CYCLIC ETHER PYRAZOL-4-YL-HETEROCYCLYL-CARBOXAMIDE COMPOUNDS AND METHODS OF USE
Cyclic ether pyrazol-4-yl-heterocyclyl-carboxamide compounds of Formula I, including stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof, wherein R2 is a cyclic ether and X is thiazolyl, pyrazinyl, pyridinyl, or pyrimidinyl, are useful for inhibiting Pim kinase...
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| creator | HODGES, ALASTAIR JAMES SUN, MINGHUA SHARPE, ANDREW BLACKABY, WESLEY BURCH, JASON WANG, XIAOJING |
| description | Cyclic ether pyrazol-4-yl-heterocyclyl-carboxamide compounds of Formula I, including stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof, wherein R2 is a cyclic ether and X is thiazolyl, pyrazinyl, pyridinyl, or pyrimidinyl, are useful for inhibiting Pim kinase, and for treating disorders such as cancer mediated by Pim kinase. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
L'invention concerne des composés d'éther cyclique-pyrazol-4-yl-hétérocyclyl-carboxamide de formule I, y compris les stéréo-isomères, les isomères géométriques, les tautomères et leurs sels pharmaceutiquement acceptables, R2 représentant un éther cyclique et X représentant thiazolyle, pyrazinyle, pyridinyle ou pyrimidinyle, utiles pour l'inhibition de la kinase Pim et pour le traitement de troubles tels que le cancer médié par la kinase Pim. L'invention concerne des procédés d'utilisation des composés de formule I pour le diagnostic in vitro, in situ et in vivo, la prévention ou le traitement de tels troubles dans des cellules mammifères ou d'états pathologiques associés. |
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L'invention concerne des composés d'éther cyclique-pyrazol-4-yl-hétérocyclyl-carboxamide de formule I, y compris les stéréo-isomères, les isomères géométriques, les tautomères et leurs sels pharmaceutiquement acceptables, R2 représentant un éther cyclique et X représentant thiazolyle, pyrazinyle, pyridinyle ou pyrimidinyle, utiles pour l'inhibition de la kinase Pim et pour le traitement de troubles tels que le cancer médié par la kinase Pim. L'invention concerne des procédés d'utilisation des composés de formule I pour le diagnostic in vitro, in situ et in vivo, la prévention ou le traitement de tels troubles dans des cellules mammifères ou d'états pathologiques associés.</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2021</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210608&DB=EPODOC&CC=CA&NR=2881068C$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210608&DB=EPODOC&CC=CA&NR=2881068C$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>HODGES, ALASTAIR JAMES</creatorcontrib><creatorcontrib>SUN, MINGHUA</creatorcontrib><creatorcontrib>SHARPE, ANDREW</creatorcontrib><creatorcontrib>BLACKABY, WESLEY</creatorcontrib><creatorcontrib>BURCH, JASON</creatorcontrib><creatorcontrib>WANG, XIAOJING</creatorcontrib><title>CYCLIC ETHER PYRAZOL-4-YL-HETEROCYCLYL-CARBOXAMIDE COMPOUNDS AND METHODS OF USE</title><description>Cyclic ether pyrazol-4-yl-heterocyclyl-carboxamide compounds of Formula I, including stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof, wherein R2 is a cyclic ether and X is thiazolyl, pyrazinyl, pyridinyl, or pyrimidinyl, are useful for inhibiting Pim kinase, and for treating disorders such as cancer mediated by Pim kinase. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
L'invention concerne des composés d'éther cyclique-pyrazol-4-yl-hétérocyclyl-carboxamide de formule I, y compris les stéréo-isomères, les isomères géométriques, les tautomères et leurs sels pharmaceutiquement acceptables, R2 représentant un éther cyclique et X représentant thiazolyle, pyrazinyle, pyridinyle ou pyrimidinyle, utiles pour l'inhibition de la kinase Pim et pour le traitement de troubles tels que le cancer médié par la kinase Pim. L'invention concerne des procédés d'utilisation des composés de formule I pour le diagnostic in vitro, in situ et in vivo, la prévention ou le traitement de tels troubles dans des cellules mammifères ou d'états pathologiques associés.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2021</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZPB3jnT28XRWcA3xcA1SCIgMcozy99E10Y300fVwDXENAssDOc6OQU7-EY6-ni6uCs7-vgH-oX4uwQqOfi4KvkCt_kC2v5tCaLArDwNrWmJOcSovlOZmkHdzDXH20E0tyI9PLS5ITE7NSy2Jd3Y0srAwNDCzcDYmrAIAnw4uAg</recordid><startdate>20210608</startdate><enddate>20210608</enddate><creator>HODGES, ALASTAIR JAMES</creator><creator>SUN, MINGHUA</creator><creator>SHARPE, ANDREW</creator><creator>BLACKABY, WESLEY</creator><creator>BURCH, JASON</creator><creator>WANG, XIAOJING</creator><scope>EVB</scope></search><sort><creationdate>20210608</creationdate><title>CYCLIC ETHER PYRAZOL-4-YL-HETEROCYCLYL-CARBOXAMIDE COMPOUNDS AND METHODS OF USE</title><author>HODGES, ALASTAIR JAMES ; SUN, MINGHUA ; SHARPE, ANDREW ; BLACKABY, WESLEY ; BURCH, JASON ; WANG, XIAOJING</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CA2881068C3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2021</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>HODGES, ALASTAIR JAMES</creatorcontrib><creatorcontrib>SUN, MINGHUA</creatorcontrib><creatorcontrib>SHARPE, ANDREW</creatorcontrib><creatorcontrib>BLACKABY, WESLEY</creatorcontrib><creatorcontrib>BURCH, JASON</creatorcontrib><creatorcontrib>WANG, XIAOJING</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>HODGES, ALASTAIR JAMES</au><au>SUN, MINGHUA</au><au>SHARPE, ANDREW</au><au>BLACKABY, WESLEY</au><au>BURCH, JASON</au><au>WANG, XIAOJING</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>CYCLIC ETHER PYRAZOL-4-YL-HETEROCYCLYL-CARBOXAMIDE COMPOUNDS AND METHODS OF USE</title><date>2021-06-08</date><risdate>2021</risdate><abstract>Cyclic ether pyrazol-4-yl-heterocyclyl-carboxamide compounds of Formula I, including stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof, wherein R2 is a cyclic ether and X is thiazolyl, pyrazinyl, pyridinyl, or pyrimidinyl, are useful for inhibiting Pim kinase, and for treating disorders such as cancer mediated by Pim kinase. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
L'invention concerne des composés d'éther cyclique-pyrazol-4-yl-hétérocyclyl-carboxamide de formule I, y compris les stéréo-isomères, les isomères géométriques, les tautomères et leurs sels pharmaceutiquement acceptables, R2 représentant un éther cyclique et X représentant thiazolyle, pyrazinyle, pyridinyle ou pyrimidinyle, utiles pour l'inhibition de la kinase Pim et pour le traitement de troubles tels que le cancer médié par la kinase Pim. L'invention concerne des procédés d'utilisation des composés de formule I pour le diagnostic in vitro, in situ et in vivo, la prévention ou le traitement de tels troubles dans des cellules mammifères ou d'états pathologiques associés.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | CYCLIC ETHER PYRAZOL-4-YL-HETEROCYCLYL-CARBOXAMIDE COMPOUNDS AND METHODS OF USE |
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