COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF INFLAMMATORY DISORDERS
The present invention discloses compounds according to Formula I: Wherein R1a, R1b, R2, R4, R5, R6a, R6b, R7, R8, W, X, Cy, and the subscript a are as defined herein. The present invention relates to compounds inhibiting autotaxin (NPP2 or ENPP2), methods for their production, pharmaceutical composi...
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| creator | HECKMANN, BERTRAND BRYS, REGINALD CHRISTOPHE XAVIER DESROY, NICOLAS PEIXOTO, CHRISTOPHE JONCOUR, AGNES BOCK, XAVIER |
| description | The present invention discloses compounds according to Formula I: Wherein R1a, R1b, R2, R4, R5, R6a, R6b, R7, R8, W, X, Cy, and the subscript a are as defined herein. The present invention relates to compounds inhibiting autotaxin (NPP2 or ENPP2), methods for their production, pharmaceutical compositions comprising the same, and methods of treatment using the same, for the prophylaxis and/or treatment of diseases involving fibrotic diseases, proliferative diseases, inflammatory diseases, autoimmune diseases, respiratory diseases, cardiovascular diseases, neurodegenerative diseases, dermatological disorders, and/or abnormal angiogenesis associated diseasesby administering the compound of the invention.
Cette invention concerne des composés de Formule I : R1a, R1b, R2, R4, R5, R6a, R6b, R7, R8, W, X, Cy, et a en exposant dans la Formule étant tels que définis dans la description. Cette invention concerne également des composés inhibant l'autotaxine (NPP2 ou ENPP2), ainsi que leurs procédés de production, et des compositions pharmaceutiques les contenant. Des méthodes de traitement les utilisant, pour prévenir et/ou traiter des maladies impliquant les maladies fibrotiques, les maladies prolifératives, les maladies inflammatoires, les maladies autoimmunes, les maladies respiratoires, les maladies cardiovasculaires, les maladies neurodégénératives, les affections dermatologiques, et/ou les maladies associées à une angiogenèse anormale par administration du composé selon l'invention sont en outre décrites. |
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Cette invention concerne des composés de Formule I : R1a, R1b, R2, R4, R5, R6a, R6b, R7, R8, W, X, Cy, et a en exposant dans la Formule étant tels que définis dans la description. Cette invention concerne également des composés inhibant l'autotaxine (NPP2 ou ENPP2), ainsi que leurs procédés de production, et des compositions pharmaceutiques les contenant. Des méthodes de traitement les utilisant, pour prévenir et/ou traiter des maladies impliquant les maladies fibrotiques, les maladies prolifératives, les maladies inflammatoires, les maladies autoimmunes, les maladies respiratoires, les maladies cardiovasculaires, les maladies neurodégénératives, les affections dermatologiques, et/ou les maladies associées à une angiogenèse anormale par administration du composé selon l'invention sont en outre décrites.</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2021</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210921&DB=EPODOC&CC=CA&NR=2902103C$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210921&DB=EPODOC&CC=CA&NR=2902103C$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>HECKMANN, BERTRAND</creatorcontrib><creatorcontrib>BRYS, REGINALD CHRISTOPHE XAVIER</creatorcontrib><creatorcontrib>DESROY, NICOLAS</creatorcontrib><creatorcontrib>PEIXOTO, CHRISTOPHE</creatorcontrib><creatorcontrib>JONCOUR, AGNES</creatorcontrib><creatorcontrib>BOCK, XAVIER</creatorcontrib><title>COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF INFLAMMATORY DISORDERS</title><description>The present invention discloses compounds according to Formula I: Wherein R1a, R1b, R2, R4, R5, R6a, R6b, R7, R8, W, X, Cy, and the subscript a are as defined herein. The present invention relates to compounds inhibiting autotaxin (NPP2 or ENPP2), methods for their production, pharmaceutical compositions comprising the same, and methods of treatment using the same, for the prophylaxis and/or treatment of diseases involving fibrotic diseases, proliferative diseases, inflammatory diseases, autoimmune diseases, respiratory diseases, cardiovascular diseases, neurodegenerative diseases, dermatological disorders, and/or abnormal angiogenesis associated diseasesby administering the compound of the invention.
