2,2,2-TRIFLUOROETHYL-THIADIAZINES

The present invention provides a compound of formula (I) having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylacti...

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Bibliographische Detailangaben
Hauptverfasser:	GUBA, WOLFGANG, ANSELM, LILLI, WOLTERING, THOMAS, HAAP, WOLFGANG, PETERS, JENS-UWE, BARTELS, BJOERN, OBST SANDER, ULRIKE, ROGERS-EVANS, MARK, DOLENTE, COSIMO
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The present invention provides a compound of formula (I) having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease. L'invention concerne un composé de formule (I) ayant une activité d'inhibition de la BACE1. Elle concerne sa fabrication, des compositions pharmaceutiques le contenant et son utilisation comme substance thérapeutiquement active. Les composés actifs de l'invention sont utiles dans le traitement thérapeutique et/ou prophylactique de la maladie d'Alzheimer, par exemple.