ANTIDEPRESSANT, NEUROPROTECTANT, AMYLOID .BETA. DEPOSITION INHIBITOR OR AGE RETARDANT CONTAINING HETEROCYCLIC COMPOUND HAVING SPECIFIC STRUCTURE

The present invention provides an antidepressant, neuroprotectant, amyloid .beta. deposition inhibitor, or age retardant composition comprising containing a heterocyclic compound having the general Formula (I): (see formula I) or a pharmaceutically acceptable salt or hydrate thereof. The structural unit (see formula II) being selected from (see formula III) R1 and R2 each are one or more functional groups independently selected from the group consisting of a hydrogen atom, halogen atom, hydroxy group, amino group, acetylamino group, benzylamino group, trifluoromethyl group, C1-C6 alkyl group, C1-C6 alkoxy group, and -O-(CH2)n-R5, wherein R5 is a vinyl group, C3-C6 cycloalkyl group, or phenyl group, and n is 0 or 1. R3 and R4 each are one or more functional groups independently selected from the group consisting of a hydrogen atom, C1-C6 alkyl group, C3-C8 cycloalkyl group, and -CH(R7)-R6; alternatively, R3 and R4 together form a spiro ring having the general formula (IV): (see formula IV) R6 is one or more functional groups selected from the group consisting of a vinyl group, ethinyl group, phenyl optionally substituted by a C1-C6 alkyl group, C1-C6 alkoxy group, hydroxy group, 1 or 2 halogen atoms, di C1-C6 alkylamino group, cyano group, nitro group, carboxy group, or phenyl group, phenethyl group, pyridyl group, thienyl group, and furyl group. The above R7 is a hydrogen atom or C1-C6 alkyl group. The structural unit B is one or more structural units selected from multiple types of structural units having the general Formula (V). The structural unit B binds at a position marked by * in the general Formula (V) to form a spiro ring. (see formula V) R8 is one or more functional groups selected from the group consisting of a hydrogen atom, halogen atom, hydroxy group, C1-C6 alkoxy group, cyano group, and trifluoromethyl group. La présente invention concerne une composition d'antidépresseur, de neuroprotecteur, d'inhibiteur de dépôt de bêta-amyloïde ou d'agent anti-âge comportant un composé hétérocyclique ayant la formule générale suivante (1) : (voir la formule 1) ou un sel pharmaceutiquement acceptable ou un hydrate de celui-ci. L'unité structurale (voir la formule II) étant sélectionnée à partir de (voir la formule III) R1 et R2, chacun correspondant à un ou à plusieurs groupes fonctionnels indépendamment sélectionnés parmi le groupe comprenant un atome d'hydrogène, un atome d'halogène, un groupe hydroxy, un groupe amino, un groupe acétylamino, un groupe be