Cette invention concerne des composés de Formule I : R1a, R1b, R2, R4, R5, R6a, R6b, R7, R8, W, X, Cy, et a en exposant dans la Formule étant tels que définis dans la description. Cette invention concerne également des composés inhibant l'autotaxine (NPP2 ou ENPP2), ainsi que leurs procédés de production, et des compositions pharmaceutiques les contenant. Des méthodes de traitement les utilisant, pour prévenir et/ou traiter des maladies impliquant les maladies fibrotiques, les maladies prolifératives, les maladies inflammatoires, les maladies autoimmunes, les maladies respiratoires, les maladies cardiovasculaires, les maladies neurodégénératives, les affections dermatologiques, et/ou les maladies associées à une angiogenèse anormale par administration du composé selon l'invention sont en outre décrites.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2021</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqFirsKwkAQRdNYiPoNzg8IMaksh91ZspDdCbOTwiKEIGslGoj_jw_sre7hnLsuBsOh4z7aBBgtdA1KQEO9eoMtfGPy6jkm0IaE2IFj-TCoEGqgqPCWProWQ0BlOYP1icWSpG2xuk63Je9-uyn2jtQ0hzw_xrzM0yXf83M0WJ3K6ljWpv7_eAFf5zIh</recordid><startdate>20210921</startdate><enddate>20210921</enddate><creator>HECKMANN, BERTRAND</creator><creator>BRYS, REGINALD CHRISTOPHE XAVIER</creator><creator>DESROY, NICOLAS</creator><creator>PEIXOTO, CHRISTOPHE</creator><creator>JONCOUR, AGNES</creator><creator>BOCK, XAVIER</creator><scope>EVB</scope></search><sort><creationdate>20210921</creationdate><title>COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF INFLAMMATORY DISORDERS</title><author>HECKMANN, BERTRAND ; BRYS, REGINALD CHRISTOPHE XAVIER ; DESROY, NICOLAS ; PEIXOTO, CHRISTOPHE ; JONCOUR, AGNES ; BOCK, XAVIER</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CA2902103C3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2021</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>HECKMANN, BERTRAND</creatorcontrib><creatorcontrib>BRYS, REGINALD CHRISTOPHE XAVIER</creatorcontrib><creatorcontrib>DESROY, NICOLAS</creatorcontrib><creatorcontrib>PEIXOTO, CHRISTOPHE</creatorcontrib><creatorcontrib>JONCOUR, AGNES</creatorcontrib><creatorcontrib>BOCK, XAVIER</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>HECKMANN, BERTRAND</au><au>BRYS, REGINALD CHRISTOPHE XAVIER</au><au>DESROY, NICOLAS</au><au>PEIXOTO, CHRISTOPHE</au><au>JONCOUR, AGNES</au><au>BOCK, XAVIER</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF INFLAMMATORY DISORDERS</title><date>2021-09-21</date><risdate>2021</risdate><abstract>The present invention discloses compounds according to Formula I: Wherein R1a, R1b, R2, R4, R5, R6a, R6b, R7, R8, W, X, Cy, and the subscript a are as defined herein. The present invention relates to compounds inhibiting autotaxin (NPP2 or ENPP2), methods for their production, pharmaceutical compositions comprising the same, and methods of treatment using the same, for the prophylaxis and/or treatment of diseases involving fibrotic diseases, proliferative diseases, inflammatory diseases, autoimmune diseases, respiratory diseases, cardiovascular diseases, neurodegenerative diseases, dermatological disorders, and/or abnormal angiogenesis associated diseasesby administering the compound of the invention.
Cette invention concerne des composés de Formule I : R1a, R1b, R2, R4, R5, R6a, R6b, R7, R8, W, X, Cy, et a en exposant dans la Formule étant tels que définis dans la description. Cette invention concerne également des composés inhibant l'autotaxine (NPP2 ou ENPP2), ainsi que leurs procédés de production, et des compositions pharmaceutiques les contenant. Des méthodes de traitement les utilisant, pour prévenir et/ou traiter des maladies impliquant les maladies fibrotiques, les maladies prolifératives, les maladies inflammatoires, les maladies autoimmunes, les maladies respiratoires, les maladies cardiovasculaires, les maladies neurodégénératives, les affections dermatologiques, et/ou les maladies associées à une angiogenèse anormale par administration du composé selon l'invention sont en outre décrites.</abstract><oa>free_for_read</oa></addata></record> |
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| title | COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF INFLAMMATORY DISORDERS |
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