EXTENDED RELEASE, ABUSE DETERRENT PHARMACEUTICAL COMPOSITIONS
The present disclosure provides pharmaceutical compositions comprising at least one active pharmaceutical ingredient or a pharmaceutically acceptable salt thereof, at least one hydrophilic plastomer, optionally at least one hydrophilic elastomer, and at least one deliquescent plasticizer, wherein th...
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| creator | CASTANEDA, CARLOS H PARK, JAE HAN GOWER, BRAD L HERMAN, CLIFFORD J |
| description | The present disclosure provides pharmaceutical compositions comprising at least one active pharmaceutical ingredient or a pharmaceutically acceptable salt thereof, at least one hydrophilic plastomer, optionally at least one hydrophilic elastomer, and at least one deliquescent plasticizer, wherein the pharmaceutical compositions provide extended release of the API and have abuse deterrent properties. Also provided are methods for preparing the pharmaceutical compositions in which the components of the composition are humidified such that the deliquescent plasticizer deliquesces, thereby plasticizing the hydrophilic polymers.
La présente invention concerne des compositions pharmaceutiques comportant au moins un principe actif pharmaceutique ou un sel pharmaceutiquement acceptable de celui-ci, au moins un plastomère hydrophile, éventuellement au moins un élastomère hydrophile, et au moins un plastifiant déliquescent, les compositions pharmaceutiques fournissant une libération prolongée du principe actif pharmaceutique et possédant des propriétés de dissuasion d'abus. L'invention concerne également des procédés pour la préparation des compositions pharmaceutiques dans lesquelles les composants de la composition sont humidifiés de sorte que le plastifiant déliquescent se dissolve, permettant ainsi la plastification des polymères hydrophiles. |
| format | Patent |
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La présente invention concerne des compositions pharmaceutiques comportant au moins un principe actif pharmaceutique ou un sel pharmaceutiquement acceptable de celui-ci, au moins un plastomère hydrophile, éventuellement au moins un élastomère hydrophile, et au moins un plastifiant déliquescent, les compositions pharmaceutiques fournissant une libération prolongée du principe actif pharmaceutique et possédant des propriétés de dissuasion d'abus. L'invention concerne également des procédés pour la préparation des compositions pharmaceutiques dans lesquelles les composants de la composition sont humidifiés de sorte que le plastifiant déliquescent se dissolve, permettant ainsi la plastification des polymères hydrophiles.</description><language>eng ; fre</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2017</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20170718&DB=EPODOC&CC=CA&NR=2877774C$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20170718&DB=EPODOC&CC=CA&NR=2877774C$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>CASTANEDA, CARLOS H</creatorcontrib><creatorcontrib>PARK, JAE HAN</creatorcontrib><creatorcontrib>GOWER, BRAD L</creatorcontrib><creatorcontrib>HERMAN, CLIFFORD J</creatorcontrib><title>EXTENDED RELEASE, ABUSE DETERRENT PHARMACEUTICAL COMPOSITIONS</title><description>The present disclosure provides pharmaceutical compositions comprising at least one active pharmaceutical ingredient or a pharmaceutically acceptable salt thereof, at least one hydrophilic plastomer, optionally at least one hydrophilic elastomer, and at least one deliquescent plasticizer, wherein the pharmaceutical compositions provide extended release of the API and have abuse deterrent properties. Also provided are methods for preparing the pharmaceutical compositions in which the components of the composition are humidified such that the deliquescent plasticizer deliquesces, thereby plasticizing the hydrophilic polymers.
La présente invention concerne des compositions pharmaceutiques comportant au moins un principe actif pharmaceutique ou un sel pharmaceutiquement acceptable de celui-ci, au moins un plastomère hydrophile, éventuellement au moins un élastomère hydrophile, et au moins un plastifiant déliquescent, les compositions pharmaceutiques fournissant une libération prolongée du principe actif pharmaceutique et possédant des propriétés de dissuasion d'abus. L'invention concerne également des procédés pour la préparation des compositions pharmaceutiques dans lesquelles les composants de la composition sont humidifiés de sorte que le plastifiant déliquescent se dissolve, permettant ainsi la plastification des polymères hydrophiles.</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2017</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLB1jQhx9XNxdVEIcvVxdQx21VFwdAoNdlVwcQ1xDQpy9QtRCPBwDPJ1dHYNDfF0dvRRcPb3DfAP9gzx9PcL5mFgTUvMKU7lhdLcDPJuriHOHrqpBfnxqcUFicmpeakl8c6ORhbmQGDibExYBQCdailD</recordid><startdate>20170718</startdate><enddate>20170718</enddate><creator>CASTANEDA, CARLOS H</creator><creator>PARK, JAE HAN</creator><creator>GOWER, BRAD L</creator><creator>HERMAN, CLIFFORD J</creator><scope>EVB</scope></search><sort><creationdate>20170718</creationdate><title>EXTENDED RELEASE, ABUSE DETERRENT PHARMACEUTICAL COMPOSITIONS</title><author>CASTANEDA, CARLOS H ; PARK, JAE HAN ; GOWER, BRAD L ; HERMAN, CLIFFORD J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CA2877774C3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2017</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>CASTANEDA, CARLOS H</creatorcontrib><creatorcontrib>PARK, JAE HAN</creatorcontrib><creatorcontrib>GOWER, BRAD L</creatorcontrib><creatorcontrib>HERMAN, CLIFFORD J</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>CASTANEDA, CARLOS H</au><au>PARK, JAE HAN</au><au>GOWER, BRAD L</au><au>HERMAN, CLIFFORD J</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>EXTENDED RELEASE, ABUSE DETERRENT PHARMACEUTICAL COMPOSITIONS</title><date>2017-07-18</date><risdate>2017</risdate><abstract>The present disclosure provides pharmaceutical compositions comprising at least one active pharmaceutical ingredient or a pharmaceutically acceptable salt thereof, at least one hydrophilic plastomer, optionally at least one hydrophilic elastomer, and at least one deliquescent plasticizer, wherein the pharmaceutical compositions provide extended release of the API and have abuse deterrent properties. Also provided are methods for preparing the pharmaceutical compositions in which the components of the composition are humidified such that the deliquescent plasticizer deliquesces, thereby plasticizing the hydrophilic polymers.
La présente invention concerne des compositions pharmaceutiques comportant au moins un principe actif pharmaceutique ou un sel pharmaceutiquement acceptable de celui-ci, au moins un plastomère hydrophile, éventuellement au moins un élastomère hydrophile, et au moins un plastifiant déliquescent, les compositions pharmaceutiques fournissant une libération prolongée du principe actif pharmaceutique et possédant des propriétés de dissuasion d'abus. L'invention concerne également des procédés pour la préparation des compositions pharmaceutiques dans lesquelles les composants de la composition sont humidifiés de sorte que le plastifiant déliquescent se dissolve, permettant ainsi la plastification des polymères hydrophiles.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | EXTENDED RELEASE, ABUSE DETERRENT PHARMACEUTICAL COMPOSITIONS |
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