AMPHOTERICIN B DERIVATIVES WITH IMPROVED THERAPEUTIC INDEX
6 ABTRACT Provided are certain derivatives of amphotericin B (AmB) characterized by reduced toxicity and retained anti-fungal activity. Certain of the derivatives are C16 urea derivatives of AmB. Certain of the derivatives are C3, C5, C8, C9, C11, C13, or C15 deoxy derivatives of AmB. Certain of the...
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| creator | UNO, BRICE E STRUBLE, JUSTIN DAILEY, IAN KNAPP, DAVID M PALYAM, NAGARJUNA BURKE, MARTIN D DAVIS, STEPHEN GRAY, KAITLYN C WANG, PULIN |
| description | 6 ABTRACT Provided are certain derivatives of amphotericin B (AmB) characterized by reduced toxicity and retained anti-fungal activity. Certain of the derivatives are C16 urea derivatives of AmB. Certain of the derivatives are C3, C5, C8, C9, C11, C13, or C15 deoxy derivatives of AmB. Certain of the derivatives include C3' or C4 modifications of the mycosamine appendage of AmB. Also provided are methods of making AmB derivatives of the invention, pharmaceutical compositions comprising AmB derivatives of the invention, and methods of use of AmB derivatives of the invention. OH OH \ 0 HO /Me 0 OH OH OH OH 0, " N NNH2 H H la OH NH2 Date Recue/Date Received 2021-03-16
L'invention concerne certains dérivés d'amphotéricine (AmB) caractérisés par une toxicité réduite et une activité antifongique conservée. Certains des dérivés sont des dérivés d'urée en C16 d'AmB. Certains des dérivés sont des désoxy-dérivés en C3, C5, C8, C9, C11, C13 ou C15 d'AmB. Certains des dérivés comprennent des modifications en C3' ou C4' de l'appendice mycosamine d'AmB. L'invention concerne également des procédés de fabrication des dérivés d'AmB de l'invention, des compositions pharmaceutiques comprenant les dérivés d'AmB de l'invention, et des procédés d'utilisation des dérivés d'AmB de l'invention. |
| format | Patent |
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L'invention concerne certains dérivés d'amphotéricine (AmB) caractérisés par une toxicité réduite et une activité antifongique conservée. Certains des dérivés sont des dérivés d'urée en C16 d'AmB. Certains des dérivés sont des désoxy-dérivés en C3, C5, C8, C9, C11, C13 ou C15 d'AmB. Certains des dérivés comprennent des modifications en C3' ou C4' de l'appendice mycosamine d'AmB. L'invention concerne également des procédés de fabrication des dérivés d'AmB de l'invention, des compositions pharmaceutiques comprenant les dérivés d'AmB de l'invention, et des procédés d'utilisation des dérivés d'AmB de l'invention.</description><language>eng ; fre</language><subject>CHEMISTRY ; DERIVATIVES THEREOF ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; NUCLEIC ACIDS ; NUCLEOSIDES ; NUCLEOTIDES ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SUGARS</subject><creationdate>2021</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20211123&DB=EPODOC&CC=CA&NR=2925904C$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20211123&DB=EPODOC&CC=CA&NR=2925904C$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>UNO, BRICE E</creatorcontrib><creatorcontrib>STRUBLE, JUSTIN</creatorcontrib><creatorcontrib>DAILEY, IAN</creatorcontrib><creatorcontrib>KNAPP, DAVID M</creatorcontrib><creatorcontrib>PALYAM, NAGARJUNA</creatorcontrib><creatorcontrib>BURKE, MARTIN D</creatorcontrib><creatorcontrib>DAVIS, STEPHEN</creatorcontrib><creatorcontrib>GRAY, KAITLYN C</creatorcontrib><creatorcontrib>WANG, PULIN</creatorcontrib><title>AMPHOTERICIN B DERIVATIVES WITH IMPROVED THERAPEUTIC INDEX</title><description>6 ABTRACT Provided are certain derivatives of amphotericin B (AmB) characterized by reduced toxicity and retained anti-fungal activity. Certain of the derivatives are C16 urea derivatives of AmB. Certain of the derivatives are C3, C5, C8, C9, C11, C13, or C15 deoxy derivatives of AmB. Certain of the derivatives include C3' or C4 modifications of the mycosamine appendage of AmB. Also provided are methods of making AmB derivatives of the invention, pharmaceutical compositions comprising AmB derivatives of the invention, and methods of use of AmB derivatives of the invention. OH OH \ 0 HO /Me 0 OH OH OH OH 0, " N NNH2 H H la OH NH2 Date Recue/Date Received 2021-03-16
