PIPERAZINOTRIAZOLE COMPOUND, PREPARATION METHOD THEREOF, AND USE THEREOF IN DRUG PREPARATION
Provided is a piperazinotrizole compound represented by general formula I or an isomer, a pharmaceutically acceptable salt, ester, prodrug or hydrate thereof. Also provided are a method for preparing the compound, a drug composition containing the compound, and a use thereof as a high-selectivity po...
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| creator | MIAO, ZEHONG ZHANG, AO CHEN, CHUANHUIZI HUAN, XIAJUAN SONG, ZILAN DING, JIAN CHEN, YI YE, NA |
| description | Provided is a piperazinotrizole compound represented by general formula I or an isomer, a pharmaceutically acceptable salt, ester, prodrug or hydrate thereof. Also provided are a method for preparing the compound, a drug composition containing the compound, and a use thereof as a high-selectivity poly(ADP-ribose) polymerase-1 (PARP1) inhibitor in the preparation of drugs for the prevention and/or treatment of PARP-related diseases.
L'invention concerne un composé de pipérazinotrizole représenté par la formule générale I ou un isomère, un sel, un ester, un promédicament ou un hydrate pharmaceutiquement acceptable de celui-ci. L'invention concerne aussi un procédé de préparation du composé, une composition de médicament contenant le composé, et une utilisation de celui-ci en tant qu'inhibiteur de poly(ADP-ribose) polymérase-1 (PARP1) de sélectivité élevée dans la préparation de médicaments pour la prévention et/ou le traitement de maladies liées à la PARP. |
| format | Patent |
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L'invention concerne un composé de pipérazinotrizole représenté par la formule générale I ou un isomère, un sel, un ester, un promédicament ou un hydrate pharmaceutiquement acceptable de celui-ci. L'invention concerne aussi un procédé de préparation du composé, une composition de médicament contenant le composé, et une utilisation de celui-ci en tant qu'inhibiteur de poly(ADP-ribose) polymérase-1 (PARP1) de sélectivité élevée dans la préparation de médicaments pour la prévention et/ou le traitement de maladies liées à la PARP.</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2017</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20170530&DB=EPODOC&CC=CA&NR=2880739C$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25545,76296</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20170530&DB=EPODOC&CC=CA&NR=2880739C$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>MIAO, ZEHONG</creatorcontrib><creatorcontrib>ZHANG, AO</creatorcontrib><creatorcontrib>CHEN, CHUANHUIZI</creatorcontrib><creatorcontrib>HUAN, XIAJUAN</creatorcontrib><creatorcontrib>SONG, ZILAN</creatorcontrib><creatorcontrib>DING, JIAN</creatorcontrib><creatorcontrib>CHEN, YI</creatorcontrib><creatorcontrib>YE, NA</creatorcontrib><title>PIPERAZINOTRIAZOLE COMPOUND, PREPARATION METHOD THEREOF, AND USE THEREOF IN DRUG PREPARATION</title><description>Provided is a piperazinotrizole compound represented by general formula I or an isomer, a pharmaceutically acceptable salt, ester, prodrug or hydrate thereof. Also provided are a method for preparing the compound, a drug composition containing the compound, and a use thereof as a high-selectivity poly(ADP-ribose) polymerase-1 (PARP1) inhibitor in the preparation of drugs for the prevention and/or treatment of PARP-related diseases.
L'invention concerne un composé de pipérazinotrizole représenté par la formule générale I ou un isomère, un sel, un ester, un promédicament ou un hydrate pharmaceutiquement acceptable de celui-ci. L'invention concerne aussi un procédé de préparation du composé, une composition de médicament contenant le composé, et une utilisation de celui-ci en tant qu'inhibiteur de poly(ADP-ribose) polymérase-1 (PARP1) de sélectivité élevée dans la préparation de médicaments pour la prévention et/ou le traitement de maladies liées à la PARP.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2017</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZIgJ8AxwDXKM8vTzDwnydIzy93FVcPb3DfAP9XPRUQgIcg1wDHIM8fT3U_B1DfHwd1EI8XANcvV301Fw9HNRCA12hQkoePopuASFuiPr4WFgTUvMKU7lhdLcDPJuriHOHrqpBfnxqcUFicmpeakl8c6ORhYWBubGls7GhFUAACmUMck</recordid><startdate>20170530</startdate><enddate>20170530</enddate><creator>MIAO, ZEHONG</creator><creator>ZHANG, AO</creator><creator>CHEN, CHUANHUIZI</creator><creator>HUAN, XIAJUAN</creator><creator>SONG, ZILAN</creator><creator>DING, JIAN</creator><creator>CHEN, YI</creator><creator>YE, NA</creator><scope>EVB</scope></search><sort><creationdate>20170530</creationdate><title>PIPERAZINOTRIAZOLE COMPOUND, PREPARATION METHOD THEREOF, AND USE THEREOF IN DRUG PREPARATION</title><author>MIAO, ZEHONG ; ZHANG, AO ; CHEN, CHUANHUIZI ; HUAN, XIAJUAN ; SONG, ZILAN ; DING, JIAN ; CHEN, YI ; YE, NA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CA2880739C3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2017</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>MIAO, ZEHONG</creatorcontrib><creatorcontrib>ZHANG, AO</creatorcontrib><creatorcontrib>CHEN, CHUANHUIZI</creatorcontrib><creatorcontrib>HUAN, XIAJUAN</creatorcontrib><creatorcontrib>SONG, ZILAN</creatorcontrib><creatorcontrib>DING, JIAN</creatorcontrib><creatorcontrib>CHEN, YI</creatorcontrib><creatorcontrib>YE, NA</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>MIAO, ZEHONG</au><au>ZHANG, AO</au><au>CHEN, CHUANHUIZI</au><au>HUAN, XIAJUAN</au><au>SONG, ZILAN</au><au>DING, JIAN</au><au>CHEN, YI</au><au>YE, NA</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PIPERAZINOTRIAZOLE COMPOUND, PREPARATION METHOD THEREOF, AND USE THEREOF IN DRUG PREPARATION</title><date>2017-05-30</date><risdate>2017</risdate><abstract>Provided is a piperazinotrizole compound represented by general formula I or an isomer, a pharmaceutically acceptable salt, ester, prodrug or hydrate thereof. Also provided are a method for preparing the compound, a drug composition containing the compound, and a use thereof as a high-selectivity poly(ADP-ribose) polymerase-1 (PARP1) inhibitor in the preparation of drugs for the prevention and/or treatment of PARP-related diseases.
L'invention concerne un composé de pipérazinotrizole représenté par la formule générale I ou un isomère, un sel, un ester, un promédicament ou un hydrate pharmaceutiquement acceptable de celui-ci. L'invention concerne aussi un procédé de préparation du composé, une composition de médicament contenant le composé, et une utilisation de celui-ci en tant qu'inhibiteur de poly(ADP-ribose) polymérase-1 (PARP1) de sélectivité élevée dans la préparation de médicaments pour la prévention et/ou le traitement de maladies liées à la PARP.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | PIPERAZINOTRIAZOLE COMPOUND, PREPARATION METHOD THEREOF, AND USE THEREOF IN DRUG PREPARATION |
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