CHROMATOGRAPHIC PURIFICATION OF POLYUNSATURATED FATTY ACIDS

The present invention provides a chromatographic separation process for recovering a polyunsaturated fatty acid (PUFA) product from a feed mixture, which comprises: (a) purifying the feed mixture in a first chromatographic separation step using as eluent a mixture of water and a first organic solven...

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Hauptverfasser:	KELLIHER, ADAM, MORRISON, ANGUS
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ANIMAL AND VEGETABLE OILS, FATS, FATTY SUBSTANCES AND WAXES CANDLES CHEMISTRY DETERGENTS EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKINGOILS ESSENTIAL OILS FATS, OILS OR FATTY ACIDS BY CHEMICAL MODIFICATION OF FATS,OILS, OR FATTY ACIDS OBTAINED THEREFROM FATTY ACIDS FROM FATS, OILS OR WAXES FATTY ACIDS THEREFROM FOODS OR FOODSTUFFS HUMAN NECESSITIES METALLURGY PERFORMING OPERATIONS PERFUMES PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL PRODUCING (PRESSING, EXTRACTION), REFINING AND PRESERVINGFATS, FATTY SUBSTANCES (e.g. LANOLIN), FATTY OILS AND WAXES,INCLUDING EXTRACTION FROM WASTE MATERIALS SEPARATION THEIR TREATMENT, NOT COVERED BY OTHER CLASSES TRANSPORTING
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creator	KELLIHER, ADAM MORRISON, ANGUS
description	The present invention provides a chromatographic separation process for recovering a polyunsaturated fatty acid (PUFA) product from a feed mixture, which comprises: (a) purifying the feed mixture in a first chromatographic separation step using as eluent a mixture of water and a first organic solvent, to obtain an intermediate product; and (b) purifying the intermediate product in a second chromatographic separation step using as eluent a mixture of water and a second organic solvent, to obtain the PUFA product, wherein the second organic solvent is different from the first organic solvent and has a polarity index which differs from the polarity index of the first organic solvent by between 0.1 and 2.0, wherein the PUFA product is other than alpha-linolenic acid (ALA), gamma-linolenic acid (GLA), linoleic acid, an ALA mono- di- or triglyceride, a GLA mono- di- or triglyceride, a linoleic acid mono, di- or triglyceride, an ALA C1 -C4 alkyl ester, a GLA C1 -C4 alkyl ester or a linoleic acid C1 -C4 or a mixture thereof. Cette invention concerne un procédé de séparation chromatographique qui permet de récupérer un produit d'acide gras polyinsaturé (PUFA) à partir d'un mélange d'alimentation, ledit procédé comprenant : (a) la purification du mélange d'alimentation dans une première étape de séparation chromatographique utilisant à titre d'éluant un mélange d'eau et d'un premier solvant organique, pour obtenir un produit intermédiaire; et (b) la purification du produit intermédiaire dans une seconde étape de séparation chromatographique utilisant à titre d'éluant un mélange d'eau et d'un second solvant organique, pour obtenir le produit PUFA. Le second solvant organique est différent du premier et a un indice de polarité qui diffère de celui du premier solvant organique d'une valeur comprise entre 0,1 et 2,0, le produit PUFA étant autre qu'un acide alpha-linolénique (ALA), un acide gamma-linolénique (GLA), un acide linoléique, un mono-, un di- ou un triglycéride ALA, un mono-, un di- ou un triglycéride GLA, un mono-, un di- ou un triglycéride d'acide linoléique, un ester d'alkyle C1-C4 ALA, un ester d'alkyle C1-C4 GLA ou un ester d'alkyle C1-C4 d'acide linoléique ou un mélange de ceux-ci.
