PRODRUG FORMS OF KINASE INHIBITORS AND THEIR USE IN THERAPY

The invention provides novel prodrug compounds comprising a kinase inhibitor and a reductively-activated fragmenting aromatic nitroheterocycle or aromatic nitrocarbocycle trigger, where the compound carries a positive charge. In preferred embodiments, the compounds are of Formula I: where: X is any...

Ausführliche Beschreibung

Bibliographische Detailangaben

Hauptverfasser:	LEE, HO HUAT, DENNY, WILLIAM ALEXANDER, ASHOORZADEH, AMIR, HAY, MICHAEL PATRICK, LU, GUO-LIANG, PATTERSON, ADAM VORN, WILSON, WILLIAM ROBERT, ANDERSON, ROBERT FORBES, SMAILL, JEFFREY BRUCE
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!