2,2,2-TRIFLUOROETHYL-THIADIAZINES
The present invention provides a compound of formula (I) having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylacti...
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| creator | GUBA, WOLFGANG ANSELM, LILLI WOLTERING, THOMAS HAAP, WOLFGANG PETERS, JENS-UWE BARTELS, BJOERN OBST SANDER, ULRIKE ROGERS-EVANS, MARK DOLENTE, COSIMO |
| description | The present invention provides a compound of formula (I) having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease.
L'invention concerne un composé de formule (I) ayant une activité d'inhibition de la BACE1. Elle concerne sa fabrication, des compositions pharmaceutiques le contenant et son utilisation comme substance thérapeutiquement active. Les composés actifs de l'invention sont utiles dans le traitement thérapeutique et/ou prophylactique de la maladie d'Alzheimer, par exemple. |
| format | Patent |
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L'invention concerne un composé de formule (I) ayant une activité d'inhibition de la BACE1. Elle concerne sa fabrication, des compositions pharmaceutiques le contenant et son utilisation comme substance thérapeutiquement active. Les composés actifs de l'invention sont utiles dans le traitement thérapeutique et/ou prophylactique de la maladie d'Alzheimer, par exemple.</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2016</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20160218&DB=EPODOC&CC=CA&NR=2952160A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20160218&DB=EPODOC&CC=CA&NR=2952160A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>GUBA, WOLFGANG</creatorcontrib><creatorcontrib>ANSELM, LILLI</creatorcontrib><creatorcontrib>WOLTERING, THOMAS</creatorcontrib><creatorcontrib>HAAP, WOLFGANG</creatorcontrib><creatorcontrib>PETERS, JENS-UWE</creatorcontrib><creatorcontrib>BARTELS, BJOERN</creatorcontrib><creatorcontrib>OBST SANDER, ULRIKE</creatorcontrib><creatorcontrib>ROGERS-EVANS, MARK</creatorcontrib><creatorcontrib>DOLENTE, COSIMO</creatorcontrib><title>2,2,2-TRIFLUOROETHYL-THIADIAZINES</title><description>The present invention provides a compound of formula (I) having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease.
L'invention concerne un composé de formule (I) ayant une activité d'inhibition de la BACE1. Elle concerne sa fabrication, des compositions pharmaceutiques le contenant et son utilisation comme substance thérapeutiquement active. Les composés actifs de l'invention sont utiles dans le traitement thérapeutique et/ou prophylactique de la maladie d'Alzheimer, par exemple.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2016</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFA00gFC3ZAgTzefUP8gf9cQj0gf3RAPT0cXT8coTz_XYB4G1rTEnOJUXijNzaDg5hri7KGbWpAfn1pckJicmpdaEu_saGRpamRoZuBoaEyEEgDEHSGR</recordid><startdate>20160218</startdate><enddate>20160218</enddate><creator>GUBA, WOLFGANG</creator><creator>ANSELM, LILLI</creator><creator>WOLTERING, THOMAS</creator><creator>HAAP, WOLFGANG</creator><creator>PETERS, JENS-UWE</creator><creator>BARTELS, BJOERN</creator><creator>OBST SANDER, ULRIKE</creator><creator>ROGERS-EVANS, MARK</creator><creator>DOLENTE, COSIMO</creator><scope>EVB</scope></search><sort><creationdate>20160218</creationdate><title>2,2,2-TRIFLUOROETHYL-THIADIAZINES</title><author>GUBA, WOLFGANG ; ANSELM, LILLI ; WOLTERING, THOMAS ; HAAP, WOLFGANG ; PETERS, JENS-UWE ; BARTELS, BJOERN ; OBST SANDER, ULRIKE ; ROGERS-EVANS, MARK ; DOLENTE, COSIMO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CA2952160A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2016</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>GUBA, WOLFGANG</creatorcontrib><creatorcontrib>ANSELM, LILLI</creatorcontrib><creatorcontrib>WOLTERING, THOMAS</creatorcontrib><creatorcontrib>HAAP, WOLFGANG</creatorcontrib><creatorcontrib>PETERS, JENS-UWE</creatorcontrib><creatorcontrib>BARTELS, BJOERN</creatorcontrib><creatorcontrib>OBST SANDER, ULRIKE</creatorcontrib><creatorcontrib>ROGERS-EVANS, MARK</creatorcontrib><creatorcontrib>DOLENTE, COSIMO</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>GUBA, WOLFGANG</au><au>ANSELM, LILLI</au><au>WOLTERING, THOMAS</au><au>HAAP, WOLFGANG</au><au>PETERS, JENS-UWE</au><au>BARTELS, BJOERN</au><au>OBST SANDER, ULRIKE</au><au>ROGERS-EVANS, MARK</au><au>DOLENTE, COSIMO</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>2,2,2-TRIFLUOROETHYL-THIADIAZINES</title><date>2016-02-18</date><risdate>2016</risdate><abstract>The present invention provides a compound of formula (I) having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease.
L'invention concerne un composé de formule (I) ayant une activité d'inhibition de la BACE1. Elle concerne sa fabrication, des compositions pharmaceutiques le contenant et son utilisation comme substance thérapeutiquement active. Les composés actifs de l'invention sont utiles dans le traitement thérapeutique et/ou prophylactique de la maladie d'Alzheimer, par exemple.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | 2,2,2-TRIFLUOROETHYL-THIADIAZINES |
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