NOVEL N-(2,3-DIHYDRO-1H-PYRROLO[2,3-B]PYRIDIN-5-YL)-4-QUINAZOLINAMINE AND N-(2,3-DIHYDRO-1H-INDOL-5-YL)-4-QUINAZOLINAMINE DERIVATIVES AS PERK INHIBITORS
The present invention relates to N-(2,3-dihydro-1H-pyrrolo[2,3-b)]pyridin-5-yl)-4-quinazolinamine and N-(2.3-dihydro-1H-indol-5-yl)-4-quinazolinamine derivatives of Formula (I) wherein R1, R2, R3, R4, R5, R6 and A have the meaning defined in the claims. The compounds according to the present inventi...
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| creator | STANSFIELD, IAN LIGNY, YANNICK AIME EDDY AMBLARD, NATHALIE CLAUDIE ISABELLE VERSELE, MATTHIAS LUC AIME |
| description | The present invention relates to N-(2,3-dihydro-1H-pyrrolo[2,3-b)]pyridin-5-yl)-4-quinazolinamine and N-(2.3-dihydro-1H-indol-5-yl)-4-quinazolinamine derivatives of Formula (I) wherein R1, R2, R3, R4, R5, R6 and A have the meaning defined in the claims. The compounds according to the present invention are useful as inhibitors of PERK. The invention further relates to processes for preparing such compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
La présente invention concerne des dérivés N-(2,3-dihydro-1H-pyrrolo[2,3-b)]pyridin-5-yl)-4-quinazolinamine et N-(2.3-dihydro-1H-indol-5-yl)-4-quinazolinamine de formule (I) dans laquelle R1, R2, R3, R4, R5, R6 et A ont la signification définie dans les revendications. Les composés selon la présente invention sont utiles en tant qu'inhibiteurs de PERK. L'invention concerne en outre des procédés pour préparer de tels composés, des compositions pharmaceutiques comprenant lesdits composés en tant que principe actif ainsi que l'utilisation desdits composés en tant que médicament. |
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La présente invention concerne des dérivés N-(2,3-dihydro-1H-pyrrolo[2,3-b)]pyridin-5-yl)-4-quinazolinamine et N-(2.3-dihydro-1H-indol-5-yl)-4-quinazolinamine de formule (I) dans laquelle R1, R2, R3, R4, R5, R6 et A ont la signification définie dans les revendications. Les composés selon la présente invention sont utiles en tant qu'inhibiteurs de PERK. L'invention concerne en outre des procédés pour préparer de tels composés, des compositions pharmaceutiques comprenant lesdits composés en tant que principe actif ainsi que l'utilisation desdits composés en tant que médicament.</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2021</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210119&DB=EPODOC&CC=CA&NR=2901267C$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,778,883,25551,76302</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210119&DB=EPODOC&CC=CA&NR=2901267C$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>STANSFIELD, IAN</creatorcontrib><creatorcontrib>LIGNY, YANNICK AIME EDDY</creatorcontrib><creatorcontrib>AMBLARD, NATHALIE CLAUDIE ISABELLE</creatorcontrib><creatorcontrib>VERSELE, MATTHIAS LUC AIME</creatorcontrib><title>NOVEL N-(2,3-DIHYDRO-1H-PYRROLO[2,3-B]PYRIDIN-5-YL)-4-QUINAZOLINAMINE AND N-(2,3-DIHYDRO-1H-INDOL-5-YL)-4-QUINAZOLINAMINE DERIVATIVES AS PERK INHIBITORS</title><description>The present invention relates to N-(2,3-dihydro-1H-pyrrolo[2,3-b)]pyridin-5-yl)-4-quinazolinamine and N-(2.3-dihydro-1H-indol-5-yl)-4-quinazolinamine derivatives of Formula (I) wherein R1, R2, R3, R4, R5, R6 and A have the meaning defined in the claims. The compounds according to the present invention are useful as inhibitors of PERK. The invention further relates to processes for preparing such compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
