5-[3-(2,5-DICHLORO-4,6-DIMETHYL-1-OXY-PYRIDIN-3-YL)-[1,2,4]OXADIAZOL-5-YL]-2-HYDROXY-3-METHOXY-1-NITROBENZENE AS AN INTERMEDIATE TO PREPARE A CATECHOL-O-METHYLTRANSFERASE INHIBITOR

5-[3-(2,5-DICHLORO-4,6-DIMETHYL-1-OXY-PYRIDIN-3-YL)-[1,2,4]OXADIAZOL-5-YL]-2-HYDROXY-3-METHOXY-1-NITROBENZENE AS AN INTERMEDIATE TO PREPARE A CATECHOL-O-METHYLTRANSFERASE INHIBITOR

There is disclosed a methylated intermediate which may be demethylated to provide an inhibitor of catechol-O-methyltransferase useful in the treatment of Parkinson's disease. Also disclosed are methods of making and using said intermediate. (see formula I) L'invention concerne un intermédi...

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Bibliographische Detailangaben
Hauptverfasser: LEARMONTH, DAVID ALEXANDER, REITER, KLAUS, SCHLUMMER, BJOERN, ZIMMERMANN, AXEL, KISS, LASZLO ERNO, RUSSO, DOMENICO, WAHNON, JORGE BRUNO REIS, ESZENYI, TIBOR, KREIS, MICHAEL
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:There is disclosed a methylated intermediate which may be demethylated to provide an inhibitor of catechol-O-methyltransferase useful in the treatment of Parkinson's disease. Also disclosed are methods of making and using said intermediate. (see formula I) L'invention concerne un intermédiaire méthylé qui peut être déméthylé pour fournir un inhibiteur de la catéchol-O-méthyltransférase utile dans le traitement de la maladie de Parkinson. L'invention concerne également des procédés de fabrication et d'utilisation dudit intermédiaire.