SYNTHESIS AND ANTICANCER ACTIVITY OF ARYL AND HETEROARYL-QUINOLIN DERIVATIVES

Anticancer activity of aryl and heteroaryl-quinolin derivatives. The derivatives have a formula T. in which R is hydrogen, PO(OH)2, P(=0)(0-(Ci-C18)alkylenephenyl))2, P(=0)(OH)(0M), or P(=0)(0M)2; W is 2-halophenyl, 3-halophenyl, or 4-halophenyl; R5 is (Ci-C18)alkoxy, hydroxyl, or 0R8; R6 is hydroxy...

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Hauptverfasser:	LEE, KUO-HSIUNG, CHOU, LIN, HUANG, CHI-HUNG, WAY, TZONG-DER, YANG, JAI-SING, KUO, SHENGU, CHUNG, JING-GUNG, HUANG, LI-JIAU, WU, TIAN-SHUNG, TSAI, MENG-TUNG
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Sprache:	eng ; fre
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator	LEE, KUO-HSIUNG CHOU, LIN HUANG, CHI-HUNG WAY, TZONG-DER YANG, JAI-SING KUO, SHENGU CHUNG, JING-GUNG HUANG, LI-JIAU WU, TIAN-SHUNG TSAI, MENG-TUNG
description	Anticancer activity of aryl and heteroaryl-quinolin derivatives. The derivatives have a formula T. in which R is hydrogen, PO(OH)2, P(=0)(0-(Ci-C18)alkylenephenyl))2, P(=0)(OH)(0M), or P(=0)(0M)2; W is 2-halophenyl, 3-halophenyl, or 4-halophenyl; R5 is (Ci-C18)alkoxy, hydroxyl, or 0R8; R6 is hydroxyl, or (Ci-C18)alkoxy; R7 is hydrogen; R8 is PO(OH)2, P(=0)(0-(Ci-C18)alkylenephenyl)2. P(=0)(OH)(0M), or P(=0)(0M)2, and M is a monovalent or divalent metal ion, or alkylammoniurn ion. L'invention concerne une classe de composés qui sont des dérivés et des analogues d'aryl- et d'hétéroaryl-quinoléine. La présente invention concerne en outre la synthèse et l'utilisation des dérivés et analogues d'aryl- et d'hétéroaryl-quinoléine pour des activités anticancéreuses.
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The derivatives have a formula T. in which R is hydrogen, PO(OH)2, P(=0)(0-(Ci-C18)alkylenephenyl))2, P(=0)(OH)(0M), or P(=0)(0M)2; W is 2-halophenyl, 3-halophenyl, or 4-halophenyl; R5 is (Ci-C18)alkoxy, hydroxyl, or 0R8; R6 is hydroxyl, or (Ci-C18)alkoxy; R7 is hydrogen; R8 is PO(OH)2, P(=0)(0-(Ci-C18)alkylenephenyl)2. P(=0)(OH)(0M), or P(=0)(0M)2, and M is a monovalent or divalent metal ion, or alkylammoniurn ion. L'invention concerne une classe de composés qui sont des dérivés et des analogues d'aryl- et d'hétéroaryl-quinoléine. 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The derivatives have a formula T. in which R is hydrogen, PO(OH)2, P(=0)(0-(Ci-C18)alkylenephenyl))2, P(=0)(OH)(0M), or P(=0)(0M)2; W is 2-halophenyl, 3-halophenyl, or 4-halophenyl; R5 is (Ci-C18)alkoxy, hydroxyl, or 0R8; R6 is hydroxyl, or (Ci-C18)alkoxy; R7 is hydrogen; R8 is PO(OH)2, P(=0)(0-(Ci-C18)alkylenephenyl)2. P(=0)(OH)(0M), or P(=0)(0M)2, and M is a monovalent or divalent metal ion, or alkylammoniurn ion. L'invention concerne une classe de composés qui sont des dérivés et des analogues d'aryl- et d'hétéroaryl-quinoléine. La présente invention concerne en outre la synthèse et l'utilisation des dérivés et analogues d'aryl- et d'hétéroaryl-quinoléine pour des activités anticancéreuses.</abstract><oa>free_for_read</oa></addata></record>
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subjects	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title	SYNTHESIS AND ANTICANCER ACTIVITY OF ARYL AND HETEROARYL-QUINOLIN DERIVATIVES
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