La présente invention concerne des dérivés N-(2,3-dihydro-1H-pyrrolo[2,3-b)]pyridin-5-yl)-4-quinazolinamine et N-(2.3-dihydro-1H-indol-5-yl)-4-quinazolinamine de formule (I) dans laquelle R1, R2, R3, R4, R5, R6 et A ont la signification définie dans les revendications. Les composés selon la présente invention sont utiles en tant qu'inhibiteurs de PERK. L'invention concerne en outre des procédés pour préparer de tels composés, des compositions pharmaceutiques comprenant lesdits composés en tant que principe actif ainsi que l'utilisation desdits composés en tant que médicament.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2021</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZJjh5x_m6qPgp6thpGOs6-LpEekS5K9r6KEbEBkU5O_jHw0SdooF8jxdPP10TXUjfTR1TXQDQz39HKP8fYCkr6efq4KjnwsWMzz9XPx9cOpxcQ3yDHMM8QxzDVZwDFYIcA3yVvD08_B08gzxDwrmYWBNS8wpTuWF0twM8m6uIc4euqkF-fGpxQWJyal5qSXxzo5GlgaGRmbmzsaEVQAAcY1AqQ</recordid><startdate>20210119</startdate><enddate>20210119</enddate><creator>STANSFIELD, IAN</creator><creator>LIGNY, YANNICK AIME EDDY</creator><creator>AMBLARD, NATHALIE CLAUDIE ISABELLE</creator><creator>VERSELE, MATTHIAS LUC AIME</creator><scope>EVB</scope></search><sort><creationdate>20210119</creationdate><title>NOVEL N-(2,3-DIHYDRO-1H-PYRROLO[2,3-B]PYRIDIN-5-YL)-4-QUINAZOLINAMINE AND N-(2,3-DIHYDRO-1H-INDOL-5-YL)-4-QUINAZOLINAMINE DERIVATIVES AS PERK INHIBITORS</title><author>STANSFIELD, IAN ; LIGNY, YANNICK AIME EDDY ; AMBLARD, NATHALIE CLAUDIE ISABELLE ; VERSELE, MATTHIAS LUC AIME</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CA2901267C3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2021</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>STANSFIELD, IAN</creatorcontrib><creatorcontrib>LIGNY, YANNICK AIME EDDY</creatorcontrib><creatorcontrib>AMBLARD, NATHALIE CLAUDIE ISABELLE</creatorcontrib><creatorcontrib>VERSELE, MATTHIAS LUC AIME</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>STANSFIELD, IAN</au><au>LIGNY, YANNICK AIME EDDY</au><au>AMBLARD, NATHALIE CLAUDIE ISABELLE</au><au>VERSELE, MATTHIAS LUC AIME</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>NOVEL N-(2,3-DIHYDRO-1H-PYRROLO[2,3-B]PYRIDIN-5-YL)-4-QUINAZOLINAMINE AND N-(2,3-DIHYDRO-1H-INDOL-5-YL)-4-QUINAZOLINAMINE DERIVATIVES AS PERK INHIBITORS</title><date>2021-01-19</date><risdate>2021</risdate><abstract>The present invention relates to N-(2,3-dihydro-1H-pyrrolo[2,3-b)]pyridin-5-yl)-4-quinazolinamine and N-(2.3-dihydro-1H-indol-5-yl)-4-quinazolinamine derivatives of Formula (I) wherein R1, R2, R3, R4, R5, R6 and A have the meaning defined in the claims. The compounds according to the present invention are useful as inhibitors of PERK. The invention further relates to processes for preparing such compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
La présente invention concerne des dérivés N-(2,3-dihydro-1H-pyrrolo[2,3-b)]pyridin-5-yl)-4-quinazolinamine et N-(2.3-dihydro-1H-indol-5-yl)-4-quinazolinamine de formule (I) dans laquelle R1, R2, R3, R4, R5, R6 et A ont la signification définie dans les revendications. Les composés selon la présente invention sont utiles en tant qu'inhibiteurs de PERK. L'invention concerne en outre des procédés pour préparer de tels composés, des compositions pharmaceutiques comprenant lesdits composés en tant que principe actif ainsi que l'utilisation desdits composés en tant que médicament.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | NOVEL N-(2,3-DIHYDRO-1H-PYRROLO[2,3-B]PYRIDIN-5-YL)-4-QUINAZOLINAMINE AND N-(2,3-DIHYDRO-1H-INDOL-5-YL)-4-QUINAZOLINAMINE DERIVATIVES AS PERK INHIBITORS |
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