METHOD FOR THE SYNTHESIS OF CLOFARABINE
Method for the production of the anticancer nucleoside clofarabine in high yield, the method comprising the preparation of 2- chloroadenosine by enzymatic transglycosylation between 2- chloroadenine and nucleosides, benzoylation, isomerization, sulfonate ester formation, fluorination, and deprotecti...
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| creator | MATVIENKO, VICTOR SYPCHENKO, VOLODYMYR ZABUDKIN, ALEXANDER MATVIIENKO, IAROSLAV |
| description | Method for the production of the anticancer nucleoside clofarabine in high yield, the method comprising the preparation of 2- chloroadenosine by enzymatic transglycosylation between 2- chloroadenine and nucleosides, benzoylation, isomerization, sulfonate ester formation, fluorination, and deprotection.
On décrit un procédé de production à rendement élevé de la clofarabine, un analogue nucléosidique anticancéreux. Le procédé consiste à préparer 2-chloroadénosine par: transglycosylation enzymatique entre 2-chloroadénine et des nucléosides, benzoylation, isomérisation, formation d'ester de sulfonate, fluoration et déprotection. |
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On décrit un procédé de production à rendement élevé de la clofarabine, un analogue nucléosidique anticancéreux. Le procédé consiste à préparer 2-chloroadénosine par: transglycosylation enzymatique entre 2-chloroadénine et des nucléosides, benzoylation, isomérisation, formation d'ester de sulfonate, fluoration et déprotection.</description><language>eng ; fre</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; DERIVATIVES THEREOF ; ENZYMOLOGY ; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE ; METALLURGY ; MICROBIOLOGY ; MUTATION OR GENETIC ENGINEERING ; NUCLEIC ACIDS ; NUCLEOSIDES ; NUCLEOTIDES ; ORGANIC CHEMISTRY ; SPIRITS ; SUGARS ; VINEGAR ; WINE</subject><creationdate>2019</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190115&DB=EPODOC&CC=CA&NR=2945198C$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76418</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190115&DB=EPODOC&CC=CA&NR=2945198C$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>MATVIENKO, VICTOR</creatorcontrib><creatorcontrib>SYPCHENKO, VOLODYMYR</creatorcontrib><creatorcontrib>ZABUDKIN, ALEXANDER</creatorcontrib><creatorcontrib>MATVIIENKO, IAROSLAV</creatorcontrib><title>METHOD FOR THE SYNTHESIS OF CLOFARABINE</title><description>Method for the production of the anticancer nucleoside clofarabine in high yield, the method comprising the preparation of 2- chloroadenosine by enzymatic transglycosylation between 2- chloroadenine and nucleosides, benzoylation, isomerization, sulfonate ester formation, fluorination, and deprotection.
On décrit un procédé de production à rendement élevé de la clofarabine, un analogue nucléosidique anticancéreux. Le procédé consiste à préparer 2-chloroadénosine par: transglycosylation enzymatique entre 2-chloroadénine et des nucléosides, benzoylation, isomérisation, formation d'ester de sulfonate, fluoration et déprotection.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>DERIVATIVES THEREOF</subject><subject>ENZYMOLOGY</subject><subject>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>NUCLEIC ACIDS</subject><subject>NUCLEOSIDES</subject><subject>NUCLEOTIDES</subject><subject>ORGANIC CHEMISTRY</subject><subject>SPIRITS</subject><subject>SUGARS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2019</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFD3dQ3x8HdRcPMPUgjxcFUIjvQDUsGewQr-bgrOPv5ujkGOTp5-rjwMrGmJOcWpvFCam0HezTXE2UM3tSA_PrW4IDE5NS-1JN7Z0cjSxNTQ0sLZmLAKAE6oIt4</recordid><startdate>20190115</startdate><enddate>20190115</enddate><creator>MATVIENKO, VICTOR</creator><creator>SYPCHENKO, VOLODYMYR</creator><creator>ZABUDKIN, ALEXANDER</creator><creator>MATVIIENKO, IAROSLAV</creator><scope>EVB</scope></search><sort><creationdate>20190115</creationdate><title>METHOD FOR THE SYNTHESIS OF CLOFARABINE</title><author>MATVIENKO, VICTOR ; SYPCHENKO, VOLODYMYR ; ZABUDKIN, ALEXANDER ; MATVIIENKO, IAROSLAV</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CA2945198C3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2019</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>DERIVATIVES THEREOF</topic><topic>ENZYMOLOGY</topic><topic>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>NUCLEIC ACIDS</topic><topic>NUCLEOSIDES</topic><topic>NUCLEOTIDES</topic><topic>ORGANIC CHEMISTRY</topic><topic>SPIRITS</topic><topic>SUGARS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>MATVIENKO, VICTOR</creatorcontrib><creatorcontrib>SYPCHENKO, VOLODYMYR</creatorcontrib><creatorcontrib>ZABUDKIN, ALEXANDER</creatorcontrib><creatorcontrib>MATVIIENKO, IAROSLAV</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>MATVIENKO, VICTOR</au><au>SYPCHENKO, VOLODYMYR</au><au>ZABUDKIN, ALEXANDER</au><au>MATVIIENKO, IAROSLAV</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>METHOD FOR THE SYNTHESIS OF CLOFARABINE</title><date>2019-01-15</date><risdate>2019</risdate><abstract>Method for the production of the anticancer nucleoside clofarabine in high yield, the method comprising the preparation of 2- chloroadenosine by enzymatic transglycosylation between 2- chloroadenine and nucleosides, benzoylation, isomerization, sulfonate ester formation, fluorination, and deprotection.
On décrit un procédé de production à rendement élevé de la clofarabine, un analogue nucléosidique anticancéreux. Le procédé consiste à préparer 2-chloroadénosine par: transglycosylation enzymatique entre 2-chloroadénine et des nucléosides, benzoylation, isomérisation, formation d'ester de sulfonate, fluoration et déprotection.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY DERIVATIVES THEREOF ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY SPIRITS SUGARS VINEGAR WINE |
| title | METHOD FOR THE SYNTHESIS OF CLOFARABINE |
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