ANTI C-MET ANTIBODIES

The present invention relates to antibodies that specifically bind to the human c-Met receptor protein and that act as strict antagonists of hepatocyte growth factor (HGF)-mediated activation of the c-Met receptor and also inhibit HGF-independent activation of the human c-Met protein. La présente in...

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Bibliographische Detailangaben
Hauptverfasser:	SAUNDERS, MICHAEL, BASILICO, CRISTINA, DE HAARD, JOHANNES, HULTBERG, ANNA, MICHIELI, PAULO, DREIER, TORSTEN, FESTJENS, ELS, DE JONGE, NATALIE
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to antibodies that specifically bind to the human c-Met receptor protein and that act as strict antagonists of hepatocyte growth factor (HGF)-mediated activation of the c-Met receptor and also inhibit HGF-independent activation of the human c-Met protein. La présente invention concerne des anticorps qui se lient spécifiquement à la protéine du récepteur c-Met humain et qui agissent comme antagonistes stricts de l'activation du récepteur c-Met induite par le facteur de croissance hépatocytaire (HGF) et inhibent également l'activation indépendante de HGF de la protéine c-Met humaine.