CROSSLINKED POLYVINYLAMINE, POLYALLYLAMINE, AND POLYETHYLENEIMINE FOR USE AS BILE ACID SEQUESTRANTS

CROSSLINKED POLYVINYLAMINE, POLYALLYLAMINE, AND POLYETHYLENEIMINE FOR USE AS BILE ACID SEQUESTRANTS

The present invention provides a crosslinked amine and amide polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercho...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: CONNOR, ERIC, MANSKY, PAUL, LEE, ANGELA, KOPPING, JORDON, GOKA, ELIZABETH, SALAYMEH, FALEH, ZHANG, HONGMIN, QUAKER, GRACE, COPE, MICHAEL JAMES, SHAO, JUN, MU, YONGQI, BERGBREITER, DAVID, LEES, INEZ, MADSEN, DEIDRE, BIYANI, KALPESH, HECKER, SCOTT
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
COMPOSITIONS BASED THEREON
COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVINGCARBON-TO-CARBON UNSATURATED BONDS
METALLURGY
ORGANIC MACROMOLECULAR COMPOUNDS
THEIR PREPARATION OR CHEMICAL WORKING-UP
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Beschreibung
Zusammenfassung:The present invention provides a crosslinked amine and amide polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercholesteremia, diabetes, pruritis, irritable bowel syndrome-diarrhea (IBS-D), bile acid malabsorption, and the like. La présente invention concerne des polymères réticulés d'amine et d'amide efficaces pour la liaison et l'élimination des sels biliaires du tractus gastro-intestinal. Ces polymères liant l'acide biliaire ou les compositions pharmaceutiques de ceux-ci peuvent être administrés aux sujets pour traiter diverses pathologies, incluant l'hypercholestérolémie, le diabète, le prurit, le syndrome-diarrhée du côlon irritable (IBS-D), la malabsorption de l'acide biliaire et d'autres.