L'invention concerne certains dérivés d'amphotéricine (AmB) caractérisés par une toxicité réduite et une activité antifongique conservée. Certains des dérivés sont des dérivés d'urée en C16 d'AmB. Certains des dérivés sont des désoxy-dérivés en C3, C5, C8, C9, C11, C13 ou C15 d'AmB. Certains des dérivés comprennent des modifications en C3' ou C4' de l'appendice mycosamine d'AmB. L'invention concerne également des procédés de fabrication des dérivés d'AmB de l'invention, des compositions pharmaceutiques comprenant les dérivés d'AmB de l'invention, et des procédés d'utilisation des dérivés d'AmB de l'invention.</description><subject>CHEMISTRY</subject><subject>DERIVATIVES THEREOF</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>NUCLEIC ACIDS</subject><subject>NUCLEOSIDES</subject><subject>NUCLEOTIDES</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SUGARS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2021</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLBy9A3w8A9xDfJ09vRTcFJwAbLCHEM8w1yDFcI9QzwUPH0DgvzDXF0UQjxcgxwDXENDPJ0VPP1cXCN4GFjTEnOKU3mhNDeDvJtriLOHbmpBfnxqcUFicmpeakm8s6ORpZGppYGJszFhFQAysSho</recordid><startdate>20211123</startdate><enddate>20211123</enddate><creator>UNO, BRICE E</creator><creator>STRUBLE, JUSTIN</creator><creator>DAILEY, IAN</creator><creator>KNAPP, DAVID M</creator><creator>PALYAM, NAGARJUNA</creator><creator>BURKE, MARTIN D</creator><creator>DAVIS, STEPHEN</creator><creator>GRAY, KAITLYN C</creator><creator>WANG, PULIN</creator><scope>EVB</scope></search><sort><creationdate>20211123</creationdate><title>AMPHOTERICIN B DERIVATIVES WITH IMPROVED THERAPEUTIC INDEX</title><author>UNO, BRICE E ; STRUBLE, JUSTIN ; DAILEY, IAN ; KNAPP, DAVID M ; PALYAM, NAGARJUNA ; BURKE, MARTIN D ; DAVIS, STEPHEN ; GRAY, KAITLYN C ; WANG, PULIN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CA2925904C3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2021</creationdate><topic>CHEMISTRY</topic><topic>DERIVATIVES THEREOF</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>NUCLEIC ACIDS</topic><topic>NUCLEOSIDES</topic><topic>NUCLEOTIDES</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SUGARS</topic><toplevel>online_resources</toplevel><creatorcontrib>UNO, BRICE E</creatorcontrib><creatorcontrib>STRUBLE, JUSTIN</creatorcontrib><creatorcontrib>DAILEY, IAN</creatorcontrib><creatorcontrib>KNAPP, DAVID M</creatorcontrib><creatorcontrib>PALYAM, NAGARJUNA</creatorcontrib><creatorcontrib>BURKE, MARTIN D</creatorcontrib><creatorcontrib>DAVIS, STEPHEN</creatorcontrib><creatorcontrib>GRAY, KAITLYN C</creatorcontrib><creatorcontrib>WANG, PULIN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>UNO, BRICE E</au><au>STRUBLE, JUSTIN</au><au>DAILEY, IAN</au><au>KNAPP, DAVID M</au><au>PALYAM, NAGARJUNA</au><au>BURKE, MARTIN D</au><au>DAVIS, STEPHEN</au><au>GRAY, KAITLYN C</au><au>WANG, PULIN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>AMPHOTERICIN B DERIVATIVES WITH IMPROVED THERAPEUTIC INDEX</title><date>2021-11-23</date><risdate>2021</risdate><abstract>6 ABTRACT Provided are certain derivatives of amphotericin B (AmB) characterized by reduced toxicity and retained anti-fungal activity. Certain of the derivatives are C16 urea derivatives of AmB. Certain of the derivatives are C3, C5, C8, C9, C11, C13, or C15 deoxy derivatives of AmB. Certain of the derivatives include C3' or C4 modifications of the mycosamine appendage of AmB. Also provided are methods of making AmB derivatives of the invention, pharmaceutical compositions comprising AmB derivatives of the invention, and methods of use of AmB derivatives of the invention. OH OH \ 0 HO /Me 0 OH OH OH OH 0, " N NNH2 H H la OH NH2 Date Recue/Date Received 2021-03-16
L'invention concerne certains dérivés d'amphotéricine (AmB) caractérisés par une toxicité réduite et une activité antifongique conservée. Certains des dérivés sont des dérivés d'urée en C16 d'AmB. Certains des dérivés sont des désoxy-dérivés en C3, C5, C8, C9, C11, C13 ou C15 d'AmB. Certains des dérivés comprennent des modifications en C3' ou C4' de l'appendice mycosamine d'AmB. L'invention concerne également des procédés de fabrication des dérivés d'AmB de l'invention, des compositions pharmaceutiques comprenant les dérivés d'AmB de l'invention, et des procédés d'utilisation des dérivés d'AmB de l'invention.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS |
| title | AMPHOTERICIN B DERIVATIVES WITH IMPROVED THERAPEUTIC INDEX |
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