IRE-1.ALPHA. INHIBITORS
Compounds which directly inhibit IRE-1 ot activity in vitro, prodrugs, and pharmaceutically acceptable salts thereof Such compounds and prodrugs are useful for treating diseases associated with the unfolded protein response or with regulated IRE1-dependent decay (RIDD) and can be used as single agen...
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| creator | ZUBOVICS, ZOLTAN TORO, ANDRAS WU, ZHIPENG YANG, YUN PATTERSON, JOHN BRUCE ZENG, QINGPING WADE, WARREN STANFIELD |
| description | Compounds which directly inhibit IRE-1 ot activity in vitro, prodrugs, and pharmaceutically acceptable salts thereof Such compounds and prodrugs are useful for treating diseases associated with the unfolded protein response or with regulated IRE1-dependent decay (RIDD) and can be used as single agents or in combination therapies. Compounds of the present invention include those of formula (A-I): (see formula A-I)
La présente invention concerne des composés qui inhibent directement l'activité IRE-1a in vitro, des promédicaments, et leurs sels pharmaceutiquement acceptables. Lesdits composés et lesdits promédicaments sont utiles dans le traitement de maladies associées à la réponse aux protéines dépliées ou à la désintégration dépendante de l'IRE1 régulée (RIDD), et peuvent être utilisés en tant qu'agents simples ou dans des polythérapies. |
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La présente invention concerne des composés qui inhibent directement l'activité IRE-1a in vitro, des promédicaments, et leurs sels pharmaceutiquement acceptables. Lesdits composés et lesdits promédicaments sont utiles dans le traitement de maladies associées à la réponse aux protéines dépliées ou à la désintégration dépendante de l'IRE1 régulée (RIDD), et peuvent être utilisés en tant qu'agents simples ou dans des polythérapies.</description><language>eng ; fre</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2016</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20160209&DB=EPODOC&CC=CA&NR=2795350C$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76318</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20160209&DB=EPODOC&CC=CA&NR=2795350C$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>ZUBOVICS, ZOLTAN</creatorcontrib><creatorcontrib>TORO, ANDRAS</creatorcontrib><creatorcontrib>WU, ZHIPENG</creatorcontrib><creatorcontrib>YANG, YUN</creatorcontrib><creatorcontrib>PATTERSON, JOHN BRUCE</creatorcontrib><creatorcontrib>ZENG, QINGPING</creatorcontrib><creatorcontrib>WADE, WARREN STANFIELD</creatorcontrib><title>IRE-1.ALPHA. INHIBITORS</title><description>Compounds which directly inhibit IRE-1 ot activity in vitro, prodrugs, and pharmaceutically acceptable salts thereof Such compounds and prodrugs are useful for treating diseases associated with the unfolded protein response or with regulated IRE1-dependent decay (RIDD) and can be used as single agents or in combination therapies. Compounds of the present invention include those of formula (A-I): (see formula A-I)
La présente invention concerne des composés qui inhibent directement l'activité IRE-1a in vitro, des promédicaments, et leurs sels pharmaceutiquement acceptables. Lesdits composés et lesdits promédicaments sont utiles dans le traitement de maladies associées à la réponse aux protéines dépliées ou à la désintégration dépendante de l'IRE1 régulée (RIDD), et peuvent être utilisés en tant qu'agents simples ou dans des polythérapies.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2016</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZBD3DHLVNdRz9AnwcNRT8PTz8HTyDPEPCuZhYE1LzClO5YXS3Azybq4hzh66qQX58anFBYnJqXmpJfHOjkbmlqbGpgbOxoRVAAA6eR49</recordid><startdate>20160209</startdate><enddate>20160209</enddate><creator>ZUBOVICS, ZOLTAN</creator><creator>TORO, ANDRAS</creator><creator>WU, ZHIPENG</creator><creator>YANG, YUN</creator><creator>PATTERSON, JOHN BRUCE</creator><creator>ZENG, QINGPING</creator><creator>WADE, WARREN STANFIELD</creator><scope>EVB</scope></search><sort><creationdate>20160209</creationdate><title>IRE-1.ALPHA. INHIBITORS</title><author>ZUBOVICS, ZOLTAN ; TORO, ANDRAS ; WU, ZHIPENG ; YANG, YUN ; PATTERSON, JOHN BRUCE ; ZENG, QINGPING ; WADE, WARREN STANFIELD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CA2795350C3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2016</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>ZUBOVICS, ZOLTAN</creatorcontrib><creatorcontrib>TORO, ANDRAS</creatorcontrib><creatorcontrib>WU, ZHIPENG</creatorcontrib><creatorcontrib>YANG, YUN</creatorcontrib><creatorcontrib>PATTERSON, JOHN BRUCE</creatorcontrib><creatorcontrib>ZENG, QINGPING</creatorcontrib><creatorcontrib>WADE, WARREN STANFIELD</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>ZUBOVICS, ZOLTAN</au><au>TORO, ANDRAS</au><au>WU, ZHIPENG</au><au>YANG, YUN</au><au>PATTERSON, JOHN BRUCE</au><au>ZENG, QINGPING</au><au>WADE, WARREN STANFIELD</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>IRE-1.ALPHA. INHIBITORS</title><date>2016-02-09</date><risdate>2016</risdate><abstract>Compounds which directly inhibit IRE-1 ot activity in vitro, prodrugs, and pharmaceutically acceptable salts thereof Such compounds and prodrugs are useful for treating diseases associated with the unfolded protein response or with regulated IRE1-dependent decay (RIDD) and can be used as single agents or in combination therapies. Compounds of the present invention include those of formula (A-I): (see formula A-I)
La présente invention concerne des composés qui inhibent directement l'activité IRE-1a in vitro, des promédicaments, et leurs sels pharmaceutiquement acceptables. Lesdits composés et lesdits promédicaments sont utiles dans le traitement de maladies associées à la réponse aux protéines dépliées ou à la désintégration dépendante de l'IRE1 régulée (RIDD), et peuvent être utilisés en tant qu'agents simples ou dans des polythérapies.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE |
| title | IRE-1.ALPHA. INHIBITORS |
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