NICOTINAMIDES AS SYK MODULATORS

The present application is directed to compounds of the following formula and pharmaceutically acceptable salts, esters, and prodrugs thereof which are inhibitors of Syk kinase. Also disclosed are intermediates used in making such compounds, the preparation of such a compound, pharmaceutical composi...

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Hauptverfasser: XU, QING, PANDEY, ANJALI, SONG, YONGHONG, JIA, ZHAOZHONG J, BAUER, SHAWN M, KANE, BRIAN
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creator XU, QING
PANDEY, ANJALI
SONG, YONGHONG
JIA, ZHAOZHONG J
BAUER, SHAWN M
KANE, BRIAN
description The present application is directed to compounds of the following formula and pharmaceutically acceptable salts, esters, and prodrugs thereof which are inhibitors of Syk kinase. Also disclosed are intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition Syk kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by Syk kinase activity, such as Non Hodgkin's Lymphoma. (see above formula) La présente invention concerne des composés de formule I et des sels, esters et promédicaments pharmaceutiquement acceptables de ceux-ci, qui sont des inhibiteurs de la Syk kinase. La présente invention concerne également des intermédiaires utilisés dans la fabrication de tels composés, la préparation d'un tel composé, des compositions pharmaceutiques contenant un tel composé, des procédés d'inhibition de l'activité Syk kinase, des procédés d'inhibition de l'agrégation de plaquettes, et des méthodes de prévention ou de traitement d'un certain nombre d'états pathologiques à médiation au moins en partie par l'activité Syk kinase, tels que le lymphome non hodgkinien.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title NICOTINAMIDES AS SYK MODULATORS
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