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Cette invention concerne un procédé de séparation chromatographique qui permet de récupérer un produit d'acide gras polyinsaturé (PUFA) à partir d'un mélange d'alimentation, ledit procédé comprenant : (a) la purification du mélange d'alimentation dans une première étape de séparation chromatographique utilisant à titre d'éluant un mélange d'eau et d'un premier solvant organique, pour obtenir un produit intermédiaire; et (b) la purification du produit intermédiaire dans une seconde étape de séparation chromatographique utilisant à titre d'éluant un mélange d'eau et d'un second solvant organique, pour obtenir le produit PUFA. Le second solvant organique est différent du premier et a un indice de polarité qui diffère de celui du premier solvant organique d'une valeur comprise entre 0,1 et 2,0, le produit PUFA étant autre qu'un acide alpha-linolénique (ALA), un acide gamma-linolénique (GLA), un acide linoléique, un mono-, un di- ou un triglycéride ALA, un mono-, un di- ou un triglycéride GLA, un mono-, un di- ou un triglycéride d'acide linoléique, un ester d'alkyle C1-C4 ALA, un ester d'alkyle C1-C4 GLA ou un ester d'alkyle C1-C4 d'acide linoléique ou un mélange de ceux-ci.</description><language>eng ; fre</language><subject>ANIMAL AND VEGETABLE OILS, FATS, FATTY SUBSTANCES AND WAXES ; CANDLES ; CHEMISTRY ; DETERGENTS ; EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKINGOILS ; ESSENTIAL OILS ; FATS, OILS OR FATTY ACIDS BY CHEMICAL MODIFICATION OF FATS,OILS, OR FATTY ACIDS OBTAINED THEREFROM ; FATTY ACIDS FROM FATS, OILS OR WAXES ; FATTY ACIDS THEREFROM ; FOODS OR FOODSTUFFS ; HUMAN NECESSITIES ; METALLURGY ; PERFORMING OPERATIONS ; PERFUMES ; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL ; PRODUCING (PRESSING, EXTRACTION), REFINING AND PRESERVINGFATS, FATTY SUBSTANCES (e.g. LANOLIN), FATTY OILS AND WAXES,INCLUDING EXTRACTION FROM WASTE MATERIALS ; SEPARATION ; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES ; TRANSPORTING</subject><creationdate>2019</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20191029&DB=EPODOC&CC=CA&NR=2896743C$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20191029&DB=EPODOC&CC=CA&NR=2896743C$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>KELLIHER, ADAM</creatorcontrib><creatorcontrib>MORRISON, ANGUS</creatorcontrib><title>CHROMATOGRAPHIC PURIFICATION OF POLYUNSATURATED FATTY ACIDS</title><description>The present invention provides a chromatographic separation process for recovering a polyunsaturated fatty acid (PUFA) product from a feed mixture, which comprises: (a) purifying the feed mixture in a first chromatographic separation step using as eluent a mixture of water and a first organic solvent, to obtain an intermediate product; and (b) purifying the intermediate product in a second chromatographic separation step using as eluent a mixture of water and a second organic solvent, to obtain the PUFA product, wherein the second organic solvent is different from the first organic solvent and has a polarity index which differs from the polarity index of the first organic solvent by between 0.1 and 2.0, wherein the PUFA product is other than alpha-linolenic acid (ALA), gamma-linolenic acid (GLA), linoleic acid, an ALA mono- di- or triglyceride, a GLA mono- di- or triglyceride, a linoleic acid mono, di- or triglyceride, an ALA C1 -C4 alkyl ester, a GLA C1 -C4 alkyl ester or a linoleic acid C1 -C4 or a mixture thereof. Cette invention concerne un procédé de séparation chromatographique qui permet de récupérer un produit d'acide gras polyinsaturé (PUFA) à partir d'un