PYRAZOLYLBENZO[D]IMIDAZOLE DERIVATIVES
A compound represented by the general Formula (I), whereinhydrogen atoms shown as attached to pyrazole and benzimidazole rings are attached to one of nitrogen atoms of the pyrazole or benzimidazole ring, respectively; R1 represents -X-Q-P, wherein X is absent or represents CH2-, C(O)-, or C(O)NH-(CH...
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| creator | DUBIEL, KRZYSZTOF STANCZAK, ALEKSANDRA WIECZOREK, MACIEJ GRYGIELEWICZ, PAULINA LIPNER, JOANNA ZDZALIK, DARIA DZWONEK, KAROLINA YAMANI, ABDELLAH LAMPARSKA-PRZYBYSZ, MONIKA |
| description | A compound represented by the general Formula (I), whereinhydrogen atoms shown as attached to pyrazole and benzimidazole rings are attached to one of nitrogen atoms of the pyrazole or benzimidazole ring, respectively; R1 represents -X-Q-P, wherein X is absent or represents CH2-, C(O)-, or C(O)NH-(CH2)k-, wherein k is 0, 1 or 2; Q is selected from the group consisting of Q1, Q2, Q3, Q4 and Q5; P is absent or represents straight-or branched-chain C1-C3 alkyl, (CH2)l-NR2R3, or(CH2)m-C(O)-NR2R3, wherein l and m independently of each other represent 0, 1 or 2, with the proviso that when B in Q1 represents oxygen atom, then P is absent;and R2and R3 independently represent C1 or C2 alkyl, or R2 and R3 together with nitrogen atom to which they are both attached form a 6- membered saturated heterocyclicring, wherein one of carbon atoms can be replaced with oxygen, -NH-or N(C1-C2)alkyl-; and acid addition salts thereof. The compound can be useful in the treatment of cancer diseases. (I) |
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| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_CA2900629A1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>CA2900629A1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_CA2900629A13</originalsourceid><addsrcrecordid>eNrjZFALiAxyjPL3ifRxcvWL8o92ifX09XQBibgquLgGeYY5hniGuQbzMLCmJeYUp_JCaW4GBTfXEGcP3dSC_PjU4oLE5NS81JJ4Z0cjSwMDMyNLR0NjIpQAANgwI98</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>PYRAZOLYLBENZO[D]IMIDAZOLE DERIVATIVES</title><source>esp@cenet</source><creator>DUBIEL, KRZYSZTOF ; STANCZAK, ALEKSANDRA ; WIECZOREK, MACIEJ ; GRYGIELEWICZ, PAULINA ; LIPNER, JOANNA ; ZDZALIK, DARIA ; DZWONEK, KAROLINA ; YAMANI, ABDELLAH ; LAMPARSKA-PRZYBYSZ, MONIKA</creator><creatorcontrib>DUBIEL, KRZYSZTOF ; STANCZAK, ALEKSANDRA ; WIECZOREK, MACIEJ ; GRYGIELEWICZ, PAULINA ; LIPNER, JOANNA ; ZDZALIK, DARIA ; DZWONEK, KAROLINA ; YAMANI, ABDELLAH ; LAMPARSKA-PRZYBYSZ, MONIKA</creatorcontrib><description>A compound represented by the general Formula (I), whereinhydrogen atoms shown as attached to pyrazole and benzimidazole rings are attached to one of nitrogen atoms of the pyrazole or benzimidazole ring, respectively; R1 represents -X-Q-P, wherein X is absent or represents CH2-, C(O)-, or C(O)NH-(CH2)k-, wherein k is 0, 1 or 2; Q is selected from the group consisting of Q1, Q2, Q3, Q4 and Q5; P is absent or represents straight-or branched-chain C1-C3 alkyl, (CH2)l-NR2R3, or(CH2)m-C(O)-NR2R3, wherein l and m independently of each other represent 0, 1 or 2, with the proviso that when B in Q1 represents oxygen atom, then P is absent;and R2and R3 independently represent C1 or C2 alkyl, or R2 and R3 together with nitrogen atom to which they are both attached form a 6- membered saturated heterocyclicring, wherein one of carbon atoms can be replaced with oxygen, -NH-or N(C1-C2)alkyl-; and acid addition salts thereof. The compound can be useful in the treatment of cancer diseases. (I)</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2014</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20140918&DB=EPODOC&CC=CA&NR=2900629A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20140918&DB=EPODOC&CC=CA&NR=2900629A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>DUBIEL, KRZYSZTOF</creatorcontrib><creatorcontrib>STANCZAK, ALEKSANDRA</creatorcontrib><creatorcontrib>WIECZOREK, MACIEJ</creatorcontrib><creatorcontrib>GRYGIELEWICZ, PAULINA</creatorcontrib><creatorcontrib>LIPNER, JOANNA</creatorcontrib><creatorcontrib>ZDZALIK, DARIA</creatorcontrib><creatorcontrib>DZWONEK, KAROLINA</creatorcontrib><creatorcontrib>YAMANI, ABDELLAH</creatorcontrib><creatorcontrib>LAMPARSKA-PRZYBYSZ, MONIKA</creatorcontrib><title>PYRAZOLYLBENZO[D]IMIDAZOLE