IMPROVED ANTAGONIST ANTIBODIES AGAINST GDF-8 AND USES THEREFOR
The disclosure provides improved neutralizing anti-GDF-8 antibodies capable of substantially higher levels of expression in host cells compared to previous anti-GDF-8 antibodies. Also provided are methods of using compositions comprising such antibodies to increase muscle mass or strength, and to tr...
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Format: | Patent |
| Sprache: | eng ; fre |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | MADER, MICHELLE MARIE PARRIS, KEVIN DELOS APGAR, JAMES REASONER |
| description | The disclosure provides improved neutralizing anti-GDF-8 antibodies capable of substantially higher levels of expression in host cells compared to previous anti-GDF-8 antibodies. Also provided are methods of using compositions comprising such antibodies to increase muscle mass or strength, and to treat or prevent muscular disorders, neuromuscular disorders, metabolic disorders, adipose tissue disorders or bone disorders.
La présente invention concerne de meilleurs anticorps neutralisants anti-GDF-8 aptes à présenter des niveaux d'expression sensiblement plus élevés dans les cellules hôtes comparativement aux anticorps anti-GDF-8 précédents. La présente invention concerne également des procédés permettant d'utiliser des compositions contenant de tels anticorps pour augmenter la masse ou la force musculaire, et pour traiter ou prévenir des troubles musculaires, des troubles neuromusculaires, des troubles du métabolisme, des troubles des tissus adipeux ou des troubles osseux. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_CA2876397C</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>CA2876397C</sourcerecordid><originalsourceid>FETCH-epo_espacenet_CA2876397C3</originalsourceid><addsrcrecordid>eNrjZLDz9A0I8g9zdVFw9AtxdPf38wwOATE9nfxdPF2DFRzdHT39gELuLm66FkAJF4XQYKBwiIdrkKubfxAPA2taYk5xKi-U5maQd3MNcfbQTS3Ij08tLkhMTs1LLYl3djSyMDcztjR3NiasAgCtYSku</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>IMPROVED ANTAGONIST ANTIBODIES AGAINST GDF-8 AND USES THEREFOR</title><source>esp@cenet</source><creator>MADER, MICHELLE MARIE ; PARRIS, KEVIN DELOS ; APGAR, JAMES REASONER</creator><creatorcontrib>MADER, MICHELLE MARIE ; PARRIS, KEVIN DELOS ; APGAR, JAMES REASONER</creatorcontrib><description>The disclosure provides improved neutralizing anti-GDF-8 antibodies capable of substantially higher levels of expression in host cells compared to previous anti-GDF-8 antibodies. Also provided are methods of using compositions comprising such antibodies to increase muscle mass or strength, and to treat or prevent muscular disorders, neuromuscular disorders, metabolic disorders, adipose tissue disorders or bone disorders.
La présente invention concerne de meilleurs anticorps neutralisants anti-GDF-8 aptes à présenter des niveaux d'expression sensiblement plus élevés dans les cellules hôtes comparativement aux anticorps anti-GDF-8 précédents. La présente invention concerne également des procédés permettant d'utiliser des compositions contenant de tels anticorps pour augmenter la masse ou la force musculaire, et pour traiter ou prévenir des troubles musculaires, des troubles neuromusculaires, des troubles du métabolisme, des troubles des tissus adipeux ou des troubles osseux.</description><language>eng ; fre</language><subject>CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2019</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190806&DB=EPODOC&CC=CA&NR=2876397C$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76318</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190806&DB=EPODOC&CC=CA&NR=2876397C$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>MADER, MICHELLE MARIE</creatorcontrib><creatorcontrib>PARRIS, KEVIN DELOS</creatorcontrib><creatorcontrib>APGAR, JAMES REASONER</creatorcontrib><title>IMPROVED ANTAGONIST ANTIBODIES AGAINST GDF-8 AND USES THEREFOR</title><description>The disclosure provides improved neutralizing anti-GDF-8 antibodies capable of substantially higher levels of expression in host cells compared to previous anti-GDF-8 antibodies. Also provided are methods of using compositions comprising such antibodies to increase muscle mass or strength, and to treat or prevent muscular disorders, neuromuscular disorders, metabolic disorders, adipose tissue disorders or bone disorders.
La présente invention concerne de meilleurs anticorps neutralisants anti-GDF-8 aptes à présenter des niveaux d'expression sensiblement plus élevés dans les cellules hôtes comparativement aux anticorps anti-GDF-8 précédents. La présente invention concerne également des procédés permettant d'utiliser des compositions contenant de tels anticorps pour augmenter la masse ou la force musculaire, et pour traiter ou prévenir des troubles musculaires, des troubles neuromusculaires, des troubles du métabolisme, des troubles des tissus adipeux ou des troubles osseux.</description><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2019</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLDz9A0I8g9zdVFw9AtxdPf38wwOATE9nfxdPF2DFRzdHT39gELuLm66FkAJF4XQYKBwiIdrkKubfxAPA2taYk5xKi-U5maQd3MNcfbQTS3Ij08tLkhMTs1LLYl3djSyMDcztjR3NiasAgCtYSku</recordid><startdate>20190806</startdate><enddate>20190806</enddate><creator>MADER, MICHELLE MARIE</creator><creator>PARRIS, KEVIN DELOS</creator><creator>APGAR, JAMES REASONER</creator><scope>EVB</scope></search><sort><creationdate>20190806</creationdate><title>IMPROVED ANTAGONIST ANTIBODIES AGAINST GDF-8 AND USES THEREFOR</title><author>MADER, MICHELLE MARIE ; PARRIS, KEVIN DELOS ; APGAR, JAMES REASONER</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CA2876397C3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2019</creationdate><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>MADER, MICHELLE MARIE</creatorcontrib><creatorcontrib>PARRIS, KEVIN DELOS</creatorcontrib><creatorcontrib>APGAR, JAMES REASONER</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>MADER, MICHELLE MARIE</au><au>PARRIS, KEVIN DELOS</au><au>APGAR, JAMES REASONER</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>IMPROVED ANTAGONIST ANTIBODIES AGAINST GDF-8 AND USES THEREFOR</title><date>2019-08-06</date><risdate>2019</risdate><abstract>The disclosure provides improved neutralizing anti-GDF-8 antibodies capable of substantially higher levels of expression in host cells compared to previous anti-GDF-8 antibodies. Also provided are methods of using compositions comprising such antibodies to increase muscle mass or strength, and to treat or prevent muscular disorders, neuromuscular disorders, metabolic disorders, adipose tissue disorders or bone disorders.
La présente invention concerne de meilleurs anticorps neutralisants anti-GDF-8 aptes à présenter des niveaux d'expression sensiblement plus élevés dans les cellules hôtes comparativement aux anticorps anti-GDF-8 précédents. La présente invention concerne également des procédés permettant d'utiliser des compositions contenant de tels anticorps pour augmenter la masse ou la force musculaire, et pour traiter ou prévenir des troubles musculaires, des troubles neuromusculaires, des troubles du métabolisme, des troubles des tissus adipeux ou des troubles osseux.</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng ; fre |
| recordid | cdi_epo_espacenet_CA2876397C |
| source | esp@cenet |
| subjects | CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | IMPROVED ANTAGONIST ANTIBODIES AGAINST GDF-8 AND USES THEREFOR |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-10T10%3A08%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=MADER,%20MICHELLE%20MARIE&rft.date=2019-08-06&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3ECA2876397C%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |