IRE-1.ALPHA. INHIBITORS

Compounds which directly inhibit IRE-1 ot activity in vitro, prodrugs, and pharmaceutically acceptable salts thereof Such compounds and prodrugs are useful for treating diseases associated with the unfolded protein response or with regulated IRE1-dependent decay (RIDD) and can be used as single agen...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	ZUBOVICS, ZOLTAN, TORO, ANDRAS, WU, ZHIPENG, YANG, YUN, PATTERSON, JOHN BRUCE, ZENG, QINGPING, WADE, WARREN STANFIELD
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Compounds which directly inhibit IRE-1 ot activity in vitro, prodrugs, and pharmaceutically acceptable salts thereof Such compounds and prodrugs are useful for treating diseases associated with the unfolded protein response or with regulated IRE1-dependent decay (RIDD) and can be used as single agents or in combination therapies. Compounds of the present invention include those of formula (A-I): (see formula A-I) La présente invention concerne des composés qui inhibent directement l'activité IRE-1a in vitro, des promédicaments, et leurs sels pharmaceutiquement acceptables. Lesdits composés et lesdits promédicaments sont utiles dans le traitement de maladies associées à la réponse aux protéines dépliées ou à la désintégration dépendante de l'IRE1 régulée (RIDD), et peuvent être utilisés en tant qu'agents simples ou dans des polythérapies.