaceutical compositions and cosmetic compositions containing one or more NR, NAR, NRH, or NARH derivatives, or prodrugs or salts thereof. In further embodiments, the invention relates to methods of using one or more NR, NAR, NRH, or NARH derivatives, or prodrugs, solvates, or salts thereof, to promote the increase of intracellular levels of nicotinamide adenine dinucleotide (NAD+) in cells and tissues for improving cell and tissue survival and overall cell and tissue health.
L'invention concerne des dérivés de l'acide nicotinique riboside (NAR), du nicotinamide riboside (NR) et de formes réduites de NAR et NR, y compris l'acide 1-(2', 3', 5'-triacétyl-bêta-D-ribofuranosyl)-1,4-dihydronicotinique (4a), ainsi que des compositions contenant ceux-ci et/ou des formes dérivées réduites du nicotinamide riboside y compris le 1-(2',3',5'-triacétyl-bêta-D-ribofuranosyl)-1,4-nicotinamide (2), pour une utilisation dans le soin de traitement de la peau et des maladies de la peau. Dans certains modes de réalisation, l'invention concerne des compositions pharmaceutiques et compositions cosmétiques contenant un ou plusieurs dérivés NR, NAR, NRH ou NARH, ou des promédicaments ou sels de ceux-ci. Dans d'autres modes de réalisation, l'invention concerne des méthodes d'utilisation d'un ou de plusieurs dérivés NR, NAR, NRH ou NARH, ou des promédicaments, solvates ou sels de ceux-ci, utilisés pour promouvoir une augmentation des niveaux intracellulaires de nicotinamide adénine dinucléotide (NAD+) dans les cellules et tissus, afin d'améliorer la survie cellulaire et tissulaire et la santé globale des cellules et tissus. |
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L'invention concerne des dérivés de l'acide nicotinique riboside (NAR), du nicotinamide riboside (NR) et de formes réduites de NAR et NR, y compris l'acide 1-(2', 3', 5'-triacétyl-bêta-D-ribofuranosyl)-1,4-dihydronicotinique (4a), ainsi que des compositions contenant ceux-ci et/ou des formes dérivées réduites du nicotinamide riboside y compris le 1-(2',3',5'-triacétyl-bêta-D-ribofuranosyl)-1,4-nicotinamide (2), pour une utilisation dans le soin de traitement de la peau et des maladies de la peau. Dans certains modes de réalisation, l'invention concerne des compositions pharmaceutiques et compositions cosmétiques contenant un ou plusieurs dérivés NR, NAR, NRH ou NARH, ou des promédicaments ou sels de ceux-ci. Dans d'autres modes de réalisation, l'invention concerne des méthodes d'utilisation d'un ou de plusieurs dérivés NR, NAR, NRH ou NARH, ou des promédicaments, solvates ou sels de ceux-ci, utilisés pour promouvoir une augmentation des niveaux intracellulaires de nicotinamide adénine dinucléotide (NAD+) dans les cellules et tissus, afin d'améliorer la survie cellulaire et tissulaire et la santé globale des cellules et tissus.</description><language>eng ; fre</language><subject>CHEMISTRY ; DERIVATIVES THEREOF ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; NUCLEIC ACIDS ; NUCLEOSIDES ; NUCLEOTIDES ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SUGARS</subject><creationdate>2023</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230124&DB=EPODOC&CC=CA&NR=2979057C$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230124&DB=EPODOC&CC=CA&NR=2979057C$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>DELLINGER, RYAN</creatorcontrib><creatorcontrib>REDPATH, PHILIP</creatorcontrib><creatorcontrib>RHONEMUS, TROY</creatorcontrib><creatorcontrib>MIGAUD, MARIE</creatorcontrib><creatorcontrib>CUNNINGHAM, RICHARD</creatorcontrib><title>NICOTINIC ACID RIBOSIDE OR NICOTINAMIDE RIBOSIDE COMPOSITIONS, REDUCED DERIVATIVES THEREOF, AND THE USE THEREOF</title><description>Derivatives of nicotinic acid riboside (NAR), nicotinamide riboside (NR), and reduced NAR and NR, including 1-(2', 3', 5'-triacetyl-beta-D-ribofuranosyl)-1,4-dihydronicotinic acid (4a), and compositions containing the same and/or reduced derivative forms of nicotinamide riboside including 1-(2',3',5'-triacetyl-beta-D-ribofuranosyl)-1,4-nicotinamide (2), are provided for use in the care of treatment of skin and skin conditions. In some embodiments, the invention relates to pharmaceutical compositions and cosmetic compositions containing one or more NR, NAR, NRH, or NARH derivatives, or prodrugs or salts thereof. In further embodiments, the invention relates to methods of using one or more NR, NAR, NRH, or NARH derivatives, or prodrugs, solvates, or salts thereof, to promote the increase of intracellular levels of nicotinamide adenine dinucleotide (NAD+) in cells and tissues for improving cell and tissue survival and overall cell and tissue health.