mélange d'alimentation, ledit procédé comprenant : (a) la purification du mélange d'alimentation dans une première étape de séparation chromatographique utilisant à titre d'éluant un mélange d'eau et d'un premier solvant organique, pour obtenir un produit intermédiaire; et (b) la purification du produit intermédiaire dans une seconde étape de séparation chromatographique utilisant à titre d'éluant un mélange d'eau et d'un second solvant organique, pour obtenir le produit PUFA. Le second solvant organique est différent du premier et a un indice de polarité qui diffère de celui du premier solvant organique d'une valeur comprise entre 0,1 et 2,0, le produit PUFA étant autre qu'un acide alpha-linolénique (ALA), un acide gamma-linolénique (GLA), un acide linoléique, un mono-, un di- ou un triglycéride ALA, un mono-, un di- ou un triglycéride GLA, un mono-, un di- ou un triglycéride d'acide linoléique, un ester d'alkyle C1-C4 ALA, un ester d'alkyle C1-C4 GLA ou un ester d'alkyle C1-C4 d'acide linoléique ou un mélange de ceux-ci.</description><subject>ANIMAL AND VEGETABLE OILS, FATS, FATTY SUBSTANCES AND WAXES</subject><subject>CANDLES</subject><subject>CHEMISTRY</subject><subject>DETERGENTS</subject><subject>EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKINGOILS</subject><subject>ESSENTIAL OILS</subject><subject>FATS, OILS OR FATTY ACIDS BY CHEMICAL MODIFICATION OF FATS,OILS, OR FATTY ACIDS OBTAINED THEREFROM</subject><subject>FATTY ACIDS FROM FATS, OILS OR WAXES</subject><subject>FATTY ACIDS THEREFROM</subject><subject>FOODS OR FOODSTUFFS</subject><subject>HUMAN NECESSITIES</subject><subject>METALLURGY</subject><subject>PERFORMING OPERATIONS</subject><subject>PERFUMES</subject><subject>PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL</subject><subject>PRODUCING (PRESSING, EXTRACTION), REFINING AND PRESERVINGFATS, FATTY SUBSTANCES (e.g. LANOLIN), FATTY OILS AND WAXES,INCLUDING EXTRACTION FROM WASTE MATERIALS</subject><subject>SEPARATION</subject><subject>THEIR TREATMENT, NOT COVERED BY OTHER CLASSES</subject><subject>TRANSPORTING</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2019</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLB29gjy93UM8XcPcgzw8HRWCAgN8nTzdHYM8fT3U_B3Uwjw94kM9Qt2DAkNcgxxdVFwcwwJiVRwdPZ0CeZhYE1LzClO5YXS3Azybq4hzh66qQX58anFBYnJqXmpJfHOjkYWlmbmJsbOxoRVAAB3xCjz</recordid><startdate>20191029</startdate><enddate>20191029</enddate><creator>KELLIHER, ADAM</creator><creator>MORRISON, ANGUS</creator><scope>EVB</scope></search><sort><creationdate>20191029</creationdate><title>CHROMATOGRAPHIC PURIFICATION OF POLYUNSATURATED FATTY ACIDS</title><author>KELLIHER, ADAM ; MORRISON, ANGUS</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CA2896743C3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2019</creationdate><topic>ANIMAL AND VEGETABLE OILS, FATS, FATTY SUBSTANCES AND WAXES</topic><topic>CANDLES</topic><topic>CHEMISTRY</topic><topic>DETERGENTS</topic><topic>EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKINGOILS</topic><topic>ESSENTIAL OILS</topic><topic>FATS, OILS OR FATTY ACIDS BY CHEMICAL MODIFICATION OF FATS,OILS, OR FATTY ACIDS OBTAINED THEREFROM</topic><topic>FATTY ACIDS FROM FATS, OILS OR WAXES</topic><topic>FATTY ACIDS THEREFROM</topic><topic>FOODS OR FOODSTUFFS</topic><topic>HUMAN NECESSITIES</topic><topic>METALLURGY</topic><topic>PERFORMING OPERATIONS</topic><topic>PERFUMES</topic><topic>PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL</topic><topic>PRODUCING (PRESSING, EXTRACTION), REFINING AND PRESERVINGFATS, FATTY SUBSTANCES (e.g. LANOLIN), FATTY OILS AND WAXES,INCLUDING EXTRACTION FROM WASTE