IMPROVED ANTAGONIST ANTIBODIES AGAINST GDF-8 AND USES THEREFOR

IMPROVED ANTAGONIST ANTIBODIES AGAINST GDF-8 AND USES THEREFOR

The disclosure provides improved neutralizing anti-GDF-8 antibodies capable of substantially higher levels of expression in host cells compared to previous anti-GDF-8 antibodies. Also provided are methods of using compositions comprising such antibodies to increase muscle mass or strength, and to tr...

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Hauptverfasser: MADER, MICHELLE MARIE, PARRIS, KEVIN DELOS, APGAR, JAMES REASONER
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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creator MADER, MICHELLE MARIE
PARRIS, KEVIN DELOS
APGAR, JAMES REASONER
description The disclosure provides improved neutralizing anti-GDF-8 antibodies capable of substantially higher levels of expression in host cells compared to previous anti-GDF-8 antibodies. Also provided are methods of using compositions comprising such antibodies to increase muscle mass or strength, and to treat or prevent muscular disorders, neuromuscular disorders, metabolic disorders, adipose tissue disorders or bone disorders.
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subjects CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title IMPROVED ANTAGONIST ANTIBODIES AGAINST GDF-8 AND USES THEREFOR
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