NICOTINAMIDES AS SYK MODULATORS
The present application is directed to compounds of the following formula and pharmaceutically acceptable salts, esters, and prodrugs thereof which are inhibitors of Syk kinase. Also disclosed are intermediates used in making such compounds, the preparation of such a compound, pharmaceutical composi...
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creator | XU, QING PANDEY, ANJALI SONG, YONGHONG JIA, ZHAOZHONG J BAUER, SHAWN M KANE, BRIAN |
description | The present application is directed to compounds of the following formula and pharmaceutically acceptable salts, esters, and prodrugs thereof which are inhibitors of Syk kinase. Also disclosed are intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition Syk kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by Syk kinase activity, such as Non Hodgkin's Lymphoma. (see above formula)
La présente invention concerne des composés de formule I et des sels, esters et promédicaments pharmaceutiquement acceptables de ceux-ci, qui sont des inhibiteurs de la Syk kinase. La présente invention concerne également des intermédiaires utilisés dans la fabrication de tels composés, la préparation d'un tel composé, des compositions pharmaceutiques contenant un tel composé, des procédés d'inhibition de l'activité Syk kinase, des procédés d'inhibition de l'agrégation de plaquettes, et des méthodes de prévention ou de traitement d'un certain nombre d'états pathologiques à médiation au moins en partie par l'activité Syk kinase, tels que le lymphome non hodgkinien. |
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La présente invention concerne des composés de formule I et des sels, esters et promédicaments pharmaceutiquement acceptables de ceux-ci, qui sont des inhibiteurs de la Syk kinase. La présente invention concerne également des intermédiaires utilisés dans la fabrication de tels composés, la préparation d'un tel composé, des compositions pharmaceutiques contenant un tel composé, des procédés d'inhibition de l'activité Syk kinase, des procédés d'inhibition de l'agrégation de plaquettes, et des méthodes de prévention ou de traitement d'un certain nombre d'états pathologiques à médiation au moins en partie par l'activité Syk kinase, tels que le lymphome non hodgkinien.</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2019</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20191029&DB=EPODOC&CC=CA&NR=2816219C$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20191029&DB=EPODOC&CC=CA&NR=2816219C$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>XU, QING</creatorcontrib><creatorcontrib>PANDEY, ANJALI</creatorcontrib><creatorcontrib>SONG, YONGHONG</creatorcontrib><creatorcontrib>JIA, ZHAOZHONG J</creatorcontrib><creatorcontrib>BAUER, SHAWN M</creatorcontrib><creatorcontrib>KANE, BRIAN</creatorcontrib><title>NICOTINAMIDES AS SYK MODULATORS</title><description>The present application is directed to compounds of the following formula and pharmaceutically acceptable salts, esters, and prodrugs thereof which are inhibitors of Syk kinase. Also disclosed are intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition Syk kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by Syk kinase activity, such as Non Hodgkin's Lymphoma. (see above formula)
La présente invention concerne des composés de formule I et des sels, esters et promédicaments pharmaceutiquement acceptables de ceux-ci, qui sont des inhibiteurs de la Syk kinase. La présente invention concerne également des intermédiaires utilisés dans la fabrication de tels composés, la préparation d'un tel composé, des compositions pharmaceutiques contenant un tel composé, des procédés d'inhibition de l'activité Syk kinase, des procédés d'inhibition de l'agrégation de plaquettes, et des méthodes de prévention ou de traitement d'un certain nombre d'états pathologiques à médiation au moins en partie par l'activité Syk kinase, tels que le lymphome non hodgkinien.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2019</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZJD383T2D_H0c_T1dHENVnAMVgiO9Fbw9XcJ9XEM8Q8K5mFgTUvMKU7lhdLcDPJuriHOHrqpBfnxqcUFicmpeakl8c6ORhaGZkaGls7GhFUAAF_hIOI</recordid><startdate>20191029</startdate><enddate>20191029</enddate><creator>XU, QING</creator><creator>PANDEY, ANJALI</creator><creator>SONG, YONGHONG</creator><creator>JIA, ZHAOZHONG J</creator><creator>BAUER, SHAWN M</creator><creator>KANE, BRIAN</creator><scope>EVB</scope></search><sort><creationdate>20191029</creationdate><title>NICOTINAMIDES AS SYK MODULATORS</title><author>XU, QING ; PANDEY, ANJALI ; SONG, YONGHONG ; JIA, ZHAOZHONG J ; BAUER, SHAWN M ; KANE, BRIAN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CA2816219C3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2019</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>XU, QING</creatorcontrib><creatorcontrib>PANDEY, ANJALI</creatorcontrib><creatorcontrib>SONG, YONGHONG</creatorcontrib><creatorcontrib>JIA, ZHAOZHONG J</creatorcontrib><creatorcontrib>BAUER, SHAWN M</creatorcontrib><creatorcontrib>KANE, BRIAN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>XU, QING</au><au>PANDEY, ANJALI</au><au>SONG, YONGHONG</au><au>JIA, ZHAOZHONG J</au><au>BAUER, SHAWN M</au><au>KANE, BRIAN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>NICOTINAMIDES AS SYK MODULATORS</title><date>2019-10-29</date><risdate>2019</risdate><abstract>The present application is directed to compounds of the following formula and pharmaceutically acceptable salts, esters, and prodrugs thereof which are inhibitors of Syk kinase. Also disclosed are intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition Syk kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by Syk kinase activity, such as Non Hodgkin's Lymphoma. (see above formula)
La présente invention concerne des composés de formule I et des sels, esters et promédicaments pharmaceutiquement acceptables de ceux-ci, qui sont des inhibiteurs de la Syk kinase. La présente invention concerne également des intermédiaires utilisés dans la fabrication de tels composés, la préparation d'un tel composé, des compositions pharmaceutiques contenant un tel composé, des procédés d'inhibition de l'activité Syk kinase, des procédés d'inhibition de l'agrégation de plaquettes, et des méthodes de prévention ou de traitement d'un certain nombre d'états pathologiques à médiation au moins en partie par l'activité Syk kinase, tels que le lymphome non hodgkinien.</abstract><oa>free_for_read</oa></addata></record> |
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subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
title | NICOTINAMIDES AS SYK MODULATORS |
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