MATERIALS</topic><topic>SEPARATION</topic><topic>THEIR TREATMENT, NOT COVERED BY OTHER CLASSES</topic><topic>TRANSPORTING</topic><toplevel>online_resources</toplevel><creatorcontrib>KELLIHER, ADAM</creatorcontrib><creatorcontrib>MORRISON, ANGUS</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>KELLIHER, ADAM</au><au>MORRISON, ANGUS</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>CHROMATOGRAPHIC PURIFICATION OF POLYUNSATURATED FATTY ACIDS</title><date>2019-10-29</date><risdate>2019</risdate><abstract>The present invention provides a chromatographic separation process for recovering a polyunsaturated fatty acid (PUFA) product from a feed mixture, which comprises: (a) purifying the feed mixture in a first chromatographic separation step using as eluent a mixture of water and a first organic solvent, to obtain an intermediate product; and (b) purifying the intermediate product in a second chromatographic separation step using as eluent a mixture of water and a second organic solvent, to obtain the PUFA product, wherein the second organic solvent is different from the first organic solvent and has a polarity index which differs from the polarity index of the first organic solvent by between 0.1 and 2.0, wherein the PUFA product is other than alpha-linolenic acid (ALA), gamma-linolenic acid (GLA), linoleic acid, an ALA mono- di- or triglyceride, a GLA mono- di- or triglyceride, a linoleic acid mono, di- or triglyceride, an ALA C1 -C4 alkyl ester, a GLA C1 -C4 alkyl ester or a linoleic acid C1 -C4 or a mixture thereof. Cette invention concerne un procédé de séparation chromatographique qui permet de récupérer un produit d'acide gras polyinsaturé (PUFA) à partir d'un mélange d'alimentation, ledit procédé comprenant : (a) la purification du mélange d'alimentation dans une première étape de séparation chromatographique utilisant à titre d'éluant un mélange d'eau et d'un premier solvant organique, pour obtenir un produit intermédiaire; et (b) la purification du produit intermédiaire dans une seconde étape de séparation chromatographique utilisant à titre d'éluant un mélange d'eau et d'un second solvant organique, pour obtenir le produit PUFA. Le second solvant organique est différent du premier et a un indice de polarité qui diffère de celui du premier solvant organique d'une valeur comprise entre 0,1 et 2,0, le produit PUFA étant autre qu'un acide alpha-linolénique (ALA), un acide gamma-linolénique (GLA), un acide linoléique, un mono-, un di- ou un triglycéride ALA, un mono-, un di- ou un triglycéride GLA, un mono-, un di- ou un triglycéride d'acide linoléique, un ester d'alkyle C1-C4 ALA, un ester d'alkyle C1-C4 GLA ou un ester d'alkyle C1-C4 d'acide linoléique ou un mélange de ceux-ci.</abstract><oa>free_for_read</oa></addata></record>
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subjects	ANIMAL AND VEGETABLE OILS, FATS, FATTY SUBSTANCES AND WAXES CANDLES CHEMISTRY DETERGENTS EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKINGOILS ESSENTIAL OILS FATS, OILS OR FATTY ACIDS BY CHEMICAL MODIFICATION OF FATS,OILS, OR FATTY ACIDS OBTAINED THEREFROM FATTY ACIDS FROM FATS, OILS OR WAXES FATTY ACIDS THEREFROM FOODS OR FOODSTUFFS HUMAN NECESSITIES METALLURGY PERFORMING OPERATIONS PERFUMES PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL PRODUCING (PRESSING, EXTRACTION), REFINING AND PRESERVINGFATS, FATTY SUBSTANCES (e.g. LANOLIN), FATTY OILS AND WAXES,INCLUDING EXTRACTION FROM WASTE MATERIALS SEPARATION THEIR TREATMENT, NOT COVERED BY OTHER CLASSES TRANSPORTING
title	CHROMATOGRAPHIC PURIFICATION OF POLYUNSATURATED FATTY ACIDS
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