CLOSED-CIRCUIT DEVICE AND METHODS FOR ISOLATION, MODIFICATION, AND RE-ADMINISTRATION OF SPECIFIC CONSTITUENTS FROM A BIOLOGICAL FLUID SOURCE
The present invention relates to a method and apparatus for the isolation, modification and re- administration of a molecule (or biomolecule, or class of biomolecules) from the body fluid of a mammal via a closed circuit device. The device contains a series of chambers and connecting lines and valve...
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| description | The present invention relates to a method and apparatus for the isolation, modification and re- administration of a molecule (or biomolecule, or class of biomolecules) from the body fluid of a mammal via a closed circuit device. The device contains a series of chambers and connecting lines and valves, and also may contain a separation unit similar to an apheresis device. The device is able to modify the molecule by the attachment of a secondary molecule, by cross- linking the captured molecule, or by altering the structure of the molecule. The methods and apparatus can be used to return the modified molecule to the mammalian subject for the patient-specific diagnosis and/or treatment of a disease state. The methods and apparatus may also be employed as a closed system for the purification and/or modification of a target molecule from a fluid source such as a perfusion bioreactor.
La présente invention concerne un procédé et un appareil pour lisolement, la modification et la réadministration dune molécule (ou dune biomolécule, ou dune classe de biomolécules) à partir du fluide corporel dun mammifère par lintermédiaire dun dispositif à circuit fermé. Le dispositif contient une série de chambres et de lignes de raccordement et de vannes, et peut également contenir une unité de séparation semblable à un dispositif daphérèse. Le dispositif est capable de modifier la molécule par la fixation dune molécule secondaire, par réticulation de la molécule capturée, ou par modification de la structure de la molécule. Les procédés et lappareil peuvent être utilisés pour renvoyer la molécule modifiée au sujet mammifère pour le diagnostic et/ou le traitement spécifique au patient dun état pathologique. Les procédés et lappareil peuvent également être utilisés en tant que système fermé pour la purification et/ou la modification dune molécule cible à partir dune source de fluide telle quun bioréacteur à perfusion. |
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La présente invention concerne un procédé et un appareil pour lisolement, la modification et la réadministration dune molécule (ou dune biomolécule, ou dune classe de biomolécules) à partir du fluide corporel dun mammifère par lintermédiaire dun dispositif à circuit fermé. Le dispositif contient une série de chambres et de lignes de raccordement et de vannes, et peut également contenir une unité de séparation semblable à un dispositif daphérèse. Le dispositif est capable de modifier la molécule par la fixation dune molécule secondaire, par réticulation de la molécule capturée, ou par modification de la structure de la molécule. Les procédés et lappareil peuvent être utilisés pour renvoyer la molécule modifiée au sujet mammifère pour le diagnostic et/ou le traitement spécifique au patient dun état pathologique. Les procédés et lappareil peuvent également être utilisés en tant que système fermé pour la purification et/ou la modification dune molécule cible à partir dune source de fluide telle quun bioréacteur à perfusion.</description><language>eng ; fre</language><subject>APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY ; BEER ; BIOCHEMISTRY ; CHEMISTRY ; DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY ; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR ; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROMTHE BODY ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; MEASURING ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MUTATION OR GENETIC ENGINEERING ; PHYSICS ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPIRITS ; TESTING ; VINEGAR ; WINE</subject><creationdate>2020</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200324&DB=EPODOC&CC=CA&NR=2827426C$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200324&DB=EPODOC&CC=CA&NR=2827426C$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>MCNEIL, GARY L</creatorcontrib><title>CLOSED-CIRCUIT DEVICE AND METHODS FOR ISOLATION, MODIFICATION, AND RE-ADMINISTRATION OF SPECIFIC CONSTITUENTS FROM A BIOLOGICAL FLUID SOURCE</title><description>The present invention relates to a method and apparatus for the isolation, modification and re- administration of a molecule (or biomolecule, or class of biomolecules) from the body fluid of a mammal via a closed circuit device. The device contains a series of chambers and connecting lines and valves, and also may contain a separation unit similar to an apheresis device. The device is able to modify the molecule by the attachment of a secondary molecule, by cross- linking the captured molecule, or by altering the structure of the molecule. The methods and apparatus can be used to return the modified molecule to the mammalian subject for the patient-specific diagnosis and/or treatment of a disease state. The methods and apparatus may also be employed as a closed system for the purification and/or modification of a target molecule from a fluid source such as a perfusion bioreactor.
La présente invention concerne un procédé et un appareil pour lisolement, la modification et la réadministration dune molécule (ou dune biomolécule, ou dune classe de biomolécules) à partir du fluide corporel dun mammifère par lintermédiaire dun dispositif à circuit fermé. Le dispositif contient une série de chambres et de lignes de raccordement et de vannes, et peut également contenir une unité de séparation semblable à un dispositif daphérèse. Le dispositif est capable de modifier la molécule par la fixation dune molécule secondaire, par réticulation de la molécule capturée, ou par modification de la structure de la molécule. Les procédés et lappareil peuvent être utilisés pour renvoyer la molécule modifiée au sujet mammifère pour le diagnostic et/ou le traitement spécifique au patient dun état pathologique. 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The device contains a series of chambers and connecting lines and valves, and also may contain a separation unit similar to an apheresis device. The device is able to modify the molecule by the attachment of a secondary molecule, by cross- linking the captured molecule, or by altering the structure of the molecule. The methods and apparatus can be used to return the modified molecule to the mammalian subject for the patient-specific diagnosis and/or treatment of a disease state. The methods and apparatus may also be employed as a closed system for the purification and/or modification of a target molecule from a fluid source such as a perfusion bioreactor.
La présente invention concerne un procédé et un appareil pour lisolement, la modification et la réadministration dune molécule (ou dune biomolécule, ou dune classe de biomolécules) à partir du fluide corporel dun mammifère par lintermédiaire dun dispositif à circuit fermé. Le dispositif contient une série de chambres et de lignes de raccordement et de vannes, et peut également contenir une unité de séparation semblable à un dispositif daphérèse. Le dispositif est capable de modifier la molécule par la fixation dune molécule secondaire, par réticulation de la molécule capturée, ou par modification de la structure de la molécule. Les procédés et lappareil peuvent être utilisés pour renvoyer la molécule modifiée au sujet mammifère pour le diagnostic et/ou le traitement spécifique au patient dun état pathologique. Les procédés et lappareil peuvent également être utilisés en tant que système fermé pour la purification et/ou la modification dune molécule cible à partir dune source de fluide telle quun bioréacteur à perfusion.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY BEER BIOCHEMISTRY CHEMISTRY DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROMTHE BODY ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPIRITS TESTING VINEGAR WINE |
| title | CLOSED-CIRCUIT DEVICE AND METHODS FOR ISOLATION, MODIFICATION, AND RE-ADMINISTRATION OF SPECIFIC CONSTITUENTS FROM A BIOLOGICAL FLUID SOURCE |
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