METHOD FOR OBTAINING MYOFIBROBLASTS
L'invention concerne un procédé d'obtention de myofibroblastes. Selon ce procédé : (a) on prépare un échantillon de cellules incluant essentiellement des fibroblastes; et (b) on met en culture cet échantillon de cellules dans un milieu de culture sans sérum. Le but principal visé par l...
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| creator | BARTHEL, ROBERT ROUYER, NICOLAS JACQUES |
| description | L'invention concerne un procédé d'obtention de myofibroblastes. Selon ce procédé : (a) on prépare un échantillon de cellules incluant essentiellement des fibroblastes; et (b) on met en culture cet échantillon de cellules dans un milieu de culture sans sérum. Le but principal visé par l'invention est d'obtenir une population de myofibroblastes, dont les caractéristiques facilitent toute étude de ces cellules, et en particulier une population la plus pure possible en myofibroblastes. Quelques exemples d'application de l'invention sont: identification de biomarqueurs de myofibroblastes, identification de cibles thérapeutiques, identification et validation de composés anticancéreux, modèle in vitro pour le criblage de composés pharmaceutiques ou cosmétiques.
The invention relates to a process for obtention of myofibroblasts. According to this process: (a) a sample of cells essentially comprising fibroblasts is prepared; and (b) this sample of cells is cultured in a serum-free culture medium. The main purpose addressed by the invention is to obtain a population of myofibroblasts, the characteristics whereof facilitate any study of these cells, and in particular as pure as possible a population of myofibroblasts. Some examples of application of the invention are: identification of biomarkers of myofibroblasts, identification of therapeutic targets, identification and validation of anticancer compounds, and an in vitro model for the screening of pharmaceutical or cosmetic compounds. |
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The invention relates to a process for obtention of myofibroblasts. According to this process: (a) a sample of cells essentially comprising fibroblasts is prepared; and (b) this sample of cells is cultured in a serum-free culture medium. The main purpose addressed by the invention is to obtain a population of myofibroblasts, the characteristics whereof facilitate any study of these cells, and in particular as pure as possible a population of myofibroblasts. Some examples of application of the invention are: identification of biomarkers of myofibroblasts, identification of therapeutic targets, identification and validation of anticancer compounds, and an in vitro model for the screening of pharmaceutical or cosmetic compounds.</description><language>eng ; fre</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2011</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20110127&DB=EPODOC&CC=CA&NR=2767929A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20110127&DB=EPODOC&CC=CA&NR=2767929A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>BARTHEL, ROBERT</creatorcontrib><creatorcontrib>ROUYER, NICOLAS JACQUES</creatorcontrib><title>METHOD FOR OBTAINING MYOFIBROBLASTS</title><description>L'invention concerne un procédé d'obtention de myofibroblastes. Selon ce procédé : (a) on prépare un échantillon de cellules incluant essentiellement des fibroblastes; et (b) on met en culture cet échantillon de cellules dans un milieu de culture sans sérum. Le but principal visé par l'invention est d'obtenir une population de myofibroblastes, dont les caractéristiques facilitent toute étude de ces cellules, et en particulier une population la plus pure possible en myofibroblastes. Quelques exemples d'application de l'invention sont: identification de biomarqueurs de myofibroblastes, identification de cibles thérapeutiques, identification et validation de composés anticancéreux, modèle in vitro pour le criblage de composés pharmaceutiques ou cosmétiques.
The invention relates to a process for obtention of myofibroblasts. According to this process: (a) a sample of cells essentially comprising fibroblasts is prepared; and (b) this sample of cells is cultured in a serum-free culture medium. The main purpose addressed by the invention is to obtain a population of myofibroblasts, the characteristics whereof facilitate any study of these cells, and in particular as pure as possible a population of myofibroblasts. Some examples of application of the invention are: identification of biomarkers of myofibroblasts, identification of therapeutic targets, identification and validation of anticancer compounds, and an in vitro model for the screening of pharmaceutical or cosmetic compounds.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2011</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFD2dQ3x8HdRcPMPUvB3CnH09PP0c1fwjfR383QK8nfycQwOCeZhYE1LzClO5YXS3AwKbq4hzh66qQX58anFBYnJqXmpJfHOjkbmZuaWRpaOhsZEKAEAJIkidw</recordid><startdate>20110127</startdate><enddate>20110127</enddate><creator>BARTHEL, ROBERT</creator><creator>ROUYER, NICOLAS JACQUES</creator><scope>EVB</scope></search><sort><creationdate>20110127</creationdate><title>METHOD FOR OBTAINING MYOFIBROBLASTS</title><author>BARTHEL, ROBERT ; ROUYER, NICOLAS JACQUES</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CA2767929A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2011</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>BARTHEL, ROBERT</creatorcontrib><creatorcontrib>ROUYER, NICOLAS JACQUES</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>BARTHEL, ROBERT</au><au>ROUYER, NICOLAS JACQUES</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>METHOD FOR OBTAINING MYOFIBROBLASTS</title><date>2011-01-27</date><risdate>2011</risdate><abstract>L'invention concerne un procédé d'obtention de myofibroblastes. Selon ce procédé : (a) on prépare un échantillon de cellules incluant essentiellement des fibroblastes; et (b) on met en culture cet échantillon de cellules dans un milieu de culture sans sérum. Le but principal visé par l'invention est d'obtenir une population de myofibroblastes, dont les caractéristiques facilitent toute étude de ces cellules, et en particulier une population la plus pure possible en myofibroblastes. Quelques exemples d'application de l'invention sont: identification de biomarqueurs de myofibroblastes, identification de cibles thérapeutiques, identification et validation de composés anticancéreux, modèle in vitro pour le criblage de composés pharmaceutiques ou cosmétiques.
The invention relates to a process for obtention of myofibroblasts. According to this process: (a) a sample of cells essentially comprising fibroblasts is prepared; and (b) this sample of cells is cultured in a serum-free culture medium. The main purpose addressed by the invention is to obtain a population of myofibroblasts, the characteristics whereof facilitate any study of these cells, and in particular as pure as possible a population of myofibroblasts. Some examples of application of the invention are: identification of biomarkers of myofibroblasts, identification of therapeutic targets, identification and validation of anticancer compounds, and an in vitro model for the screening of pharmaceutical or cosmetic compounds.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE |
| title | METHOD FOR OBTAINING MYOFIBROBLASTS |
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