COATED MEDICAL DEVICES COMPRISING A WATER-INSOLUBLE THERAPEUTIC AGENT AND AN ADDITIVE
A medical device includes an implantable structure and a coating layer including a water-insoluble therapeutic agent and one or more additives selected from heparin, heparan sulfate, dextran and dextran sulfate, and physiologically- acceptable salts thereof. The one or more additives can be present...
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| creator | SHIRLEY, GARY B SARASAM, APARNA R GRABLE, CHARITY BARBICK, JULIA E BARNETT, ANGELA R |
| description | A medical device includes an implantable structure and a coating layer including a water-insoluble therapeutic agent and one or more additives selected from heparin, heparan sulfate, dextran and dextran sulfate, and physiologically- acceptable salts thereof. The one or more additives can be present in an amount effective to increase the rate of release of the water-insoluble therapeutic agent from the coating layer. The implantable medical device structure can be an expandable structure such as a balloon or stent. Also described are methods of making and using such implantable medical devices and coating layers.
La présente invention concerne un dispositif médical comportant une structure implantable et une couche de revêtement comprenant un agent thérapeutique non hydrosoluble et un ou des additif(s) choisi(s) parmi l'héparine, le sulfate d'héparane, le dextrane et le sulfate de dextrane, et leurs sels physiologiquement acceptables. L'un ou les additif(s) peut/peuvent être présent(s) en une quantité efficace pour accroître le taux de libération de l'agent thérapeutique non hydrosoluble depuis la couche de revêtement. La structure de dispositif médical implantable peut être une structure expansible telle d'un ballonnet ou une endoprothèse. L'invention concerne également des procédés de fabrication et d'utilisation de tels dispositifs médicaux et couches de revêtement implantables. |
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La présente invention concerne un dispositif médical comportant une structure implantable et une couche de revêtement comprenant un agent thérapeutique non hydrosoluble et un ou des additif(s) choisi(s) parmi l'héparine, le sulfate d'héparane, le dextrane et le sulfate de dextrane, et leurs sels physiologiquement acceptables. L'un ou les additif(s) peut/peuvent être présent(s) en une quantité efficace pour accroître le taux de libération de l'agent thérapeutique non hydrosoluble depuis la couche de revêtement. La structure de dispositif médical implantable peut être une structure expansible telle d'un ballonnet ou une endoprothèse. L'invention concerne également des procédés de fabrication et d'utilisation de tels dispositifs médicaux et couches de revêtement implantables.</description><language>eng ; fre</language><subject>BANDAGES, DRESSINGS OR ABSORBENT PADS ; DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY ; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR ; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROMTHE BODY ; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF,TUBULAR STRUCTURES OF THE BODY, E.G. STENTS ; FILTERS IMPLANTABLE INTO BLOOD VESSELS ; FIRST-AID KITS ; FOMENTATION ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROSTHESES ; TREATMENT OR PROTECTION OF EYES OR EARS</subject><creationdate>2017</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20171205&DB=EPODOC&CC=CA&NR=2872464C$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20171205&DB=EPODOC&CC=CA&NR=2872464C$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SHIRLEY, GARY B</creatorcontrib><creatorcontrib>SARASAM, APARNA R</creatorcontrib><creatorcontrib>GRABLE, CHARITY</creatorcontrib><creatorcontrib>BARBICK, JULIA E</creatorcontrib><creatorcontrib>BARNETT, ANGELA R</creatorcontrib><title>COATED MEDICAL DEVICES COMPRISING A WATER-INSOLUBLE THERAPEUTIC AGENT AND AN ADDITIVE</title><description>A medical device includes an implantable structure and a coating layer including a water-insoluble therapeutic agent and one or more additives selected from heparin, heparan sulfate, dextran and dextran sulfate, and physiologically- acceptable salts thereof. The one or more additives can be present in an amount effective to increase the rate of release of the water-insoluble therapeutic agent from the coating layer. The implantable medical device structure can be an expandable structure such as a balloon or stent. Also described are methods of making and using such implantable medical devices and coating layers.
