PROCESS FOR PRODUCING CRYSTALS OF POLYMORPHIC 2-(3-CYANO-4-ISOBUTYLOXYPHENYL)-4-METHYL-5-THIAZOLECARBOXYLIC ACID BY POOR-SOLVENT ADDITION METHOD
Disclosed is a process for producing A-form crystals of 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid, comprising: a step of dissolving by heating 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid in one or a plurality of solvents as a good solvent, selected fro...
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creator | TAKEYASU, TAKUMI UEMURA, AKIHITO NOGATA, TOMOAKI |
description | Disclosed is a process for producing A-form crystals of 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid, comprising: a step of dissolving by heating 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid in one or a plurality of solvents as a good solvent, selected from the group consisting of 1-propanol, 2-propanol, ethanol, and acetone; a step of cooling the solution; and a step of adding to the solution a hydrocarbon solvent as a poor solvent.
L'invention porte sur un procédé de fabrication de cristaux de forme A de l'acide 2-(3-cyano-4-isobutyloxyphényl)-4-méthyl-5-thiazole carboxylique. Le procédé comprend l'étape de chauffage et de dissolution de l'acide 2-(3-cyano-4-isobutyloxyphényl)-4-méthyl5-thiazole carboxylique dans un ou plusieurs solvants, en tant que bons solvants, choisis dans le groupe constitué par le 1-propanol, le 2-propanol, l'éthanol et l'acétone, l'étape de refroidissement de la solution, et l'étape d'addition dans un solvant hydrocarboné en tant que solvant médiocre à la solution refroidie. |
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L'invention porte sur un procédé de fabrication de cristaux de forme A de l'acide 2-(3-cyano-4-isobutyloxyphényl)-4-méthyl-5-thiazole carboxylique. Le procédé comprend l'étape de chauffage et de dissolution de l'acide 2-(3-cyano-4-isobutyloxyphényl)-4-méthyl5-thiazole carboxylique dans un ou plusieurs solvants, en tant que bons solvants, choisis dans le groupe constitué par le 1-propanol, le 2-propanol, l'éthanol et l'acétone, l'étape de refroidissement de la solution, et l'étape d'addition dans un solvant hydrocarboné en tant que solvant médiocre à la solution refroidie.</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2017</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20170314&DB=EPODOC&CC=CA&NR=2764603C$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20170314&DB=EPODOC&CC=CA&NR=2764603C$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>TAKEYASU, TAKUMI</creatorcontrib><creatorcontrib>UEMURA, AKIHITO</creatorcontrib><creatorcontrib>NOGATA, TOMOAKI</creatorcontrib><title>PROCESS FOR PRODUCING CRYSTALS OF POLYMORPHIC 2-(3-CYANO-4-ISOBUTYLOXYPHENYL)-4-METHYL-5-THIAZOLECARBOXYLIC ACID BY POOR-SOLVENT ADDITION METHOD</title><description>Disclosed is a process for producing A-form crystals of 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid, comprising: a step of dissolving by heating 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid in one or a plurality of solvents as a good solvent, selected from the group consisting of 1-propanol, 2-propanol, ethanol, and acetone; a step of cooling the solution; and a step of adding to the solution a hydrocarbon solvent as a poor solvent.
L'invention porte sur un procédé de fabrication de cristaux de forme A de l'acide 2-(3-cyano-4-isobutyloxyphényl)-4-méthyl-5-thiazole carboxylique. Le procédé comprend l'étape de chauffage et de dissolution de l'acide 2-(3-cyano-4-isobutyloxyphényl)-4-méthyl5-thiazole carboxylique dans un ou plusieurs solvants, en tant que bons solvants, choisis dans le groupe constitué par le 1-propanol, le 2-propanol, l'éthanol et l'acétone, l'étape de refroidissement de la solution, et l'étape d'addition dans un solvant hydrocarboné en tant que solvant médiocre à la solution refroidie.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2017</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqFjLEKwjAURbs4iPoNvlGHgFitc_qSmkDMK0kU4yJF4iRa0A_xk43g7nQvl3PusHi3jlB6Dw05yF3sUdstoIs-cOOBGmjJxB25VmmEJZuVDCO3xFZMe6r3IRo6xlZJG808jzsZVDRszYLS_ERGInd1Jky2OWoBdcyP5Jgnc5A2ABdCB00WviaJcTG4drdnmvxyVEwbGVCx1D_O6dl3l3RPrzPy5aZaVYsSy__EB4cfP_o</recordid><startdate>20170314</startdate><enddate>20170314</enddate><creator>TAKEYASU, TAKUMI</creator><creator>UEMURA, AKIHITO</creator><creator>NOGATA, TOMOAKI</creator><scope>EVB</scope></search><sort><creationdate>20170314</creationdate><title>PROCESS FOR PRODUCING CRYSTALS OF POLYMORPHIC 2-(3-CYANO-4-ISOBUTYLOXYPHENYL)-4-METHYL-5-THIAZOLECARBOXYLIC ACID BY POOR-SOLVENT ADDITION METHOD</title><author>TAKEYASU, TAKUMI ; UEMURA, AKIHITO ; NOGATA, TOMOAKI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CA2764603C3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2017</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>TAKEYASU, TAKUMI</creatorcontrib><creatorcontrib>UEMURA, AKIHITO</creatorcontrib><creatorcontrib>NOGATA, TOMOAKI</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>TAKEYASU, TAKUMI</au><au>UEMURA, AKIHITO</au><au>NOGATA, TOMOAKI</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PROCESS FOR PRODUCING CRYSTALS OF POLYMORPHIC 2-(3-CYANO-4-ISOBUTYLOXYPHENYL)-4-METHYL-5-THIAZOLECARBOXYLIC ACID BY POOR-SOLVENT ADDITION METHOD</title><date>2017-03-14</date><risdate>2017</risdate><abstract>Disclosed is a process for producing A-form crystals of 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid, comprising: a step of dissolving by heating 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid in one or a plurality of solvents as a good solvent, selected from the group consisting of 1-propanol, 2-propanol, ethanol, and acetone; a step of cooling the solution; and a step of adding to the solution a hydrocarbon solvent as a poor solvent.
L'invention porte sur un procédé de fabrication de cristaux de forme A de l'acide 2-(3-cyano-4-isobutyloxyphényl)-4-méthyl-5-thiazole carboxylique. Le procédé comprend l'étape de chauffage et de dissolution de l'acide 2-(3-cyano-4-isobutyloxyphényl)-4-méthyl5-thiazole carboxylique dans un ou plusieurs solvants, en tant que bons solvants, choisis dans le groupe constitué par le 1-propanol, le 2-propanol, l'éthanol et l'acétone, l'étape de refroidissement de la solution, et l'étape d'addition dans un solvant hydrocarboné en tant que solvant médiocre à la solution refroidie.</abstract><oa>free_for_read</oa></addata></record> |
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subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
title | PROCESS FOR PRODUCING CRYSTALS OF POLYMORPHIC 2-(3-CYANO-4-ISOBUTYLOXYPHENYL)-4-METHYL-5-THIAZOLECARBOXYLIC ACID BY POOR-SOLVENT ADDITION METHOD |
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