MODIFIED AXL PEPTIDES AND THEIR USE IN INHIBITION OF AXL SIGNALING IN ANTI-METASTATIC THERAPY
Compositions and methods are provided for alleviating cancer in a mammal by administering a therapeutic dose of a pharmaceutical composition that inhibits activity of AXL, MER or Tyro3 protein activity, for example by competitive or non-competitive inhibition of the binding interaction between AXL,...
Gespeichert in:
| Hauptverfasser: | , , , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng ; fre |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | FUH, KATHERINE RANKIN, ERINN BRUNO MIAO, YU KARIOLIS, MIHALIS GIACCIA, AMATO J JONES, DOUGLAS HERSHENSON, SUSAN COCHRAN, JENNIFER R |
| description | Compositions and methods are provided for alleviating cancer in a mammal by administering a therapeutic dose of a pharmaceutical composition that inhibits activity of AXL, MER or Tyro3 protein activity, for example by competitive or non-competitive inhibition of the binding interaction between AXL, MER or Tyro3 and its ligand GAS6.
L'invention concerne des compositions et des procédés qui permettent d'atténuer un cancer, chez un mammifère, par l'administration d'une dose thérapeutique d'une composition pharmaceutique qui inhibe l'activité d'AXL, de MER ou de l'activité de la protéine Tyro3, par exemple par l'inhibition compétitive ou non compétitive de l'interaction de liaison entre AXL, MER ou Tyro3 et son ligand GAS6. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_CA2894539C</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>CA2894539C</sourcerecordid><originalsourceid>FETCH-epo_espacenet_CA2894539C3</originalsourceid><addsrcrecordid>eNqFi0EKwjAQRbtxIeoZnAt0YxXsckwmzUCbhGYEXUgpEleihXp_tOJe-PAW7_15dmm8ZsOkAU81BArCmiKg0yCWuIVjJGD3meUDC3sH3nzbyJXDml01aXTCeUOCUVBYTd8Ww3mZzW79fUyrHxfZ2pAom6fh2aVx6K_pkV6dws2-3O6KUhX_izfqajFw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>MODIFIED AXL PEPTIDES AND THEIR USE IN INHIBITION OF AXL SIGNALING IN ANTI-METASTATIC THERAPY</title><source>esp@cenet</source><creator>FUH, KATHERINE ; RANKIN, ERINN BRUNO ; MIAO, YU ; KARIOLIS, MIHALIS ; GIACCIA, AMATO J ; JONES, DOUGLAS ; HERSHENSON, SUSAN ; COCHRAN, JENNIFER R</creator><creatorcontrib>FUH, KATHERINE ; RANKIN, ERINN BRUNO ; MIAO, YU ; KARIOLIS, MIHALIS ; GIACCIA, AMATO J ; JONES, DOUGLAS ; HERSHENSON, SUSAN ; COCHRAN, JENNIFER R</creatorcontrib><description>Compositions and methods are provided for alleviating cancer in a mammal by administering a therapeutic dose of a pharmaceutical composition that inhibits activity of AXL, MER or Tyro3 protein activity, for example by competitive or non-competitive inhibition of the binding interaction between AXL, MER or Tyro3 and its ligand GAS6.
L'invention concerne des compositions et des procédés qui permettent d'atténuer un cancer, chez un mammifère, par l'administration d'une dose thérapeutique d'une composition pharmaceutique qui inhibe l'activité d'AXL, de MER ou de l'activité de la protéine Tyro3, par exemple par l'inhibition compétitive ou non compétitive de l'interaction de liaison entre AXL, MER ou Tyro3 et son ligand GAS6.</description><language>eng ; fre</language><subject>CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2021</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210928&DB=EPODOC&CC=CA&NR=2894539C$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210928&DB=EPODOC&CC=CA&NR=2894539C$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>FUH, KATHERINE</creatorcontrib><creatorcontrib>RANKIN, ERINN BRUNO</creatorcontrib><creatorcontrib>MIAO, YU</creatorcontrib><creatorcontrib>KARIOLIS, MIHALIS</creatorcontrib><creatorcontrib>GIACCIA, AMATO J</creatorcontrib><creatorcontrib>JONES, DOUGLAS</creatorcontrib><creatorcontrib>HERSHENSON, SUSAN</creatorcontrib><creatorcontrib>COCHRAN, JENNIFER R</creatorcontrib><title>MODIFIED AXL PEPTIDES AND THEIR USE IN INHIBITION OF AXL SIGNALING IN ANTI-METASTATIC THERAPY</title><description>Compositions and methods are provided for alleviating cancer in a mammal by administering a therapeutic dose of a pharmaceutical composition that inhibits activity of AXL, MER or Tyro3 protein activity, for example by competitive or non-competitive inhibition of the binding interaction between AXL, MER or Tyro3 and its ligand GAS6.
