ANTI-GCC ANTIBODY MOLECULES AND RELATED COMPOSITIONS AND METHODS
Antibodies and antigen-binding fragments of antibodies that bind GCC are disclosed. The antibodies bind an extracellular domain of GCC and can be internalized. In some embodiments, the antibodies are humanized, chimeric or human. Nucleic acids and vectors encoding the antibodies or portions thereof,...
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| creator | QIN, SHIXIN GREENFIELD, EDWARD A NAM, SAMUEL S O'KEEFE, THERESA BABCOOK, JOHN |
| description | Antibodies and antigen-binding fragments of antibodies that bind GCC are disclosed. The antibodies bind an extracellular domain of GCC and can be internalized. In some embodiments, the antibodies are humanized, chimeric or human. Nucleic acids and vectors encoding the antibodies or portions thereof, recombinant cells that contain the nucleic acids, and compositions comprising the antibodies or antigen-binding fragments are also disclosed. The invention also provides therapeutic and diagnostic methods utilizing the antibodies and antigen-binding fragments provided herein.
La présente invention concerne des anticorps et des fragments se liant aux antigènes d'anticorps qui se lient à GCC. Les anticorps se lient à un domaine extracellulaire de GCC et peuvent être internalisés. Dans certains modes de réalisation, les anticorps sont humanisés, chimériques ou humains. La présente invention concerne également des acides nucléiques et des vecteurs codant pour les anticorps ou des parties de ceux-ci, des cellules recombinantes qui contiennent les acides nucléiques, et des compositions qui comprennent les anticorps ou les fragments se liant aux antigènes. L'invention concerne également des procédés thérapeutiques et diagnostiques utilisant les anticorps et les fragments liant l'antigène fournis dans la présente invention. |
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La présente invention concerne des anticorps et des fragments se liant aux antigènes d'anticorps qui se lient à GCC. Les anticorps se lient à un domaine extracellulaire de GCC et peuvent être internalisés. Dans certains modes de réalisation, les anticorps sont humanisés, chimériques ou humains. La présente invention concerne également des acides nucléiques et des vecteurs codant pour les anticorps ou des parties de ceux-ci, des cellules recombinantes qui contiennent les acides nucléiques, et des compositions qui comprennent les anticorps ou les fragments se liant aux antigènes. L'invention concerne également des procédés thérapeutiques et diagnostiques utilisant les anticorps et les fragments liant l'antigène fournis dans la présente invention.</description><language>eng ; fre</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2019</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190326&DB=EPODOC&CC=CA&NR=2774032C$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190326&DB=EPODOC&CC=CA&NR=2774032C$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>QIN, SHIXIN</creatorcontrib><creatorcontrib>GREENFIELD, EDWARD A</creatorcontrib><creatorcontrib>NAM, SAMUEL S</creatorcontrib><creatorcontrib>O'KEEFE, THERESA</creatorcontrib><creatorcontrib>BABCOOK, JOHN</creatorcontrib><title>ANTI-GCC ANTIBODY MOLECULES AND RELATED COMPOSITIONS AND METHODS</title><description>Antibodies and antigen-binding fragments of antibodies that bind GCC are disclosed. The antibodies bind an extracellular domain of GCC and can be internalized. In some embodiments, the antibodies are humanized, chimeric or human. Nucleic acids and vectors encoding the antibodies or portions thereof, recombinant cells that contain the nucleic acids, and compositions comprising the antibodies or antigen-binding fragments are also disclosed. The invention also provides therapeutic and diagnostic methods utilizing the antibodies and antigen-binding fragments provided herein.
La présente invention concerne des anticorps et des fragments se liant aux antigènes d'anticorps qui se lient à GCC. Les anticorps se lient à un domaine extracellulaire de GCC et peuvent être internalisés. Dans certains modes de réalisation, les anticorps sont humanisés, chimériques ou humains. La présente invention concerne également des acides nucléiques et des vecteurs codant pour les anticorps ou des parties de ceux-ci, des cellules recombinantes qui contiennent les acides nucléiques, et des compositions qui comprennent les anticorps ou les fragments se liant aux antigènes. L'invention concerne également des procédés thérapeutiques et diagnostiques utilisant les anticorps et les fragments liant l'antigène fournis dans la présente invention.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2019</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZHBw9Avx1HV3dlYAMZz8XSIVfP19XJ1DfVyDgUIuCkGuPo4hri4Kzv6-Af7BniGe_n4QCV_XEA9_l2AeBta0xJziVF4ozc0g7-Ya4uyhm1qQH59aXJCYnJqXWhLv7Ghkbm5iYGzkbExYBQD3yimq</recordid><startdate>20190326</startdate><enddate>20190326</enddate><creator>QIN, SHIXIN</creator><creator>GREENFIELD, EDWARD A</creator><creator>NAM, SAMUEL S</creator><creator>O'KEEFE, THERESA</creator><creator>BABCOOK, JOHN</creator><scope>EVB</scope></search><sort><creationdate>20190326</creationdate><title>ANTI-GCC ANTIBODY MOLECULES AND RELATED COMPOSITIONS AND METHODS</title><author>QIN, SHIXIN ; GREENFIELD, EDWARD A ; NAM, SAMUEL S ; O'KEEFE, THERESA ; BABCOOK, JOHN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CA2774032C3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2019</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>QIN, SHIXIN</creatorcontrib><creatorcontrib>GREENFIELD, EDWARD A</creatorcontrib><creatorcontrib>NAM, SAMUEL S</creatorcontrib><creatorcontrib>O'KEEFE, THERESA</creatorcontrib><creatorcontrib>BABCOOK, JOHN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>QIN, SHIXIN</au><au>GREENFIELD, EDWARD A</au><au>NAM, SAMUEL S</au><au>O'KEEFE, THERESA</au><au>BABCOOK, JOHN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>ANTI-GCC ANTIBODY MOLECULES AND RELATED COMPOSITIONS AND METHODS</title><date>2019-03-26</date><risdate>2019</risdate><abstract>Antibodies and antigen-binding fragments of antibodies that bind GCC are disclosed. The antibodies bind an extracellular domain of GCC and can be internalized. In some embodiments, the antibodies are humanized, chimeric or human. Nucleic acids and vectors encoding the antibodies or portions thereof, recombinant cells that contain the nucleic acids, and compositions comprising the antibodies or antigen-binding fragments are also disclosed. The invention also provides therapeutic and diagnostic methods utilizing the antibodies and antigen-binding fragments provided herein.
La présente invention concerne des anticorps et des fragments se liant aux antigènes d'anticorps qui se lient à GCC. Les anticorps se lient à un domaine extracellulaire de GCC et peuvent être internalisés. Dans certains modes de réalisation, les anticorps sont humanisés, chimériques ou humains. La présente invention concerne également des acides nucléiques et des vecteurs codant pour les anticorps ou des parties de ceux-ci, des cellules recombinantes qui contiennent les acides nucléiques, et des compositions qui comprennent les anticorps ou les fragments se liant aux antigènes. L'invention concerne également des procédés thérapeutiques et diagnostiques utilisant les anticorps et les fragments liant l'antigène fournis dans la présente invention.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| title | ANTI-GCC ANTIBODY MOLECULES AND RELATED COMPOSITIONS AND METHODS |
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