DERIVATIVES</title><description>A compound represented by the general Formula (I), whereinhydrogen atoms shown as attached to pyrazole and benzimidazole rings are attached to one of nitrogen atoms of the pyrazole or benzimidazole ring, respectively; R1 represents -X-Q-P, wherein X is absent or represents CH2-, C(O)-, or C(O)NH-(CH2)k-, wherein k is 0, 1 or 2; Q is selected from the group consisting of Q1, Q2, Q3, Q4 and Q5; P is absent or represents straight-or branched-chain C1-C3 alkyl, (CH2)l-NR2R3, or(CH2)m-C(O)-NR2R3, wherein l and m independently of each other represent 0, 1 or 2, with the proviso that when B in Q1 represents oxygen atom, then P is absent;and R2and R3 independently represent C1 or C2 alkyl, or R2 and R3 together with nitrogen atom to which they are both attached form a 6- membered saturated heterocyclicring, wherein one of carbon atoms can be replaced with oxygen, -NH-or N(C1-C2)alkyl-; and acid addition salts thereof. The compound can be useful in the treatment of cancer diseases. (I)</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2014</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFALiAxyjPL3ifRxcvWL8o92ifX09XQBibgquLgGeYY5hniGuQbzMLCmJeYUp_JCaW4GBTfXEGcP3dSC_PjU4oLE5NS81JJ4Z0cjSwMDMyNLR0NjIpQAANgwI98</recordid><startdate>20140918</startdate><enddate>20140918</enddate><creator>DUBIEL, KRZYSZTOF</creator><creator>STANCZAK, ALEKSANDRA</creator><creator>WIECZOREK, MACIEJ</creator><creator>GRYGIELEWICZ, PAULINA</creator><creator>LIPNER, JOANNA</creator><creator>ZDZALIK, DARIA</creator><creator>DZWONEK, KAROLINA</creator><creator>YAMANI, ABDELLAH</creator><creator>LAMPARSKA-PRZYBYSZ, MONIKA</creator><scope>EVB</scope></search><sort><creationdate>20140918</creationdate><title>PYRAZOLYLBENZO[D]IMIDAZOLE DERIVATIVES</title><author>DUBIEL, KRZYSZTOF ; STANCZAK, ALEKSANDRA ; WIECZOREK, MACIEJ ; GRYGIELEWICZ, PAULINA ; LIPNER, JOANNA ; ZDZALIK, DARIA ; DZWONEK, KAROLINA ; YAMANI, ABDELLAH ; LAMPARSKA-PRZYBYSZ, MONIKA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CA2900629A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2014</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>DUBIEL, KRZYSZTOF</creatorcontrib><creatorcontrib>STANCZAK, ALEKSANDRA</creatorcontrib><creatorcontrib>WIECZOREK, MACIEJ</creatorcontrib><creatorcontrib>GRYGIELEWICZ, PAULINA</creatorcontrib><creatorcontrib>LIPNER, JOANNA</creatorcontrib><creatorcontrib>ZDZALIK, DARIA</creatorcontrib><creatorcontrib>DZWONEK, KAROLINA</creatorcontrib><creatorcontrib>YAMANI, ABDELLAH</creatorcontrib><creatorcontrib>LAMPARSKA-PRZYBYSZ, MONIKA</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>DUBIEL, KRZYSZTOF</au><au>STANCZAK, ALEKSANDRA</au><au>WIECZOREK, MACIEJ</au><au>GRYGIELEWICZ, PAULINA</au><au>LIPNER, JOANNA</au><au>ZDZALIK, DARIA</au><au>DZWONEK, KAROLINA</au><au>YAMANI, ABDELLAH</au><au>LAMPARSKA-PRZYBYSZ, MONIKA</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PYRAZOLYLBENZO[D]IMIDAZOLE DERIVATIVES</title><date>2014-09-18</date><risdate>2014</risdate><abstract>A compound represented by the general Formula (I), whereinhydrogen atoms shown as attached to pyrazole and benzimidazole rings are attached to one of nitrogen atoms of the pyrazole or benzimidazole ring, respectively; R1 represents -X-Q-P, wherein X is absent or represents CH2-, C(O)-, or C(O)NH-(CH2)k-, wherein k is 0, 1 or 2; Q is selected from the group consisting of Q1, Q2, Q3, Q4 and Q5; P is absent or represents straight-or branched-chain C1-C3 alkyl, (CH2)l-NR2R3, or(CH2)m-C(O)-NR2R3, wherein l and m independently of each other represent 0, 1 or 2, with the proviso that when B in Q1 represents oxygen atom, then P is absent;and R2and R3 independently represent C1 or C2 alkyl, or R2 and R3 together with nitrogen atom to which they are both attached form a 6- membered saturated heterocyclicring, wherein one of carbon atoms can be replaced with oxygen, -NH-or N(C1-C2)alkyl-; and acid addition salts thereof. The compound can be useful in the treatment of cancer diseases. (I)</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | PYRAZOLYLBENZO[D]IMIDAZOLE DERIVATIVES |
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