La présente invention concerne un dispositif médical comportant une structure implantable et une couche de revêtement comprenant un agent thérapeutique non hydrosoluble et un ou des additif(s) choisi(s) parmi l'héparine, le sulfate d'héparane, le dextrane et le sulfate de dextrane, et leurs sels physiologiquement acceptables. L'un ou les additif(s) peut/peuvent être présent(s) en une quantité efficace pour accroître le taux de libération de l'agent thérapeutique non hydrosoluble depuis la couche de revêtement. La structure de dispositif médical implantable peut être une structure expansible telle d'un ballonnet ou une endoprothèse. L'invention concerne également des procédés de fabrication et d'utilisation de tels dispositifs médicaux et couches de revêtement implantables.</description><subject>BANDAGES, DRESSINGS OR ABSORBENT PADS</subject><subject>DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY</subject><subject>DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR</subject><subject>DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROMTHE BODY</subject><subject>DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF,TUBULAR STRUCTURES OF THE BODY, E.G. STENTS</subject><subject>FILTERS IMPLANTABLE INTO BLOOD VESSELS</subject><subject>FIRST-AID KITS</subject><subject>FOMENTATION</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROSTHESES</subject><subject>TREATMENT OR PROTECTION OF EYES OR EARS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2017</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqFyj0KwkAQQOFtLEQ9g3OBNDGo7Tg7JgOb3bA_sQxB1ko0EO-PKewtHq_51iqRw8gaWtZCaEBzL8QByLWdlyC2BoTbQnwhNjiTLoYhNuyx4xSFAGu2EdDqJUCtJUrPW7V6jM85737fqP2VIzVFnt5Dnqfxnl_5MxCW51NZHSs6_BdfeeYvOA</recordid><startdate>20171205</startdate><enddate>20171205</enddate><creator>SHIRLEY, GARY B</creator><creator>SARASAM, APARNA R</creator><creator>GRABLE, CHARITY</creator><creator>BARBICK, JULIA E</creator><creator>BARNETT, ANGELA R</creator><scope>EVB</scope></search><sort><creationdate>20171205</creationdate><title>COATED MEDICAL DEVICES COMPRISING A WATER-INSOLUBLE THERAPEUTIC AGENT AND AN ADDITIVE</title><author>SHIRLEY, GARY B ; SARASAM, APARNA R ; GRABLE, CHARITY ; BARBICK, JULIA E ; BARNETT, ANGELA R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CA2872464C3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2017</creationdate><topic>BANDAGES, DRESSINGS OR ABSORBENT PADS</topic><topic>DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY</topic><topic>DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR</topic><topic>DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROMTHE BODY</topic><topic>DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF,TUBULAR STRUCTURES OF THE BODY, E.G. STENTS</topic><topic>FILTERS IMPLANTABLE INTO BLOOD VESSELS</topic><topic>FIRST-AID KITS</topic><topic>FOMENTATION</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROSTHESES</topic><topic>TREATMENT OR PROTECTION OF EYES OR EARS</topic><toplevel>online_resources</toplevel><creatorcontrib>SHIRLEY, GARY B</creatorcontrib><creatorcontrib>SARASAM, APARNA R</creatorcontrib><creatorcontrib>GRABLE, CHARITY</creatorcontrib><creatorcontrib>BARBICK, JULIA E</creatorcontrib><creatorcontrib>BARNETT, ANGELA R</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>SHIRLEY, GARY B</au><au>SARASAM, APARNA R</au><au>GRABLE, CHARITY</au><au>BARBICK, JULIA E</au><au>BARNETT, ANGELA R</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>COATED MEDICAL DEVICES COMPRISING A WATER-INSOLUBLE THERAPEUTIC AGENT AND AN ADDITIVE</title><date>2017-12-05</date><risdate>2017</risdate><abstract>A medical device includes an implantable structure and a coating layer including a water-insoluble therapeutic agent and one or more additives selected from heparin, heparan sulfate, dextran and dextran sulfate, and physiologically- acceptable salts thereof. The one or more additives can be present in an amount effective to increase the rate of release of the water-insoluble therapeutic agent from the coating layer. The implantable medical device structure can be an expandable structure such as a balloon or stent. Also described are methods of making and using such implantable medical devices and coating layers.
La présente invention concerne un dispositif médical comportant une structure implantable et une couche de revêtement comprenant un agent thérapeutique non hydrosoluble et un ou des additif(s) choisi(s) parmi l'héparine, le sulfate d'héparane, le dextrane et le sulfate de dextrane, et leurs sels physiologiquement acceptables. L'un ou les additif(s) peut/peuvent être présent(s) en une quantité efficace pour accroître le taux de libération de l'agent thérapeutique non hydrosoluble depuis la couche de revêtement. La structure de dispositif médical implantable peut être une structure expansible telle d'un ballonnet ou une endoprothèse. L'invention concerne également des procédés de fabrication et d'utilisation de tels dispositifs médicaux et couches de revêtement implantables.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BANDAGES, DRESSINGS OR ABSORBENT PADS DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROMTHE BODY DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF,TUBULAR STRUCTURES OF THE BODY, E.G. STENTS FILTERS IMPLANTABLE INTO BLOOD VESSELS FIRST-AID KITS FOMENTATION HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROSTHESES TREATMENT OR PROTECTION OF EYES OR EARS |
| title | COATED MEDICAL DEVICES COMPRISING A WATER-INSOLUBLE THERAPEUTIC AGENT AND AN ADDITIVE |
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