TARGETED GAS-FILLED MICROVESICLES

An aqueous suspension comprising a gas-filed microvesicle is provided. The microvesicle comprises a targeting construct comprising: an amphiphilic compound; and a polypeptide consisting of at most 200 amino acid residues and comprising at least amino acids 5-16 as set forth in SEQ ID NO:1. The polyp...

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Bibliographische Detailangaben
Hauptverfasser:	GUILBERT-BRIGGER, IRENE, BETTINGER, THIERRY, CHERKAOUI, SAMIR, LAMY, BERNARD, BUSSAT, PHILIPPE
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	An aqueous suspension comprising a gas-filed microvesicle is provided. The microvesicle comprises a targeting construct comprising: an amphiphilic compound; and a polypeptide consisting of at most 200 amino acid residues and comprising at least amino acids 5-16 as set forth in SEQ ID NO:1. The polypeptide is in dimeric form and is covalently associated with the amphiphilic compound. The gas-filled microvesicles can be used in ultrasound imaging by administering an effective amount of a suspension of the gas-filled microvesicles to a patient and subjecting the patient to ultrasound imaging. L'invention concerne des microvésicules remplies de gaz associées à un polypeptide comprenant une séquence d'acides aminés, laquelle présente une affinité de liaison pour les sélectines, en particulier la P-séléctine. Les microvésicules remplies de gaz peuvent servir dans l'imagerie ultrasonore.