FIBRONECTIN BASED SCAFFOLD DOMAIN PROTEINS THAT BIND TO MYOSTATIN

The present invention relates to fibronectin-based scaffold domain proteins that bind to myostatin. The invention also relates to the use of these proteins in therapeutic applications to treat muscular dystrophy, cachexia, sarcopenia, osteoarthritis, osteoporosis, diabetes, obesity, COPD, chronic ki...

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Hauptverfasser:	ENGLE, LINDA, YAMNIUK, AARON P, MADIREDDI, MALAVI, CLOAD, SHARON, KOZHICH, ALEXANDER T, KRYSTEK, STANLEY RICHARD, LIPOVSEK, DASA, WEI, HUI, ZHAO, WENJUN, SWAIN, JOANNA, CORBETT, MARTIN J, RAMAMURTHY, VIDHYASHANKAR, RAKESTRAW, GINGER CHAO
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY METALLURGY ORGANIC CHEMISTRY PEPTIDES
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creator	ENGLE, LINDA YAMNIUK, AARON P MADIREDDI, MALAVI CLOAD, SHARON KOZHICH, ALEXANDER T KRYSTEK, STANLEY RICHARD LIPOVSEK, DASA WEI, HUI ZHAO, WENJUN SWAIN, JOANNA CORBETT, MARTIN J RAMAMURTHY, VIDHYASHANKAR RAKESTRAW, GINGER CHAO
description	The present invention relates to fibronectin-based scaffold domain proteins that bind to myostatin. The invention also relates to the use of these proteins in therapeutic applications to treat muscular dystrophy, cachexia, sarcopenia, osteoarthritis, osteoporosis, diabetes, obesity, COPD, chronic kidney disease, heart failure, myocardial infarction, and fibrosis. The invention further relates to cells comprising such proteins, polynucleotides encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the proteins. La présente invention concerne des protéines à domaine d'échafaudage à base de fibronectine qui se lient à la myostatine. L'invention concerne également l'utilisation de ces protéines dans des applications thérapeutiques pour traiter la dystrophie musculaire, la cachexie, la sarcopénie, l'arthrose, l'ostéoporose, le diabète, l'obésité, COPD, une néphropathie chronique, l'insuffisance cardiaque, un infarctus du myocarde et une fibrose. L'invention concerne en outre des cellules comportant de telles protéines, des polynucléotides codant pour de telles protéines ou leurs fragments, et des vecteurs comportant les polynucléotides codant pour les protéines.
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The invention also relates to the use of these proteins in therapeutic applications to treat muscular dystrophy, cachexia, sarcopenia, osteoarthritis, osteoporosis, diabetes, obesity, COPD, chronic kidney disease, heart failure, myocardial infarction, and fibrosis. The invention further relates to cells comprising such proteins, polynucleotides encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the proteins. La présente invention concerne des protéines à domaine d'échafaudage à base de fibronectine qui se lient à la myostatine. L'invention concerne également l'utilisation de ces protéines dans des applications thérapeutiques pour traiter la dystrophie musculaire, la cachexie, la sarcopénie, l'arthrose, l'ostéoporose, le diabète, l'obésité, COPD, une néphropathie chronique, l'insuffisance cardiaque, un infarctus du myocarde et une fibrose. L'invention concerne en outre des cellules comportant de telles protéines, des polynucléotides codant pour de telles protéines ou leurs fragments, et des vecteurs comportant les polynucléotides codant pour les protéines.</abstract><oa>free_for_read</oa></addata></record>
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subjects	CHEMISTRY METALLURGY ORGANIC CHEMISTRY PEPTIDES
title	FIBRONECTIN BASED SCAFFOLD DOMAIN PROTEINS THAT BIND TO MYOSTATIN
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