ANTIBODIES WITH MODIFIED ISOELECTRIC POINTS
The invention relates generally to compositions and methods for altering the isoelectric point of an antibody, and in some cases, resulting in improved plasma pharmacokinetics, e.g. increased serum half-life in vivo. L'invention concerne de manière générale des compositions et des procédés pour...
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| creator | DAHIYAT, BASSIL I BERNETT, MATTHEW J LAZAR, GREGORY A |
| description | The invention relates generally to compositions and methods for altering the isoelectric point of an antibody, and in some cases, resulting in improved plasma pharmacokinetics, e.g. increased serum half-life in vivo.
L'invention concerne de manière générale des compositions et des procédés pour modifier le point isoélectrique d'un anticorps, ce qui permet, dans certains cas, d'améliorer la pharmacocinétique plasmatique, par exemple d'augmenter la demi-vie dans le sérum in vivo. |
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L'invention concerne de manière générale des compositions et des procédés pour modifier le point isoélectrique d'un anticorps, ce qui permet, dans certains cas, d'améliorer la pharmacocinétique plasmatique, par exemple d'augmenter la demi-vie dans le sérum in vivo.</description><language>eng ; fre</language><subject>CHEMISTRY ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES</subject><creationdate>2019</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190514&DB=EPODOC&CC=CA&NR=2806252C$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190514&DB=EPODOC&CC=CA&NR=2806252C$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>DAHIYAT, BASSIL I</creatorcontrib><creatorcontrib>BERNETT, MATTHEW J</creatorcontrib><creatorcontrib>LAZAR, GREGORY A</creatorcontrib><title>ANTIBODIES WITH MODIFIED ISOELECTRIC POINTS</title><description>The invention relates generally to compositions and methods for altering the isoelectric point of an antibody, and in some cases, resulting in improved plasma pharmacokinetics, e.g. increased serum half-life in vivo.
L'invention concerne de manière générale des compositions et des procédés pour modifier le point isoélectrique d'un anticorps, ce qui permet, dans certains cas, d'améliorer la pharmacocinétique plasmatique, par exemple d'augmenter la demi-vie dans le sérum in vivo.</description><subject>CHEMISTRY</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2019</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNB29AvxdPJ38XQNVgj3DPFQ8AWy3TxdXRQ8g_1dfVydQ4I8nRUC_D39QoJ5GFjTEnOKU3mhNDeDvJtriLOHbmpBfnxqcUFicmpeakm8s6ORhYGZkamRszFhFQDvXSQc</recordid><startdate>20190514</startdate><enddate>20190514</enddate><creator>DAHIYAT, BASSIL I</creator><creator>BERNETT, MATTHEW J</creator><creator>LAZAR, GREGORY A</creator><scope>EVB</scope></search><sort><creationdate>20190514</creationdate><title>ANTIBODIES WITH MODIFIED ISOELECTRIC POINTS</title><author>DAHIYAT, BASSIL I ; BERNETT, MATTHEW J ; LAZAR, GREGORY A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CA2806252C3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2019</creationdate><topic>CHEMISTRY</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><toplevel>online_resources</toplevel><creatorcontrib>DAHIYAT, BASSIL I</creatorcontrib><creatorcontrib>BERNETT, MATTHEW J</creatorcontrib><creatorcontrib>LAZAR, GREGORY A</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>DAHIYAT, BASSIL I</au><au>BERNETT, MATTHEW J</au><au>LAZAR, GREGORY A</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>ANTIBODIES WITH MODIFIED ISOELECTRIC POINTS</title><date>2019-05-14</date><risdate>2019</risdate><abstract>The invention relates generally to compositions and methods for altering the isoelectric point of an antibody, and in some cases, resulting in improved plasma pharmacokinetics, e.g. increased serum half-life in vivo.
L'invention concerne de manière générale des compositions et des procédés pour modifier le point isoélectrique d'un anticorps, ce qui permet, dans certains cas, d'améliorer la pharmacocinétique plasmatique, par exemple d'augmenter la demi-vie dans le sérum in vivo.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY METALLURGY ORGANIC CHEMISTRY PEPTIDES |
| title | ANTIBODIES WITH MODIFIED ISOELECTRIC POINTS |
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