PROCESS FOR PRODUCING CRYSTALS OF POLYMORPHIC 2-(3-CYANO-4-ISOBUTYLOXYPHENYL)-4-METHYL-5-THIAZOLECARBOXYLIC ACID BY POOR-SOLVENT ADDITION METHOD

Disclosed is a process for producing A-form crystals of 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid, comprising: a step of dissolving by heating 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid in one or a plurality of solvents as a good solvent, selected fro...

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Hauptverfasser: TAKEYASU, TAKUMI, UEMURA, AKIHITO, NOGATA, TOMOAKI
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UEMURA, AKIHITO
NOGATA, TOMOAKI
description Disclosed is a process for producing A-form crystals of 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid, comprising: a step of dissolving by heating 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid in one or a plurality of solvents as a good solvent, selected from the group consisting of 1-propanol, 2-propanol, ethanol, and acetone; a step of cooling the solution; and a step of adding to the solution a hydrocarbon solvent as a poor solvent. L'invention porte sur un procédé de fabrication de cristaux de forme A de l'acide 2-(3-cyano-4-isobutyloxyphényl)-4-méthyl-5-thiazole carboxylique. Le procédé comprend l'étape de chauffage et de dissolution de l'acide 2-(3-cyano-4-isobutyloxyphényl)-4-méthyl­5-thiazole carboxylique dans un ou plusieurs solvants, en tant que bons solvants, choisis dans le groupe constitué par le 1-propanol, le 2-propanol, l'éthanol et l'acétone, l'étape de refroidissement de la solution, et l'étape d'addition dans un solvant hydrocarboné en tant que solvant médiocre à la solution refroidie.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title PROCESS FOR PRODUCING CRYSTALS OF POLYMORPHIC 2-(3-CYANO-4-ISOBUTYLOXYPHENYL)-4-METHYL-5-THIAZOLECARBOXYLIC ACID BY POOR-SOLVENT ADDITION METHOD
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