NOVEL FXR (NR1H4) MODULATING COMPOUNDS
The present invention relates to compounds which bind to the NR1 H4 receptor (FXR) and act as agonists of FXR. The invention further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by sai...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng ; fre |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | KINZEL, OLAF SCHMITT, AARON C GEGE, CHRISTIAN KROPF, JEFFREY E XU, JIANJUN BLOMGREN, PETER A KREMOSER, CLAUS WATKINS, WILLIAM J CURRIE, KEVIN S |
| description | The present invention relates to compounds which bind to the NR1 H4 receptor (FXR) and act as agonists of FXR. The invention further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds and to a process for the synthesis of said compounds.
La présente invention concerne des composés qui se lient au récepteur NR1 H4 (FXR) et qui agissent comme des agonistes de FXR. L'invention concerne en outre l'utilisation des composés pour la préparation d'un médicament destiné au traitement de maladies et/ou de conditions par le biais de la liaison dudit récepteur nucléaire par lesdits composés, ainsi qu'un procédé de synthèse desdits composés. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_CA2971241C</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>CA2971241C</sourcerecordid><originalsourceid>FETCH-epo_espacenet_CA2971241C3</originalsourceid><addsrcrecordid>eNrjZFDz8w9z9VFwiwhS0PALMvQw0VTw9XcJ9XEM8fRzV3D29w3wD_VzCeZhYE1LzClO5YXS3Azybq4hzh66qQX58anFBYnJqXmpJfHOjkaW5oZGJobOxoRVAAAbYCJl</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>NOVEL FXR (NR1H4) MODULATING COMPOUNDS</title><source>esp@cenet</source><creator>KINZEL, OLAF ; SCHMITT, AARON C ; GEGE, CHRISTIAN ; KROPF, JEFFREY E ; XU, JIANJUN ; BLOMGREN, PETER A ; KREMOSER, CLAUS ; WATKINS, WILLIAM J ; CURRIE, KEVIN S</creator><creatorcontrib>KINZEL, OLAF ; SCHMITT, AARON C ; GEGE, CHRISTIAN ; KROPF, JEFFREY E ; XU, JIANJUN ; BLOMGREN, PETER A ; KREMOSER, CLAUS ; WATKINS, WILLIAM J ; CURRIE, KEVIN S</creatorcontrib><description>The present invention relates to compounds which bind to the NR1 H4 receptor (FXR) and act as agonists of FXR. The invention further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds and to a process for the synthesis of said compounds.
La présente invention concerne des composés qui se lient au récepteur NR1 H4 (FXR) et qui agissent comme des agonistes de FXR. L'invention concerne en outre l'utilisation des composés pour la préparation d'un médicament destiné au traitement de maladies et/ou de conditions par le biais de la liaison dudit récepteur nucléaire par lesdits composés, ainsi qu'un procédé de synthèse desdits composés.</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2021</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210622&DB=EPODOC&CC=CA&NR=2971241C$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210622&DB=EPODOC&CC=CA&NR=2971241C$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>KINZEL, OLAF</creatorcontrib><creatorcontrib>SCHMITT, AARON C</creatorcontrib><creatorcontrib>GEGE, CHRISTIAN</creatorcontrib><creatorcontrib>KROPF, JEFFREY E</creatorcontrib><creatorcontrib>XU, JIANJUN</creatorcontrib><creatorcontrib>BLOMGREN, PETER A</creatorcontrib><creatorcontrib>KREMOSER, CLAUS</creatorcontrib><creatorcontrib>WATKINS, WILLIAM J</creatorcontrib><creatorcontrib>CURRIE, KEVIN S</creatorcontrib><title>NOVEL FXR (NR1H4) MODULATING COMPOUNDS</title><description>The present invention relates to compounds which bind to the NR1 H4 receptor (FXR) and act as agonists of FXR. The invention further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds and to a process for the synthesis of said compounds.
La présente invention concerne des composés qui se lient au récepteur NR1 H4 (FXR) et qui agissent comme des agonistes de FXR. L'invention concerne en outre l'utilisation des composés pour la préparation d'un médicament destiné au traitement de maladies et/ou de conditions par le biais de la liaison dudit récepteur nucléaire par lesdits composés, ainsi qu'un procédé de synthèse desdits composés.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2021</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFDz8w9z9VFwiwhS0PALMvQw0VTw9XcJ9XEM8fRzV3D29w3wD_VzCeZhYE1LzClO5YXS3Azybq4hzh66qQX58anFBYnJqXmpJfHOjkaW5oZGJobOxoRVAAAbYCJl</recordid><startdate>20210622</startdate><enddate>20210622</enddate><creator>KINZEL, OLAF</creator><creator>SCHMITT, AARON C</creator><creator>GEGE, CHRISTIAN</creator><creator>KROPF, JEFFREY E</creator><creator>XU, JIANJUN</creator><creator>BLOMGREN, PETER A</creator><creator>KREMOSER, CLAUS</creator><creator>WATKINS, WILLIAM J</creator><creator>CURRIE, KEVIN S</creator><scope>EVB</scope></search><sort><creationdate>20210622</creationdate><title>NOVEL FXR (NR1H4) MODULATING COMPOUNDS</title><author>KINZEL, OLAF ; SCHMITT, AARON C ; GEGE, CHRISTIAN ; KROPF, JEFFREY E ; XU, JIANJUN ; BLOMGREN, PETER A ; KREMOSER, CLAUS ; WATKINS, WILLIAM J ; CURRIE, KEVIN S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CA2971241C3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2021</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>KINZEL, OLAF</creatorcontrib><creatorcontrib>SCHMITT, AARON C</creatorcontrib><creatorcontrib>GEGE, CHRISTIAN</creatorcontrib><creatorcontrib>KROPF, JEFFREY E</creatorcontrib><creatorcontrib>XU, JIANJUN</creatorcontrib><creatorcontrib>BLOMGREN, PETER A</creatorcontrib><creatorcontrib>KREMOSER, CLAUS</creatorcontrib><creatorcontrib>WATKINS, WILLIAM J</creatorcontrib><creatorcontrib>CURRIE, KEVIN S</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>KINZEL, OLAF</au><au>SCHMITT, AARON C</au><au>GEGE, CHRISTIAN</au><au>KROPF, JEFFREY E</au><au>XU, JIANJUN</au><au>BLOMGREN, PETER A</au><au>KREMOSER, CLAUS</au><au>WATKINS, WILLIAM J</au><au>CURRIE, KEVIN S</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>NOVEL FXR (NR1H4) MODULATING COMPOUNDS</title><date>2021-06-22</date><risdate>2021</risdate><abstract>The present invention relates to compounds which bind to the NR1 H4 receptor (FXR) and act as agonists of FXR. The invention further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds and to a process for the synthesis of said compounds.
La présente invention concerne des composés qui se lient au récepteur NR1 H4 (FXR) et qui agissent comme des agonistes de FXR. L'invention concerne en outre l'utilisation des composés pour la préparation d'un médicament destiné au traitement de maladies et/ou de conditions par le biais de la liaison dudit récepteur nucléaire par lesdits composés, ainsi qu'un procédé de synthèse desdits composés.</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng ; fre |
| recordid | cdi_epo_espacenet_CA2971241C |
| source | esp@cenet |
| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | NOVEL FXR (NR1H4) MODULATING COMPOUNDS |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-11T13%3A38%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=KINZEL,%20OLAF&rft.date=2021-06-22&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3ECA2971241C%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |