VACCINES AND METHODS TO TREAT LYME DISEASE IN DOGS

The instant invention provides an immunogenic composition comprising an antigenic fragment of OspA protein of Borrelia burgdorferi and a chimeric protein containing antigenic fragments of different phylotypes of OspC protein of Borrelia burgdorferi. Vaccines incorporating the immunogenic composition...

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Bibliographische Detailangaben
Hauptverfasser:	XU, ZACH, EARNHART, CHRISTOPHER, MEEUS, PATRICK F. M, MILLERSHIP, JASON J, LOHSE, ROBERT M, MARCONI, RICHARD THOMAS
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The instant invention provides an immunogenic composition comprising an antigenic fragment of OspA protein of Borrelia burgdorferi and a chimeric protein containing antigenic fragments of different phylotypes of OspC protein of Borrelia burgdorferi. Vaccines incorporating the immunogenic composition of the invention, as well as methods of preventing Lyme disease in dogs and/or protecting dogs from Lyme disease using the vaccines are also provided. La présente invention concerne une composition immunogène comprenant un fragment antigénique de la protéine OspA de Borrelia burgdorferi et une protéine chimère contenant des fragments antigéniques de différents phylotypes de la protéine OspC de Borrelia burgdorferi. La présente invention concerne en outre des vaccins incorporant la composition immunogène de l'invention, ainsi que des procédés de prévention de la maladie de Lyme chez les chiens et/ou de protection des chiens contre la maladie de Lyme à l'aide des vaccins.