HETERO RING-FUSED IMIDAZOLE DERIVATIVE HAVING AMPK ACTIVATING EFFECT
Provided is a compound useful as an AMPK activator. A compound represented by formula (I), a pharmaceutically acceptable salt thereof or a solvate of the same. In formula (I), the moiety represented by (II) is (III); R1s independently represent halogen, hydroxy, cyano, nitro, carboxy, substituted or...
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| creator | IWATSU, MASAFUMI INO, AKIRA TONOGAKI, KEISUKE KOJIMA, EIICHI FUJIOKA, MASAHIKO KATOU, MANABU TANAKA, NOBUYUKI |
| description | Provided is a compound useful as an AMPK activator. A compound represented by formula (I), a pharmaceutically acceptable salt thereof or a solvate of the same. In formula (I), the moiety represented by (II) is (III); R1s independently represent halogen, hydroxy, cyano, nitro, carboxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl or the like; m is an integer of 0-3; R2 represents hydrogen or substituted or unsubstituted alkyl; X represents -O-; and Y represents substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl.
L'invention concerne un composé utile en tant qu'activateur de l'AMPK. L'invention concerne un composé représenté par la formule (I), un sel pharmaceutiquement acceptable de celui-ci ou un solvate de ceux-ci. Dans la formule (I), la fraction représentée par (II) est (III); les R1 représentent indépendamment halogène, hydroxy, cyano, nitro, carboxy, alkyle substitué ou non substitué, acényle substitué ou non substitué ou similaires; m est un entier compris entre 0 et 3; R2 représente hydrogène ou alkyle substitué ou non substitué; X représente -O-; et Y représente aryle substitué ou non substitué ou hétéroaryle substitué ou non substitué. |
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L'invention concerne un composé utile en tant qu'activateur de l'AMPK. L'invention concerne un composé représenté par la formule (I), un sel pharmaceutiquement acceptable de celui-ci ou un solvate de ceux-ci. Dans la formule (I), la fraction représentée par (II) est (III); les R1 représentent indépendamment halogène, hydroxy, cyano, nitro, carboxy, alkyle substitué ou non substitué, acényle substitué ou non substitué ou similaires; m est un entier compris entre 0 et 3; R2 représente hydrogène ou alkyle substitué ou non substitué; X représente -O-; et Y représente aryle substitué ou non substitué ou hétéroaryle substitué ou non substitué.</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2018</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20180717&DB=EPODOC&CC=CA&NR=2811025C$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20180717&DB=EPODOC&CC=CA&NR=2811025C$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>IWATSU, MASAFUMI</creatorcontrib><creatorcontrib>INO, AKIRA</creatorcontrib><creatorcontrib>TONOGAKI, KEISUKE</creatorcontrib><creatorcontrib>KOJIMA, EIICHI</creatorcontrib><creatorcontrib>FUJIOKA, MASAHIKO</creatorcontrib><creatorcontrib>KATOU, MANABU</creatorcontrib><creatorcontrib>TANAKA, NOBUYUKI</creatorcontrib><title>HETERO RING-FUSED IMIDAZOLE DERIVATIVE HAVING AMPK ACTIVATING EFFECT</title><description>Provided is a compound useful as an AMPK activator. A compound represented by formula (I), a pharmaceutically acceptable salt thereof or a solvate of the same. In formula (I), the moiety represented by (II) is (III); R1s independently represent halogen, hydroxy, cyano, nitro, carboxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl or the like; m is an integer of 0-3; R2 represents hydrogen or substituted or unsubstituted alkyl; X represents -O-; and Y represents substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl.
L'invention concerne un composé utile en tant qu'activateur de l'AMPK. L'invention concerne un composé représenté par la formule (I), un sel pharmaceutiquement acceptable de celui-ci ou un solvate de ceux-ci. Dans la formule (I), la fraction représentée par (II) est (III); les R1 représentent indépendamment halogène, hydroxy, cyano, nitro, carboxy, alkyle substitué ou non substitué, acényle substitué ou non substitué ou similaires; m est un entier compris entre 0 et 3; R2 représente hydrogène ou alkyle substitué ou non substitué; X représente -O-; et Y représente aryle substitué ou non substitué ou hétéroaryle substitué ou non substitué.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2018</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZHDxcA1xDfJXCPL0c9d1Cw12dVHw9PV0cYzy93FVcHEN8gxzDPEMc1XwcAwDqlBw9A3wVnB0DgELA_mubm6uziE8DKxpiTnFqbxQmptB3s01xNlDN7UgPz61uCAxOTUvtSTe2dHIwtDQwMjU2ZiwCgCo9irA</recordid><startdate>20180717</startdate><enddate>20180717</enddate><creator>IWATSU, MASAFUMI</creator><creator>INO, AKIRA</creator><creator>TONOGAKI, KEISUKE</creator><creator>KOJIMA, EIICHI</creator><creator>FUJIOKA, MASAHIKO</creator><creator>KATOU, MANABU</creator><creator>TANAKA, NOBUYUKI</creator><scope>EVB</scope></search><sort><creationdate>20180717</creationdate><title>HETERO RING-FUSED IMIDAZOLE DERIVATIVE HAVING AMPK ACTIVATING EFFECT</title><author>IWATSU, MASAFUMI ; INO, AKIRA ; TONOGAKI, KEISUKE ; KOJIMA, EIICHI ; FUJIOKA, MASAHIKO ; KATOU, MANABU ; TANAKA, NOBUYUKI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CA2811025C3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2018</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>IWATSU, MASAFUMI</creatorcontrib><creatorcontrib>INO, AKIRA</creatorcontrib><creatorcontrib>TONOGAKI, KEISUKE</creatorcontrib><creatorcontrib>KOJIMA, EIICHI</creatorcontrib><creatorcontrib>FUJIOKA, MASAHIKO</creatorcontrib><creatorcontrib>KATOU, MANABU</creatorcontrib><creatorcontrib>TANAKA, NOBUYUKI</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>IWATSU, MASAFUMI</au><au>INO, AKIRA</au><au>TONOGAKI, KEISUKE</au><au>KOJIMA, EIICHI</au><au>FUJIOKA, MASAHIKO</au><au>KATOU, MANABU</au><au>TANAKA, NOBUYUKI</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>HETERO RING-FUSED IMIDAZOLE DERIVATIVE HAVING AMPK ACTIVATING EFFECT</title><date>2018-07-17</date><risdate>2018</risdate><abstract>Provided is a compound useful as an AMPK activator. A compound represented by formula (I), a pharmaceutically acceptable salt thereof or a solvate of the same. In formula (I), the moiety represented by (II) is (III); R1s independently represent halogen, hydroxy, cyano, nitro, carboxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl or the like; m is an integer of 0-3; R2 represents hydrogen or substituted or unsubstituted alkyl; X represents -O-; and Y represents substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl.
L'invention concerne un composé utile en tant qu'activateur de l'AMPK. L'invention concerne un composé représenté par la formule (I), un sel pharmaceutiquement acceptable de celui-ci ou un solvate de ceux-ci. Dans la formule (I), la fraction représentée par (II) est (III); les R1 représentent indépendamment halogène, hydroxy, cyano, nitro, carboxy, alkyle substitué ou non substitué, acényle substitué ou non substitué ou similaires; m est un entier compris entre 0 et 3; R2 représente hydrogène ou alkyle substitué ou non substitué; X représente -O-; et Y représente aryle substitué ou non substitué ou hétéroaryle substitué ou non substitué.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | HETERO RING-FUSED IMIDAZOLE DERIVATIVE HAVING AMPK ACTIVATING EFFECT |
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