L'invention concerne des compositions et des procédés qui permettent d'atténuer un cancer, chez un mammifère, par l'administration d'une dose thérapeutique d'une composition pharmaceutique qui inhibe l'activité d'AXL, de MER ou de l'activité de la protéine Tyro3, par exemple par l'inhibition compétitive ou non compétitive de l'interaction de liaison entre AXL, MER ou Tyro3 et son ligand GAS6.</description><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2021</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqFi0EKwjAQRbtxIeoZnAt0YxXsckwmzUCbhGYEXUgpEleihXp_tOJe-PAW7_15dmm8ZsOkAU81BArCmiKg0yCWuIVjJGD3meUDC3sH3nzbyJXDml01aXTCeUOCUVBYTd8Ww3mZzW79fUyrHxfZ2pAom6fh2aVx6K_pkV6dws2-3O6KUhX_izfqajFw</recordid><startdate>20210928</startdate><enddate>20210928</enddate><creator>FUH, KATHERINE</creator><creator>RANKIN, ERINN BRUNO</creator><creator>MIAO, YU</creator><creator>KARIOLIS, MIHALIS</creator><creator>GIACCIA, AMATO J</creator><creator>JONES, DOUGLAS</creator><creator>HERSHENSON, SUSAN</creator><creator>COCHRAN, JENNIFER R</creator><scope>EVB</scope></search><sort><creationdate>20210928</creationdate><title>MODIFIED AXL PEPTIDES AND THEIR USE IN INHIBITION OF AXL SIGNALING IN ANTI-METASTATIC THERAPY</title><author>FUH, KATHERINE ; RANKIN, ERINN BRUNO ; MIAO, YU ; KARIOLIS, MIHALIS ; GIACCIA, AMATO J ; JONES, DOUGLAS ; HERSHENSON, SUSAN ; COCHRAN, JENNIFER R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CA2894539C3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2021</creationdate><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>FUH, KATHERINE</creatorcontrib><creatorcontrib>RANKIN, ERINN BRUNO</creatorcontrib><creatorcontrib>MIAO, YU</creatorcontrib><creatorcontrib>KARIOLIS, MIHALIS</creatorcontrib><creatorcontrib>GIACCIA, AMATO J</creatorcontrib><creatorcontrib>JONES, DOUGLAS</creatorcontrib><creatorcontrib>HERSHENSON, SUSAN</creatorcontrib><creatorcontrib>COCHRAN, JENNIFER R</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>FUH, KATHERINE</au><au>RANKIN, ERINN BRUNO</au><au>MIAO, YU</au><au>KARIOLIS, MIHALIS</au><au>GIACCIA, AMATO J</au><au>JONES, DOUGLAS</au><au>HERSHENSON, SUSAN</au><au>COCHRAN, JENNIFER R</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>MODIFIED AXL PEPTIDES AND THEIR USE IN INHIBITION OF AXL SIGNALING IN ANTI-METASTATIC THERAPY</title><date>2021-09-28</date><risdate>2021</risdate><abstract>Compositions and methods are provided for alleviating cancer in a mammal by administering a therapeutic dose of a pharmaceutical composition that inhibits activity of AXL, MER or Tyro3 protein activity, for example by competitive or non-competitive inhibition of the binding interaction between AXL, MER or Tyro3 and its ligand GAS6.
L'invention concerne des compositions et des procédés qui permettent d'atténuer un cancer, chez un mammifère, par l'administration d'une dose thérapeutique d'une composition pharmaceutique qui inhibe l'activité d'AXL, de MER ou de l'activité de la protéine Tyro3, par exemple par l'inhibition compétitive ou non compétitive de l'interaction de liaison entre AXL, MER ou Tyro3 et son ligand GAS6.</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng ; fre |
| recordid | cdi_epo_espacenet_CA2894539C |
| source | esp@cenet |
| subjects | CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | MODIFIED AXL PEPTIDES AND THEIR USE IN INHIBITION OF AXL SIGNALING IN ANTI-METASTATIC THERAPY |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T01%3A25%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=FUH,%20KATHERINE&rft.date=2021-09-28&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3ECA2894539C%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |