CRYSTALLINE COMPOUND OF 7-[(3R)-3-AMINO-1-OXO-4-(2,4,5-TRIFLUORPHENYL) BUTYL]-5,6,7,8-TETRAHYDRO-3-(TRI FLUORMETHYL)-1,2,4-TRIAZOLO[4,3-A]PYRAZINE

CRYSTALLINE COMPOUND OF 7-[(3R)-3-AMINO-1-OXO-4-(2,4,5-TRIFLUORPHENYL) BUTYL]-5,6,7,8-TETRAHYDRO-3-(TRI FLUORMETHYL)-1,2,4-TRIAZOLO[4,3-A]PYRAZINE

The present invention relates to a crystalline compound of 7-[(3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine (INN:Sitagliptin) of the formula (1), having fumaric acid or a hydrate thereof, wherein the molar ratio of the compoun...

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Bibliographische Detailangaben
Hauptverfasser: REICHENBAECHER, KATHARINA, BLATTER, FRITZ
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present invention relates to a crystalline compound of 7-[(3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine (INN:Sitagliptin) of the formula (1), having fumaric acid or a hydrate thereof, wherein the molar ratio of the compound of the formula (1) to fumaric acid is 1:0.6 to 1:1.3, and a method for the production thereof.