L'invention concerne des dérivés de l'acide nicotinique riboside (NAR), du nicotinamide riboside (NR) et de formes réduites de NAR et NR, y compris l'acide 1-(2', 3', 5'-triacétyl-bêta-D-ribofuranosyl)-1,4-dihydronicotinique (4a), ainsi que des compositions contenant ceux-ci et/ou des formes dérivées réduites du nicotinamide riboside y compris le 1-(2',3',5'-triacétyl-bêta-D-ribofuranosyl)-1,4-nicotinamide (2), pour une utilisation dans le soin de traitement de la peau et des maladies de la peau. Dans certains modes de réalisation, l'invention concerne des compositions pharmaceutiques et compositions cosmétiques contenant un ou plusieurs dérivés NR, NAR, NRH ou NARH, ou des promédicaments ou sels de ceux-ci. Dans d'autres modes de réalisation, l'invention concerne des méthodes d'utilisation d'un ou de plusieurs dérivés NR, NAR, NRH ou NARH, ou des promédicaments, solvates ou sels de ceux-ci, utilisés pour promouvoir une augmentation des niveaux intracellulaires de nicotinamide adénine dinucléotide (NAD+) dans les cellules et tissus, afin d'améliorer la survie cellulaire et tissulaire et la santé globale des cellules et tissus.</description><subject>CHEMISTRY</subject><subject>DERIVATIVES THEREOF</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>NUCLEIC ACIDS</subject><subject>NUCLEOSIDES</subject><subject>NUCLEOTIDES</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SUGARS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2023</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqFirEKwkAQRNNYiPoN7gdEEEVCynN3Q7bIrdxd0oYgZyUmEP8fE4i2NjPzZmad9FZQg0wKBoXAyVW9EIM6WCZTzfwbUKvblIKo9Sk4phqZgNhJY4I07CGU7FiLFIylGaD2_C23yerRPce4W3yT7AsOWB7i0LdxHLp7fMV3i-aUZ_nxkuH5_-MDtNU2jg</recordid><startdate>20230124</startdate><enddate>20230124</enddate><creator>DELLINGER, RYAN</creator><creator>REDPATH, PHILIP</creator><creator>RHONEMUS, TROY</creator><creator>MIGAUD, MARIE</creator><creator>CUNNINGHAM, RICHARD</creator><scope>EVB</scope></search><sort><creationdate>20230124</creationdate><title>NICOTINIC ACID RIBOSIDE OR NICOTINAMIDE RIBOSIDE COMPOSITIONS, REDUCED DERIVATIVES THEREOF, AND THE USE THEREOF</title><author>DELLINGER, RYAN ; REDPATH, PHILIP ; RHONEMUS, TROY ; MIGAUD, MARIE ; CUNNINGHAM, RICHARD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CA2979057C3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2023</creationdate><topic>CHEMISTRY</topic><topic>DERIVATIVES THEREOF</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>NUCLEIC ACIDS</topic><topic>NUCLEOSIDES</topic><topic>NUCLEOTIDES</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SUGARS</topic><toplevel>online_resources</toplevel><creatorcontrib>DELLINGER, RYAN</creatorcontrib><creatorcontrib>REDPATH, PHILIP</creatorcontrib><creatorcontrib>RHONEMUS, TROY</creatorcontrib><creatorcontrib>MIGAUD, MARIE</creatorcontrib><creatorcontrib>CUNNINGHAM, RICHARD</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>DELLINGER, RYAN</au><au>REDPATH, PHILIP</au><au>RHONEMUS, TROY</au><au>MIGAUD, MARIE</au><au>CUNNINGHAM, RICHARD</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>NICOTINIC ACID RIBOSIDE OR NICOTINAMIDE RIBOSIDE COMPOSITIONS, REDUCED DERIVATIVES THEREOF, AND THE USE THEREOF</title><date>2023-01-24</date><risdate>2023</risdate><abstract>Derivatives of nicotinic acid riboside (NAR), nicotinamide riboside (NR), and reduced NAR and NR, including 1-(2', 3', 5'-triacetyl-beta-D-ribofuranosyl)-1,4-dihydronicotinic acid (4a), and compositions containing the same and/or reduced derivative forms of nicotinamide riboside including 1-(2',3',5'-triacetyl-beta-D-ribofuranosyl)-1,4-nicotinamide (2), are provided for use in the care of treatment of skin and skin conditions. In some embodiments, the invention relates to pharmaceutical compositions and cosmetic compositions containing one or more NR, NAR, NRH, or NARH derivatives, or prodrugs or salts thereof. In further embodiments, the invention relates to methods of using one or more NR, NAR, NRH, or NARH derivatives, or prodrugs, solvates, or salts thereof, to promote the increase of intracellular levels of nicotinamide adenine dinucleotide (NAD+) in cells and tissues for improving cell and tissue survival and overall cell and tissue health.
L'invention concerne des dérivés de l'acide nicotinique riboside (NAR), du nicotinamide riboside (NR) et de formes réduites de NAR et NR, y compris l'acide 1-(2', 3', 5'-triacétyl-bêta-D-ribofuranosyl)-1,4-dihydronicotinique (4a), ainsi que des compositions contenant ceux-ci et/ou des formes dérivées réduites du nicotinamide riboside y compris le 1-(2',3',5'-triacétyl-bêta-D-ribofuranosyl)-1,4-nicotinamide (2), pour une utilisation dans le soin de traitement de la peau et des maladies de la peau. Dans certains modes de réalisation, l'invention concerne des compositions pharmaceutiques et compositions cosmétiques contenant un ou plusieurs dérivés NR, NAR, NRH ou NARH, ou des promédicaments ou sels de ceux-ci. Dans d'autres modes de réalisation, l'invention concerne des méthodes d'utilisation d'un ou de plusieurs dérivés NR, NAR, NRH ou NARH, ou des promédicaments, solvates ou sels de ceux-ci, utilisés pour promouvoir une augmentation des niveaux intracellulaires de nicotinamide adénine dinucléotide (NAD+) dans les cellules et tissus, afin d'améliorer la survie cellulaire et tissulaire et la santé globale des cellules et tissus.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SUGARS |
| title | NICOTINIC ACID RIBOSIDE OR NICOTINAMIDE RIBOSIDE COMPOSITIONS, REDUCED DERIVATIVES THEREOF, AND THE USE THEREOF |
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