VACCINE HAVING A PEPTIDE ADJUVANT FOR ELICITING A SPECIFIC IMMUNE RESPONSE TO TREAT VIRAL INFECTION AND OTHER CONDITIONS

VACCINE HAVING A PEPTIDE ADJUVANT FOR ELICITING A SPECIFIC IMMUNE RESPONSE TO TREAT VIRAL INFECTION AND OTHER CONDITIONS

This invention provides a family of immunogenic compositions and vaccines, each containing a target antigen or antigen mixture, and an oligopeptide adjuvant, exemplified by the tripeptide lIe - GIu - Trp. The adjuvant has a low side effect profile, and may be especially effective in generating a rap...

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Hauptverfasser: LALONDE, GUY, SAHNER, DAVID
Format: Patent
Sprache:eng ; fre
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HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator LALONDE, GUY
SAHNER, DAVID
description This invention provides a family of immunogenic compositions and vaccines, each containing a target antigen or antigen mixture, and an oligopeptide adjuvant, exemplified by the tripeptide lIe - GIu - Trp. The adjuvant has a low side effect profile, and may be especially effective in generating a rapid and specific Th1 or cellular immune response where the antigen is poorly immunogenic, or the patient is elderly or immunocompromised. In some circumstances, effectiveness of the vaccine can be substantially enhanced by administering follow-on injections of the tripeptide alone. The vaccine has been used to generate an enhanced response to multiple strains of influenza simultaneously, and is suitable for preventing or treating other infectious and disease conditions.
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title VACCINE HAVING A PEPTIDE ADJUVANT FOR ELICITING A SPECIFIC IMMUNE RESPONSE TO TREAT VIRAL INFECTION AND OTHER CONDITIONS
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